scholarly journals PDF Signaling Is an Integral Part of the Drosophila Circadian Molecular Oscillator

Cell Reports ◽  
2016 ◽  
Vol 17 (3) ◽  
pp. 708-719 ◽  
Author(s):  
Shaul Mezan ◽  
Jean Daniel Feuz ◽  
Bart Deplancke ◽  
Sebastian Kadener
Keyword(s):  
Molecular Oscillator

The Tgf--/Bmp Co-Receptor Endoglin Is a Key Component of the Molecular Oscillator That Regulates the Hair Follicle Cycle

2018 ◽  
Author(s):  
Marra I. Calvo-SSnchez ◽  
Elisa Carrasco ◽  
Sandra Fernnndez-Martos ◽  
Gema Moreno ◽  
Carmelo Bernabeu ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Molecular Oscillator ◽  
Hair Follicle Cycle

Ramsey type radiation line in a molecular oscillator with spaced cavities

1968 ◽  
Vol 9 (3) ◽  
pp. 374-375 ◽  
Author(s):  
V. S. Kazachok
Keyword(s):  
Radiation Line ◽  
Molecular Oscillator ◽  
Ramsey Type

The effect of small cluster environment on molecular oscillator strengths and spectra

1988 ◽  
Vol 88 (6) ◽  
pp. 3516-3523 ◽  
Author(s):  
Naomi Liver ◽  
Abraham Nitzan ◽  
Aviv Amirav ◽  
Joshua Jortner
Keyword(s):  
Small Cluster ◽  
Oscillator Strengths ◽  
Molecular Oscillator ◽  
Cluster Environment

Adiabatic Potentials and Oscillator Strengths of Thallium-Noble Gas Atom Pairs

1982 ◽  
Vol 37 (4) ◽  
pp. 325-333
Author(s):  
E. Czuchaj
Keyword(s):  
Noble Gas ◽  
Semiempirical Method ◽  
Oscillator Strengths ◽  
Continuum Emission ◽  
Interatomic Potentials ◽  
Internuclear Separation ◽  
Molecular Oscillator ◽  
Asymptotic Values ◽  
Atom Pairs

Abstract Baylis' semiempirical method has been applied for calculating interatomic potentials and oscillator strengths as a function of internuclear separation of the thallium-noble gas systems. The new potentials for the four lowest molecular states of each diatomic have been compared with the corresponding ones deduced by Cheron et al. from the measurement of continuum emission intensities on the extreme wings of the Tl resonance lines due to noble gas perturbers. The calculated potentials differ considerably from the latter ones. The molecular oscillator strengths have been calculated for both the allowed and the forbidden Tl transitions. The asymptotic values of the first ones are compared with the corresponding atomic oscillator strengths of other calculations and measurements. The agreement is generally quite good.

Investigation of a molecular oscillator with two series resonators on two opposing beams

1966 ◽  
Vol 8 (4) ◽  
pp. 590-592 ◽  
Author(s):  
A. F. Mukhamedgalieva ◽  
G. M. Strakhovskii
Keyword(s):  
Molecular Oscillator

Circadian variations of adenosine and of its metabolism. Could adenosine be a molecular oscillator for circadian rhythms?

1995 ◽  
Vol 73 (3) ◽  
pp. 339-355 ◽  
Author(s):  
Victoria Chagoya de Sánchez
Keyword(s):  
Membrane Structure ◽  
Adenosine Kinase ◽  
Light Cycle ◽  
Circadian Variations ◽  
Dark Light ◽  
Metabolic Pattern ◽  
Molecular Oscillator ◽  
Adenosine Concentration ◽  
Membrane Structure And Function ◽  
Different Tissues

