Monolithic macroporous hydrogels prepared from oil-in-water high internal phase emulsions for high-efficiency purification of Enterovirus 71

2020 ◽  
Vol 401 ◽  
pp. 126051 ◽  
Author(s):  
Huimin Gu ◽  
Yibin Liu ◽  
Lichun Wang ◽  
Baoliang Zhang ◽  
Dezhong Yin ◽  
...  
Keyword(s):  
High Efficiency ◽  
Enterovirus 71 ◽  
Internal Phase ◽  
Oil In Water

Nanoemulsions Loaded with Amphotericin B: Development, Characterization and Leishmanicidal Activity

2019 ◽  
Vol 25 (14) ◽  
pp. 1616-1622 ◽  
Author(s):  
Gabriela Muniz Félix Araújo ◽  
Gabriela Muniz Félix Araújo ◽  
Alana Rafaela Albuquerque Barros ◽  
Alana Rafaela Albuquerque Barros ◽  
João Augusto Oshiro-Junior ◽  
...  
Keyword(s):  
Amphotericin B ◽  
Average Diameter ◽  
Isopropyl Myristate ◽  
Neglected Diseases ◽  
Clinical Form ◽  
Hydrophobic Compounds ◽  
Internal Phase ◽  
Oil In Water ◽  
Spherical Structures ◽  
Lipid Formulations

Leishmaniasis is one of the most neglected diseases in the world. Its most severe clinical form, called visceral, if left untreated, can be fatal. Conventional therapy is based on the use of pentavalent antimonials and includes amphotericin B (AmB) as a second-choice drug. The micellar formulation of AmB, although effective, is associated with acute and chronic toxicity. Commercially-available lipid formulations emerged to overcome such drawbacks, but their high cost limits their widespread use. Drug delivery systems such as nanoemulsions (NE) have proven ability to solubilize hydrophobic compounds, improve absorption and bioavailability, increase efficacy and reduce toxicity of encapsulated drugs. NE become even more attractive because they are inexpensive and easy to prepare. The aim of this work was to incorporate AmB in NE prepared by sonicating a mixture of surfactants, Kolliphor® HS15 (KHS15) and Brij® 52, and an oil, isopropyl myristate. NE exhibited neutral pH, conductivity values consistent with oil in water systems, spherical structures with negative Zeta potential value, monomodal size distribution and average diameter of drug-containing droplets ranging from 33 to 132 nm. AmB did not modify the thermal behavior of the system, likely due to its dispersion in the internal phase. Statistically similar antileishmanial activity of AmB-loaded NE to that of AmB micellar formulation suggests further exploring them in terms of toxicity and effectiveness against amastigotes, with the aim of offering an alternative to treat visceral leishmaniasis.

scholarly journals High Internal Phase Oil-in-Water Pickering Emulsions Stabilized by Chitin Nanofibrils: 3D Structuring and Solid Foam 

2020 ◽  
Vol 12 (9) ◽  
pp. 11240-11251 ◽  
Author(s):  
Ya Zhu ◽  
Siqi Huan ◽  
Long Bai ◽  
Annika Ketola ◽  
Xuetong Shi ◽  
...  
Keyword(s):  
Pickering Emulsions ◽  
Internal Phase ◽  
Oil In Water

Turbulent Mixing of Two Immiscible Fluids

2005 ◽  
Vol 127 (6) ◽  
pp. 1132-1139 ◽  
Author(s):  
Thierry Lemenand ◽  
Pascal Dupont ◽  
Dominique Della Valle ◽  
Hassan Peerhossaini
Keyword(s):  
Large Scale ◽  
High Efficiency ◽  
Size Distribution Function ◽  
Immiscible Fluids ◽  
Turbulent Dissipation ◽  
Large Scale Structures ◽  
Oil In Water ◽  
New Type ◽  
Turbulence Analysis ◽  
Favorable Conditions

The emulsification process in a static mixer HEV (high-efficiency vortex) in turbulent flow is investigated. This new type of mixer generates coherent large-scale structures, enhancing momentum transfer in the bulk flow and hence providing favorable conditions for phase dispersion. We present a study of the single-phase flow that details the flow structure, based on LDV measurements, giving access on the scales of turbulence. In addition, we discuss the liquid-liquid dispersion of oil in water obtained at the exit of the mixer/emulsifier. The generation of the dispersion is characterized by the Sauter diameter and described via a size-distribution function. We are interested in a local turbulence analysis, particularly the spatial structure of the turbulence and the turbulence spectra, which give information about the turbulent dissipation rate. Finally, we discuss the emulsifier efficiency and compare the HEV performance with existing devices.

