Magnetic fluid hyperthermia (MFH): Cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles

1999 ◽  
Vol 201 (1-3) ◽  
pp. 413-419 ◽  
Author(s):  
Andreas Jordan ◽  
Regina Scholz ◽  
Peter Wust ◽  
Horst Fähling ◽  
Roland Felix
Keyword(s):  
Magnetic Field ◽  
Cancer Treatment ◽  
Magnetic Fluid ◽  
Superparamagnetic Nanoparticles ◽  
Magnetic Fluid Hyperthermia ◽  
Ac Magnetic Field

On the in Vitro Hyperthermia of Magnetic Fluid in AC Magnetic Field

2009 ◽  
Author(s):  
Junfeng Jiang ◽  
Ruoyu Hong ◽  
Xiaohui Zhang ◽  
Hongzhong Li
Keyword(s):  
Magnetic Field ◽  
Magnetic Fluid ◽  
Volume Fraction ◽  
Maximum Temperature ◽  
Magnetic Fluid Hyperthermia ◽  
Ac Magnetic Field ◽  
Hyperthermia Therapy ◽  
Good Biocompatibility ◽  
High Chemical Stability

Hyperthermia therapy for cancer has attracted much attention nowadays. The study on the heat transfer in the magnetic fluid and the tumor is crucial for the successful application of magnetic fluid hyperthermia (MFH). Water-based Fe3O4 magnetic fluid is expected to be a most appropriate candidate for MFH due to the good biocompatibility, high saturation magnetization, super-paramagnetization and high chemical stability. In this paper, we explore the heat generation and transfer in magnetic fluid which is placed under an AC magnetic field. It is found that the amplitude and the frequency of alternating magnetic field, particle size and volume fraction have a pronounce influence on maximum temperature of hyperthermia.

scholarly journals Enhanced Cancer Cell (HeLa) Killing Efficacy of Mixed Αlpha and Gamma Iron Oxide Superparamagnetic Nanoparticles under Combined AC (Alternating Current) Magnetic-Field and Photoexcitation

1970 ◽  
Vol 12 (4) ◽  
Author(s):  
Md. Shariful Islam, Yoshihumi Kusumoto, Md. Abdulla Al-Mamun And Yuji Horie
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Hela Cells ◽  
Room Temperature ◽  
Heat Dissipation ◽  
Alternating Current ◽  
Superparamagnetic Nanoparticles ◽  
Gamma Iron ◽  
Ac Magnetic Field ◽  
Current Magnetic Field

We synthesized mixed α and γ-Fe2O3 nanoparticles and investigated their toxic effects against HeLa cells under induced AC (alternating current) magnetic-fields and photoexcited conditions at room temperature. The findings revealed that the cell-killing percentage was increased with increasing dose for all types of treatments. Finally, 99% cancer cells were destructed at 1.2 mL dose when exposed to combined AC magnetic-field and photoexcited conditions (T3) whereas 89 and 83 % of HeLa cells were killed under only AC magnetic-field induced (T1) or only photoexcited (T2) condition at the same dose.ABSTRAK: Campuran α dan zarah γ-Fe2O3 bersaiz nano disintesiskan dan kesan toksidnya terhadap sel HeLa dikaji dibawah aruhan medan magnet arus ulang-alik (alternating current (AC)) dan keadaan photoexcited (proses ransangan atom atau molekul suatu bahan dengan penyerapan tenaga sinaran) pada suhu bilik. Penemuan mendedahkan bahawa peratusan sel yang musnah bertambah dengan pertambahan dos untuk semua jenis rawatan. Akhirnya, 99% sel kanser dimusnahkan pada kadar dos 1.2mL setelah didedahkan terhadap kombinasi medan magnet AC dan keadaan photoexcited (T3) dimana 89% dan 83% sel HeLa dimusnahkan dengan hanya di bawah aruhan medan magnet AC (T1) atau hanya pada keadaan photoexcited (T2) pada kadar dos yang sama.KEY WORDS : Cancer, Hyperthermia, Iron oxide nanoparticles, Heat dissipation,    Cytotoxicity, HeLa cell.