The present review describes the biological implications of the periodic changes of adenosine concentrations in different tissues of the rat. Adenosine is a purine molecule that could have been formed in the prebiotic chemical evolution and has been preserved. The rhythmicity of this molecule, as well as its metabolism and even the presence of specific receptors, suggests a regulatory role in eukaryotic cells and in multicellular organisms. Adenosine may be considered a chemical messenger and its action could take place at the level of the same cell (autocrine), the same tissue (paracrine), or on separate organs (endocrine). Exploration of the circadian variations of adenosine was planned considering the liver as an important tissue for purine formation, the blood as a vehicle among tissues, and the brain as the possible acceptor for hepatic adenosine or its metabolites. The rats used in these studies were adapted to a dark–light cycle of 12 h with an unrestrained feeding and drinking schedule. The metabolic control of adenosine concentration in the different tissues studied through the 24-h cycle is related to the activity of adenosine-metabolizing enzymes: 5′-nucleotidase adenosine deaminase, adenosine kinase, and S-adenosylhomocysteine hydrolase. Some possibilities of the factors modulating the activity of these enzymes are commented upon. The multiphysiological action of adenosine could be mediated by several actions: (i) by interaction with extracellular and intracellular receptors and (ii) through its metabolism modulating the methylation pathway, possibly inducing physiological lipoperoxidation, or participating in the energetic homeostasis of the cell. The physiological meaning of the circadian variations of adenosine and its metabolism was focused on: maintenance of the energetic homeostasis of the tissues, modulation of membrane structure and function, regulation of fasting and feeding metabolic pattern, and its participation in the sleep–wake cycle. From these considerations, we suggest that adenosine could be a molecular oscillator involved in the circadian pattern of biological activity in the rat.Key words: adenosine, circadian rhythm energy, membrane structure, sleep–wake cycle.

scholarly journals Ribosomal S6 Kinase Cooperates with Casein Kinase 2 to Modulate the Drosophila Circadian Molecular Oscillator

2009 ◽  
Vol 29 (2) ◽  
pp. 466-475 ◽  
Author(s):  
B. Akten ◽  
M. M. Tangredi ◽  
E. Jauch ◽  
M. A. Roberts ◽  
F. Ng ◽  
...  
Keyword(s):  
Casein Kinase ◽  
Casein Kinase 2 ◽  
S6 Kinase ◽  
Molecular Oscillator ◽  
Ribosomal S6 Kinase

scholarly journals Communicating clocks shape circadian homeostasis

Science ◽  
2021 ◽  
Vol 371 (6530) ◽  
pp. eabd0951 ◽  
Author(s):  
Kevin B. Koronowski ◽  
Paolo Sassone-Corsi
Keyword(s):  
Metabolic Syndrome ◽  
Human Health ◽  
Modern Society ◽  
Life Forms ◽  
Circadian Clocks ◽  
Biological Clocks ◽  
Circadian Misalignment ◽  
Molecular Oscillator ◽  
Wide System ◽  
Challenges And Opportunities

Circadian clocks temporally coordinate physiology and align it with geophysical time, which enables diverse life-forms to anticipate daily environmental cycles. In complex organisms, clock function originates from the molecular oscillator within each cell and builds upward anatomically into an organism-wide system. Recent advances have transformed our understanding of how clocks are connected to achieve coherence across tissues. Circadian misalignment, often imposed in modern society, disrupts coordination among clocks and has been linked to diseases ranging from metabolic syndrome to cancer. Thus, uncovering the physiological circuits whereby biological clocks achieve coherence will inform on both challenges and opportunities in human health.

scholarly journals Fgf/MAPK signalling is a crucial positional cue in somite boundary formation

Development ◽  
2001 ◽  
Vol 128 (23) ◽  
pp. 4873-4880 ◽  
Author(s):  
Atsushi Sawada ◽  
Minori Shinya ◽  
Yun-Jin Jiang ◽  
Atsushi Kawakami ◽  
Atsushi Kuroiwa ◽  
...  
Keyword(s):  
Experimental Manipulation ◽  
Notch Signalling ◽  
Presomitic Mesoderm ◽  
Mapk Activation ◽  
Boundary Formation ◽  
Molecular Oscillator ◽  
Spatial Regulation ◽  
Mapk Signalling ◽  
Temporal And Spatial ◽  
Segmentation Point

The temporal and spatial regulation of somitogenesis requires a molecular oscillator, the segmentation clock. Through Notch signalling, the oscillation in cells is coordinated and translated into a cyclic wave of expression of hairy-related and other genes. The wave sweeps caudorostrally through the presomitic mesoderm (PSM) and finally arrests at the future segmentation point in the anterior PSM. By experimental manipulation and analyses in zebrafish somitogenesis mutants, we have found a novel component involved in this process. We report that the level of Fgf/MAPK activation (highest in the posterior PSM) serves as a positional cue within the PSM that regulates progression of the cyclic wave and thereby governs the positions of somite boundary formation.

The theory of a molecular oscillator and a molecular power amplifier

1955 ◽  
Vol 19 ◽  
pp. 96 ◽  
Author(s):  
N. G. Bassov ◽  
A. M. Prokhorov
Keyword(s):  
Power Amplifier ◽  
Molecular Oscillator
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