Self-heating evaluation of superparamagnetic MnFe2O4 nanoparticles for magnetic fluid hyperthermia application towards cancer treatment

Iron oxide nanoparticle-based hyperthermia is an emerging field in cancer treatment. The hyperthermia is primarily achieved by two differing methods: magnetic fluid hyperthermia and photothermal therapy. In magnetic fluid hyperthermia, the iron oxide nanoparticles are heated by an alternating magnetic field through Brownian and Néel relaxation. In photothermal therapy, the hyperthermia is mainly generated by absorption of light, thereby converting electromagnetic waves into thermal energy. By use of iron oxide nanoparticles, this effect can be enhanced. Both methods are promising tools in cancer treatment and are, therefore, also explored for gastrointestinal malignancies. Here, we provide an extensive literature research on both therapy options for the most common gastrointestinal malignancies (esophageal, gastric and colorectal cancer, colorectal liver metastases, hepatocellular carcinoma, cholangiocellular carcinoma and pancreatic cancer). As many of these rank in the top ten of cancer-related deaths, novel treatment strategies are urgently needed. This review describes the efforts undertaken in vitro and in vivo.

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Study on Cancer Treatment using Magnetic Fluid for Medicine and Induction Heating Device

IEEJ Transactions on Fundamentals and Materials ◽

10.1541/ieejfms.133.366 ◽

2013 ◽

Vol 133 (6) ◽

pp. 366-371 ◽

Cited By ~ 4

Author(s):

Hideo Nagae ◽

Sotoshi Yamada ◽

Yoshio Ikehata ◽

Satoshi Yagitani ◽

Isamu Nagano

Keyword(s):

Cancer Treatment ◽

Induction Heating ◽

Magnetic Fluid ◽

Heating Device

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Structural, Morphological, Magnetic and Self-Heating Studies of One-Step Polyol Synthesized Manganese Ferrite (MnFe2O4) Nanoparticles

International Journal of Nanoscience ◽

10.1142/s0219581x19500030 ◽

2019 ◽

Vol 19 (01) ◽

pp. 1950003

Author(s):

P. R. Ghutepatil ◽

S. H. Pawar

Keyword(s):

Room Temperature ◽

Synthesis Method ◽

Average Crystallite Size ◽

Superparamagnetic Nanoparticles ◽

Polyol Synthesis ◽

X Ray Diffraction ◽

Self Heating ◽

Transmission Electron ◽

One Step ◽

Mnfe2o4 Nanoparticles

In this paper, uniform and superparamagnetic nanoparticles have been prepared using one-step polyol synthesis method. Structural, morphological and magnetic properties of obtained MnFe2O4 nanoparticles have been investigated by using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscope (FE-SEM), transmission electron microscopy (TEM), vibrating sample magnetometry (VSM) and thermogravimetric analysis (TGA) techniques. Structural investigation showed that the average crystallite size of obtained nanoparticles was about 10[Formula: see text]nm. Magnetic study revealed that the nanoparticles were superparamagnetic at room temperature with magnetization 67[Formula: see text]emu/g at room temperature. The self-heating characteristics of synthesized MnFe2O4 nanoparticles were studied by applying external AC magnetic field of 167.6 to 335.2[Formula: see text]Oe at a fixed frequency of 265[Formula: see text]kHz. The SAR values of MnFe2O4 nanoparticles were calculated for 2, 5, 10[Formula: see text]mg[Formula: see text]mL[Formula: see text] concentrations and it is observed that the threshold hyperthermia temperature is achieved for all concentrations.

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