scholarly journals Induction Heating Analysis of Surface-Functionalized Nanoscale CoFe2O4 for Magnetic Fluid Hyperthermia toward Noninvasive Cancer Treatment

ACS Omega ◽  
2020 ◽  
Vol 5 (36) ◽  
pp. 23378-23384 ◽  
Author(s):  
Prashant B. Kharat ◽  
Sandeep B. Somvanshi ◽  
Pankaj P. Khirade ◽  
K. M. Jadhav
Keyword(s):  
Cancer Treatment ◽  
Induction Heating ◽  
Magnetic Fluid ◽  
Magnetic Fluid Hyperthermia

MAGNETIC FLUID HYPERTHERMIA IN A CYLINDRICAL GEL CONTAINS WATER FLOW

2015 ◽  
Vol 15 (05) ◽  
pp. 1550088 ◽  
Author(s):  
MORTEZA HEYDARI ◽  
MEHRDAD JAVIDI ◽  
MOHAMMAD MAHDI ATTAR ◽  
ALIREZA KARIMI ◽  
MAHDI NAVIDBAKHSH ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Experimental Data ◽  
Fluid Flow ◽  
Magnetic Fluid ◽  
Blood Perfusion ◽  
Temperature Function ◽  
Magnetic Fluid Hyperthermia ◽  
Frequency Magnetic Field ◽  
Complicated Part ◽  
Cancerous Cells

In magnetic fluid hyperthermia (MFH), nanoparticles are injected into a diseased tissue and then subjected to an alternating high frequency magnetic field. The produced heat may have a key asset to destroy the cancerous cells. The blood flow in a tissue is considered as the most complicated part of the MFH which should be taken into account in the analysis of the MFH. This study was aimed to perform an experimental study to investigate the heat transfer of agar gel which contains fluid flow. Fe 3 O 4 as a nanoparticle was injected into the center of a cylindrical gel. It was also embedded with other cylindrical gels and subjected to an alternating magnetic field of 7.3 (kA/m) and a frequency of 50 (kHz) for 3600 (s). The temperature of the gel was measured at three points. The temperature distribution was measured via the experimental data. Moreover, specific absorption rate (SAR) was quantified with time differential temperature function at t = 0 by means of experimental data. Finite element method (FEM) was employed to establish a model to validate the SAR function. Results revealed the effects of fluid flow and accuracy of the SAR function for heat production in gel. The proposed function have implications in hyperthermia studies as a heat generation source. Finally, the condition of experimental setup was simulated to find the blood perfusion.

scholarly journals Frequency dependence of magnetothermal properties for magnetic fluid and magnetically functionalized implants

2018 ◽  
Vol 185 ◽  
pp. 09003
Author(s):  
R.T. Salakhova ◽  
A. G. Vylegzhanin ◽  
E.A. Kashtanov ◽  
V.I. Zverev ◽  
R. Müller ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Frequency Dependence ◽  
Magnetic Fluid ◽  
Magnetite Nanoparticles ◽  
Polymer Coating ◽  
Experimental Setup ◽  
Ac Magnetic Field ◽  
Magnetic Heating ◽  
Magnetite Particles

Heating of the magnetic nanoparticles in AC magnetic field is the effect promising for application in medicine. The mechanisms of heating in AC-magnetic field implies nontrivial dependence of the power dissipated by magnetic nanoparticles on frequency. With the use of a reconfigurable experimental setup, this frequency-dependent magnetic heating was measured on two characteristic examples: the magnetite nanoparticles conventionally used in medicine and polymer coating with micrometer sized magnetite particles. The saturation of the heating power with frequency is shown that is more pronounced for the second case of microparticles.

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