Influences of gallium substitution on the phase stability, mechanical strength and cellular response of β-tricalcium phosphate bioceramics

This study reports the enhanced mechanical resistance of the composite bioceramics of hydroxyapatite (HAP) and tricalcium phosphate (β-TCP) used as bone substitute. HAP/β-TCP mixture was prepared by wet mixing of powders and characterized. Effects of powder manufacturing and sintering temperature on the densification, microstructure and mechanical properties of the composite were studied. The rupture strength (σr) was calculated using the Brazilian test. At 1250 °C, the relative density and mechanical strength of the HAP/β-TCP ceramics reached the maximum value of 89% and 43 MPa, respectively. Experimental results were modeled by the finite element method to determine the stress distribution in the compacted disc.

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Effect of Mixed Addition of Al2O3 and SiO2 on Mechanical Strength of Sintered β-Tricalcium Phosphate

Journal of the Ceramic Society of Japan ◽

10.2109/jcersj.96.837 ◽

1988 ◽

Vol 96 (1116) ◽

pp. 837-841 ◽

Cited By ~ 9

Author(s):

Motohiro TORIYAMA ◽

Sukezo KAWAMURA ◽

Yukari ITO ◽

Hajime NAGAE ◽

Ikuo TOYAMA

Keyword(s):

Mechanical Strength ◽

Tricalcium Phosphate

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Conjunction of gallium doping and calcium silicate mediates osteoblastic and osteoclastic performances of tricalcium phosphate bioceramics

Biomedical Materials ◽

10.1088/1748-605x/ac3d9a ◽

2021 ◽

Author(s):

Fupo He ◽

Chao Qiu ◽

Teliang Lu ◽

Xuetao Shi ◽

Jiandong Ye

Keyword(s):

Mechanical Strength ◽

Tricalcium Phosphate ◽

Calcium Silicate ◽

Bone Defects ◽

Osteoporotic Bone ◽

Densification Process ◽

Potent Effect ◽

Inhibition Effect ◽

Gallium Doping

Abstract Gallium-containing biomaterials are considered promising for reconstructing osteoporotic bone defects, owing to the potent effect of gallium on restraining osteoclast activities. Nevertheless, the gallium-containing biomaterials were demonstrated to disturb the osteoblast activities. In this study, tricalcium phosphate (TCP) bioceramics were modified by gallium doping in conjunction with incorporation of calcium silicate (CS). The results indicated that the incorporation of CS promoted transition of β-TCP to α-TCP, and accelerated densification process, but did not improve the mechanical strength of bioceramics. The silicon released from the composite bioceramics diminished the inhibition effect of released gallium on osteoblast activities, and maintained its effect on restraining osteoclast activities. The TCP-based bioceramics doped with 2.5 mol% gallium and incorporated with 10 mol% CS are considered suitable for treating the bone defects in the osteoporotic environment.

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In vitro change in mechanical strength of ?-tricalcium phosphate/copolymerized poly-L-lactide composites and their application for guided bone regeneration

Journal of Biomedical Materials Research ◽

10.1002/jbm.10248 ◽

2002 ◽

Vol 62 (2) ◽

pp. 265-272 ◽

Cited By ~ 82

Author(s):

Masanori Kikuchi ◽

Yoshihisa Koyama ◽

Kazuo Takakuda ◽

Hiroo Miyairi ◽

Noriaki Shirahama ◽

...

Keyword(s):

Mechanical Strength ◽

Bone Regeneration ◽

Tricalcium Phosphate ◽

Guided Bone Regeneration

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The Influence of Three Additives on the Setting Reaction Kinetics and Mechanical Strength Evolution of [Alpha]-Tricalcium Phosphate Cements

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.493-494.397 ◽

2011 ◽

Vol 493-494 ◽

pp. 397-402

Author(s):

H.A.I. Cardoso ◽

M. Motisuke ◽

Cecília A.C. Zavaglia

Keyword(s):

Calcium Phosphate ◽

Mechanical Strength ◽

Reaction Kinetics ◽

Tricalcium Phosphate ◽

Hydrogen Phosphate ◽

Disodium Hydrogen Phosphate ◽

Setting Reaction ◽

Calcium Phosphate Cements ◽

Strength Evolution ◽

Low Load

Among the calcium phosphate cements, the system based on alpha-tricalcium phosphate (α-TCP) combines several interesting properties. However, these cements have their use limited to low load applications. The main objective of this study is to evaluate the influence of three different additives on the setting reaction kinetics and mechanical strength evolution of calcium phosphate cements as a function of time. The cement was obtained by mixing α-TCP powder with four different aqueous solutions containing or not containing disodium hydrogen phosphate (Na2HPO4), citric acid (C6H8O7) and/or tannic acid (C76H52O46). It was observed that two cement samples, one of them containing Na2HPO4 and C6H8O7 and another containingNa2HPO4 and C76H52O46 in the liquid phase, presented faster setting reaction and higher mechanical properties. These cements are more suitable for application as bone cement.

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Effect of Added Tricalcium Phosphate on Basic Properties of Apatite Cement

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.361-363.339 ◽

2007 ◽

Vol 361-363 ◽

pp. 339-342

Author(s):

Akari Takeuchi ◽

Akinari Nakagawa ◽

Shigeki Matsuya ◽

Ishikawa Kunio

Keyword(s):

Crystal Growth ◽

Mechanical Strength ◽

Tricalcium Phosphate ◽

Setting Time ◽

Tetracalcium Phosphate ◽

Initial Setting Time ◽

Setting Reaction ◽

Phosphate Ions ◽

Initial Setting ◽

Apatite Cement

Effect of added α-tricalcium phosphate (α-TCP) and β-TCP was investigated to understand the setting reaction of apatite cement consisting of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA). Addition of TCP delayed the initial setting time because TCP was not involved in the initial setting reaction and resulted in the decreased initial mechanical strength. After the initial setting of the cement due to the conversion of TTCP and DCPA into apatite, α-TCP dissolved to supply calcium and phosphate ions and they were consumed for crystal growth of apatite. Therefore, mechanical strength of the apatite cement containing α-TCP was increased. In contrast, added β-TCP showed no reactivity in the cement and thus result in the decreased mechanical strength.

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