Porous functional poly(unsaturated polyester-co-glycidyl methacrylate-co-divinylbenzene) polyHIPE beads through w/o/w multiple emulsions: preparation, characterization and application

e-Polymers ◽  
2014 ◽  
Vol 14 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Emine Hilal Mert ◽  
Hüseyin Yıldırım
Keyword(s):  
Glycidyl Methacrylate ◽  
Polyester Resin ◽  
Unsaturated Polyester ◽  
Aminosalicylic Acid ◽  
Adsorption Method ◽  
Multiple Emulsions ◽  
Adsorption Capacities ◽  
Internal Phase ◽  
Oil In Water ◽  
Post Functionalization

AbstractPoly(unsaturated polyester-co-glycidyl methacrylate-co-divinylbenzene) poly high internal phase emulsion (HIPE) beads were synthesized via water-in-oil-in-water (w/o/w) multiple emulsions. HIPEs were prepared by using a commercial unsaturated polyester resin (UPR) and a mixture of glycidyl methacrylate (GMA) and divinylbenzene (DVB) as the cross-linker. The external surfactant was found to be a strong influence on the morphology of the beads. The porosity and the pore morphology of the resulting polyHIPE beads were investigated by scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) molecular adsorption method, respectively. Post-functionalization of the beads was carried out with multifunctional amines such as 1,4-ethylenediamine (EDA), 1,6-hexamethylenediamine (HMDA) and 4-aminosalicylic acid (ASA). Elemental analysis was used to confirm the functionalization. Resulting functional beads were tested on the adsorption of Ag(I), Cu(II), and Cr(III) under non-competitive conditions and atomic absorption spectroscopy (AAS) was used to calculate the adsorption capacities. The maximum adsorption capacities of the functional beads were found to be decreasing in the order of Ag(I)>Cu(II)>Cr(III).

Competitive adsorption of three phenolic compounds to hydrophilic urea-formaldehyde macroporous foams derived from lignin-based Pickering HIPEs template

RSC Advances ◽  
2016 ◽  
Vol 6 (96) ◽  
pp. 93894-93904 ◽  
Author(s):  
Jianming Pan ◽  
Jialu Luo ◽  
Jun Cao ◽  
Jinxing Liu ◽  
Wei Huang ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Competitive Adsorption ◽  
Urea Formaldehyde ◽  
Internal Phase ◽  
Oil In Water

Hydrophilic urea-formaldehyde macroporous foams (UFMF) were simply synthesized by templating oil-in-water Pickering high internal phase emulsions (HIPEs) solely stabilized by lignin particles.

Preparation of inverse polymerized high internal phase emulsions using an amphiphilic macro-RAFT agent as sole stabilizer

2016 ◽  
Vol 7 (9) ◽  
pp. 1803-1812 ◽  
Author(s):  
Aminreza Khodabandeh ◽  
R. Dario Arrua ◽  
Christopher T. Desire ◽  
Thomas Rodemann ◽  
Stefan A. F. Bon ◽  
...  
Keyword(s):  
Continuous Phase ◽  
Dispersed Phase ◽  
Internal Phase ◽  
Oil In Water ◽  
Monomer Solution ◽  
Raft Agent

Oil-in-water (‘inverse’) High Internal Phase Emulsions (HIPEs) have been prepared using an amphiphilic macro-RAFT agent with toluene as the internal dispersed phase (∼80 vol%) and an aqueous monomer solution as the continuous phase.

Kinetics of chitosan hydrogel formation in high internal phase oil-in-water emulsions (HIPEs) using viscoelastic measurements

Soft Matter ◽  
2013 ◽  
Vol 9 (36) ◽  
pp. 8678 ◽  
Author(s):  
Jonathan Miras ◽  
Susana Vílchez ◽  
Conxita Solans ◽  
Tharwat Tadros ◽  
Jordi Esquena
Keyword(s):  
Chitosan Hydrogel ◽  
Internal Phase ◽  
Oil In Water ◽  
Hydrogel Formation ◽  
Kinetics Of

Fabrication of Ofloxacin/PLGA Microsphere for Bone Tuberculosis Therapy

2013 ◽  
Vol 647 ◽  
pp. 176-180 ◽  
Author(s):  
Gang Wu ◽  
Long Chen ◽  
Chun Ling Deng ◽  
Kun Wei
Keyword(s):  
Double Emulsion ◽  
Distribution Analysis ◽  
Mesoporous Silicon ◽  
Water Solvent ◽  
Loading Efficiency ◽  
Internal Phase ◽  
Oil In Water ◽  
Phase Group ◽  
Bone Tuberculosis ◽  
Tuberculosis Therapy

The purpose of this research was to use mesoporous silicon (mpSi) as internal phase additive to improve the hydrophilic ofloxacin loaded by the hydrophobic PLGA materials through a double emulsion (water-in-oil-in-water) solvent extraction/evaporation method. Laser distribution analysis displayed low impact of MS additive on the final particles size. When compared to particle loading efficiency of none internal phase additives, MS internal phase group showed higher loading efficiency, and it increased with MS amounts inside the microparticles. All the burst releases of MS internal phase groups were severe than none MS group and was directly related the MS amount inside the microsphere. The release rate was increasing with the MS amounts added into the internal phase.

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