V-PYRRO/NO reduced leukotriene C4 production via regulating expression and activity of leukotriene C4 synthase in hepatic ischemia/reperfusio injuried rat

2008 ◽  
Vol 32 (3) ◽  
pp. S52-S52
Author(s):  
Fen Fang Hong ◽  
Shu Long Yang
Keyword(s):  
Leukotriene C4 ◽  
Hepatic Ischemia ◽  
C4 Production ◽  
Leukotriene C4 Synthase ◽  
Expression And Activity

Leukotriene C4 Synthase: Upcoming Drug Target For Inflammation

2012 ◽  
Vol 13 (8) ◽  
pp. 1114-1125 ◽  
Author(s):  
Nisha S. Devi ◽  
Mukesh Doble
Keyword(s):  
Drug Target ◽  
Leukotriene C4 ◽  
Leukotriene C4 Synthase

scholarly journals Leukotriene C4 synthase polymorphisms and responsiveness to leukotriene antagonists in asthma

2003 ◽  
Vol 56 (4) ◽  
pp. 422-426 ◽  
Author(s):  
Graeme P. Currie ◽  
John J. Lima ◽  
Jim E. Sylvester ◽  
Daniel K. C. Lee ◽  
Wendy J. R. Cockburn ◽  
...  
Keyword(s):  
Leukotriene C4 ◽  
Leukotriene Antagonists ◽  
Leukotriene C4 Synthase

Tumour Necrosis Factor-α and Endotoxin Induce Less Prostaglandin E2 Production from Hypothalami of Rats Fed Coconut Oil than from Hypothalami of Rats Fed Maize Oil

1990 ◽  
Vol 79 (6) ◽  
pp. 657-662 ◽  
Author(s):  
David C. Bibby ◽  
Robert F. Grimble
Keyword(s):  
Prostaglandin E2 ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Coconut Oil ◽  
Leukotriene C4 ◽  
Tumour Necrosis Factor Α ◽  
Factor Α ◽  
C4 Production ◽  
Necrosis Factor ◽  
Maize Oil

1. The primary aim of the study was to determine whether the stimulatory effect of tumour necrosis factor-α and endotoxin on hypothalamic prostaglandin E2 production was influenced by dietary fats containing different amounts of linoleic acid. Rats received diets containing 20% (w/w) maize oil or 19% (w/w) coconut oil plus 1% (w/w) maize oil for 8 weeks. 2. A subsidiary part of the study examined the effect of tumour necrosis factor-α on the ability of the calcium ionophore A23187 to stimulate prostaglandin E2 and leukotriene C4 production by hypothalami from chow-fed rats. 3. While tumour necrosis factor-α enhanced prostaglandin E2 production in response to A23187, neither agent had an effect on leukotriene C4 production. 4. Hypothalami from rats fed maize oil exhibited increased prostaglandin E2 production in response to both pyrogens. This did not occur with hypothalami from rats fed coconut oil. 5. Coconut oil might exert its modulatory effect by bringing about a reduction in membrane phospholipid arachidonic acid content.

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