An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

Intranasal vaccine is a novel candidate that could improve the current injectable vaccine for the to prevent seasonal influenza epidemics. Influenza intranasal spray vaccine causes a local antibody response.

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Human parainfluenza virus type 3 expressing the respiratory syncytial virus pre-fusion F protein modified for virion packaging yields protective intranasal vaccine candidates

PLoS ONE ◽

10.1371/journal.pone.0228572 ◽

2020 ◽

Vol 15 (2) ◽

pp. e0228572 ◽

Cited By ~ 4

Author(s):

Xueqiao Liu ◽

Bo Liang ◽

Xiang Liu ◽

Emerito Amaro-Carambot ◽

Sonja Surman ◽

...

Keyword(s):

Respiratory Syncytial Virus ◽

Virus Type ◽

Parainfluenza Virus ◽

Vaccine Candidates ◽

F Protein ◽

Intranasal Vaccine ◽

Syncytial Virus ◽

Human Parainfluenza Virus ◽

Type 3

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Synthetic Polyacrylate Polymers as Particulate Intranasal Vaccine Delivery Systems for the Induction of Mucosal Immune Response

Current Drug Delivery ◽

10.2174/156720110791011846 ◽

2010 ◽

Vol 7 (2) ◽

pp. 118-124 ◽

Cited By ~ 12

Author(s):

Mehfuz Zaman ◽

Pavla Simerska ◽

Istvan Toth

Keyword(s):

Immune Response ◽

Vaccine Delivery ◽

Mucosal Immune Response ◽

Delivery Systems ◽

Intranasal Vaccine

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Formulation, High Throughput In Vitro Screening and In Vivo Functional Characterization of Nanoemulsion-Based Intranasal Vaccine Adjuvants

PLoS ONE ◽

10.1371/journal.pone.0126120 ◽

2015 ◽

Vol 10 (5) ◽

pp. e0126120 ◽

Cited By ~ 17

Author(s):

Pamela T. Wong ◽

Pascale R. Leroueil ◽

Douglas M. Smith ◽

Susan Ciotti ◽

Anna U. Bielinska ◽

...

Keyword(s):

High Throughput ◽

Functional Characterization ◽

In Vitro Screening ◽

Vaccine Adjuvants ◽

Intranasal Vaccine

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Intranasal Vaccine Using P10 Peptide Complexed within Chitosan Polymeric Nanoparticles as Experimental Therapy for Paracoccidioidomycosis in Murine Model

Journal of Fungi ◽

10.3390/jof6030160 ◽

2020 ◽

Vol 6 (3) ◽

pp. 160

Author(s):

Samuel Rodrigues Dos Santos Junior ◽

Francenya Kelley Lopes da Silva ◽

Lucas Santos Dias ◽

Ana Camila Oliveira Souza ◽

Marcelo Valdemir de Araujo ◽

...

Keyword(s):

Polymeric Nanoparticles ◽

Paracoccidioides Brasiliensis ◽

Physicochemical Characteristics ◽

Fungal Species ◽

Experimental Therapy ◽

Medium Size ◽

Biological Applications ◽

Dispersion Index ◽

Fungal Load ◽

Intranasal Vaccine

Paracoccidioidomycosis (PCM) is a granulomatous fungal disease caused by the dimorphic fungal species of Paracoccidioides, which mainly affects the lungs. Modern strategies for the treatment and/or prevention of PCM are based on a Th1-type immune response, which is important for controlling the disease. One of the most studied candidates for a vaccine is the P10 peptide, derived from the 43 kDa glycoprotein of Paracoccidioides brasiliensis. In order to improve its immune modulatory effect, the P10 peptide was associated with a chitosan-conjugated nanoparticle. The nanoparticles presented 220 nm medium size, poly dispersion index (PDI) below 0.5, zeta potential of +20 mV and encapsulation efficiency around 90%. The nanoparticles’ non-toxicity was verified by hemolytic test and cell viability using murine macrophages. The nanoparticles were stable and presented physicochemical characteristics desirable for biological applications, reducing the fungal load and the usual standard concentration of the peptide from 4 to 20 times.

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