Potential role of adenylyl cyclase 8 signaling complexes in regulating insulin secretion from pancreatic beta cells

2020 ◽  
Vol 72 ◽  
pp. 109635
Author(s):  
Ida Lønsmann ◽  
Lasse K. Bak
Keyword(s):  
Insulin Secretion ◽  
Adenylyl Cyclase ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Potential Role ◽  
Adenylyl Cyclase 8

scholarly journals Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells

Diabetologia ◽  
2014 ◽  
Vol 58 (2) ◽  
pp. 324-333 ◽  
Author(s):  
Haiqiang Dou ◽  
Changhe Wang ◽  
Xi Wu ◽  
Lijun Yao ◽  
Xiaoyu Zhang ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Adenylyl Cyclase ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Calcium Influx ◽  
Adenylyl Cyclase 8

scholarly journals The Role of Phosphofructokinase-M (Pfkm) in Oscillatory Glycolysis and Insulin Secretion in Pancreatic Beta Cells

2019 ◽  
Vol 116 (3) ◽  
pp. 235a
Author(s):  
Vishal S. Parekh ◽  
Jim Ren ◽  
Leslie S. Satin
Keyword(s):  
Insulin Secretion ◽  
Beta Cells ◽  
Pancreatic Beta Cells

Potential Role of NO in Modulation of COX-2 Expression and PGE2 Production in Pancreatic beta-cells

2005 ◽  
Vol 37 (2) ◽  
pp. 139-146 ◽  
Author(s):  
Jia-Jian LING ◽  
Yu-Jie SUN ◽  
Dong-Ya ZHU ◽  
Qi CHEN ◽  
Xiao HAN
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Potential Role ◽  
Pge2 Production ◽  
Cox 2

scholarly journals The Potential Role of SOCS-3 in the Interleukin-1 -Induced Desensitization of Insulin Signaling in Pancreatic Beta-Cells

Diabetes ◽  
2004 ◽  
Vol 53 (Supplement 3) ◽  
pp. S97-S103 ◽  
Author(s):  
B. Emanuelli ◽  
M. Glondu ◽  
C. Filloux ◽  
P. Peraldi ◽  
E. Van Obberghen
Keyword(s):  
Beta Cells ◽  
Insulin Signaling ◽  
Pancreatic Beta Cells ◽  
Potential Role ◽  
Interleukin 1

scholarly journals The Adenylyl Cyclase Inhibitor MDL-12,330A Potentiates Insulin Secretion via Blockade of Voltage-Dependent K+ Channels in Pancreatic Beta Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77934 ◽  
Author(s):  
Xiaodong Li ◽  
Qing Guo ◽  
Jingying Gao ◽  
Jing Yang ◽  
Wan Zhang ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Adenylyl Cyclase ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
K Channels ◽  
Voltage Dependent ◽  
Adenylyl Cyclase Inhibitor

scholarly journals In vivo phosphoproteomics reveals pathogenic signaling changes in diabetic islets

2018 ◽  
Author(s):  
Francesca Sacco ◽  
Anett Seelig ◽  
Sean J. Humphrey ◽  
Natalie Krahmer ◽  
Francesco Volta ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Drug Targets ◽  
High Sensitivity ◽  
Glucose Stimulated Insulin Secretion

SUMMARYProgressive decline of pancreatic beta cells function is key to the pathogenesis of type 2 diabetes. Protein phosphorylation is the central mechanism controlling glucose-stimulated insulin secretion in beta cells. However, if and how signaling networks are remodeled in diabetic isletsin vivoremain unknowns. Here we applied high-sensitivity mass spectrometry-based proteomics and quantified the levels of about 6,500 proteins and 13,000 phosphopeptides in islets of obese diabetic mice and matched controls. This highlighted drastic remodeling of key kinase hubs and signaling pathways. We integrated our phosphoproteomic dataset with a literature-derived signaling network, which revealed a crucial and conserved role of GSK3 kinase in the control of the beta cells-specific transcription factor PDX1 and insulin secretion, which we functionally verified. Our resource will enable the community to investigate potential mechanisms and drug targets in type 2 diabetes.

scholarly journals The role of pyruvate carboxylase in insulin secretion and proliferation in rat pancreatic beta cells

Diabetologia ◽  
2008 ◽  
Vol 51 (11) ◽  
pp. 2022-2030 ◽  
Author(s):  
J. Xu ◽  
J. Han ◽  
Y. S. Long ◽  
P. N. Epstein ◽  
Y. Q. Liu
Keyword(s):  
Insulin Secretion ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Pyruvate Carboxylase
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