scholarly journals Iron Oxide Nanoparticle-Based Hyperthermia as a Treatment Option in Various Gastrointestinal Malignancies

Nanomaterials ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 3013
Author(s):  
Julian Palzer ◽  
Lea Eckstein ◽  
Ioana Slabu ◽  
Oliver Reisen ◽  
Ulf P. Neumann ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cancer Treatment ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Fluid ◽  
Photothermal Therapy ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
Gastrointestinal Malignancies ◽  
Magnetic Fluid Hyperthermia ◽  
Oxide Nanoparticle

Iron oxide nanoparticle-based hyperthermia is an emerging field in cancer treatment. The hyperthermia is primarily achieved by two differing methods: magnetic fluid hyperthermia and photothermal therapy. In magnetic fluid hyperthermia, the iron oxide nanoparticles are heated by an alternating magnetic field through Brownian and Néel relaxation. In photothermal therapy, the hyperthermia is mainly generated by absorption of light, thereby converting electromagnetic waves into thermal energy. By use of iron oxide nanoparticles, this effect can be enhanced. Both methods are promising tools in cancer treatment and are, therefore, also explored for gastrointestinal malignancies. Here, we provide an extensive literature research on both therapy options for the most common gastrointestinal malignancies (esophageal, gastric and colorectal cancer, colorectal liver metastases, hepatocellular carcinoma, cholangiocellular carcinoma and pancreatic cancer). As many of these rank in the top ten of cancer-related deaths, novel treatment strategies are urgently needed. This review describes the efforts undertaken in vitro and in vivo.

Succinylated heparin monolayer coating vastly increases superparamagnetic iron oxide nanoparticle T2 proton relaxivity

Nanoscale ◽  
2019 ◽  
Vol 11 (27) ◽  
pp. 12905-12914 ◽  
Author(s):  
Manman Xie ◽  
Shijia Liu ◽  
Christopher J. Butch ◽  
Shaowei Liu ◽  
Ziyang Wang ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
Clinical Use ◽  
History Of ◽  
Oxide Nanoparticle ◽  
Superparamagnetic Iron Oxide Nanoparticle

Superparamagnetic iron oxide nanoparticles (SPIONs) have a history of clinical use as contrast agents in T2 weighted MRI, though relatively low T2 relaxivity has caused them to fall out of favor as new faster MRI techniques have gained prominence.

PHOTOCATALYTIC DEGRADATION OF METHYLENE BLUE USING IRON OXIDE NANOPARTICLES SYNTHESIZED USING ANNONA MURICATA LEAF EXTRACT

2020 ◽  
pp. 46-51
Author(s):  
BEENA JOSE ◽  
FEMY THOMAS
Keyword(s):  
Electron Microscopy ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Leaf Extract ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
Annona Muricata ◽  
Aqueous Leaf Extract ◽  
Oxide Nanoparticle ◽  
Uv Visible

Objective: The objective of the present study is the synthesis of iron oxide nanoparticles using Annona muricata aqueous leaf extract, characterization of the synthesized nanoparticles and evaluation of the antibacterial, photocatalytic activity and cytotoxicity. Methods: The iron oxide nanoparticle was synthesized using Annona muricata aqueous leaf extract and the crystal structure of the iron oxide nanoparticle was determined by UV-Visible spectroscopy, Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), X-ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR). The in vitro cytotoxicity of iron oxide nanoparticles was evaluated using Dalton’s lymphoma ascites cells and the antibacterial assay was conducted using agar well diffusion method. Results: The UV-Visible spectrum of iron oxide nanoparticle showed a maximum absorption peak at 265 nm. This is the XRD pattern of iron oxide nanoparticles exhibited a distinct peak at 26.029 (2θ), accounting for crystal plane (211). SEM images revealed that the synthesized iron oxide nanoparticles were aggregated as irregular sphere shapes with rough surfaces. TEM image reveals the size of the synthesized iron oxide nanoparticles are spherical in shape with an average size of 20 nm. Green synthesized iron oxide nanoparticles using Annona muricata leaf extract effectively degraded methylene blue dye. Conclusion: This study showed that the synthesized iron oxide nanoparticles using Annona muricata aqueous leaf extract exhibited pronounced antibacterial, anticancer and photocatatytic activity and can be used in the textile industry for the purification of water contaminated with carcinogenic textile dyes. It can also be used as an external antiseptic in the prevention and treatment of bacterial infections.

scholarly journals Effect of precursor concentration on size evolution of iron oxide nanoparticles

CrystEngComm ◽  
2017 ◽  
Vol 19 (44) ◽  
pp. 6694-6702 ◽  
Author(s):  
Hamed Sharifi Dehsari ◽  
Anielen Halda Ribeiro ◽  
Bora Ersöz ◽  
Wolfgang Tremel ◽  
Gerhard Jakob ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Precursor Concentration ◽  
Nanoparticle Size ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
Size Evolution ◽  
Oxide Nanoparticle ◽  
Precursor Ratio

Changing the precursor concentration to tune the iron-oxide nanoparticle size alters the surfactant/precursor ratio and leads to the observation of two size regimes.

scholarly journals Monocore vs. multicore magnetic iron oxide nanoparticles: uptake by glioblastoma cells and efficiency for magnetic hyperthermia

2017 ◽  
Vol 2 (5) ◽  
pp. 629-639 ◽  
Author(s):  
Gauvin Hemery ◽  
Coralie Genevois ◽  
Franck Couillaud ◽  
Sabrina Lacomme ◽  
Etienne Gontier ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cancer Cell ◽  
Magnetic Fluid ◽  
Magnetic Hyperthermia ◽  
Oxide Nanoparticles ◽  
Proof Of Concept ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Fluid Hyperthermia ◽  
Magnetic Iron Oxide

PEGylated magnetic iron oxide nanoparticles (IONPs) were synthesised with the aim to provide proof of concept results of remote cancer cell killing by magnetic fluid hyperthermia.

scholarly journals Iron oxide nanoparticle incorporated cement mortar composite: correlation between physico-chemical and physico-mechanical properties

2020 ◽  
Vol 1 (6) ◽  
pp. 1835-1840
Author(s):  
Mohammad Valizadeh Kiamahalleh ◽  
Abbas Alishah ◽  
Fereshteh Yousefi ◽  
Saeid Hojjati Astani ◽  
Aliakbar Gholampour ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cement Mortar ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
Hydration Products ◽  
Physico Chemical ◽  
Oxide Nanoparticle ◽  
Mechanical Performances

Incorporation of iron oxide nanoparticles into cement mortar composites enhances the formation of hydration products and the physico-mechanical performances of the composite construct.

A novel iron oxide nanoparticle-based method for the determination of the antioxidant capacity of rapeseed oils at various stages of the refining process

2015 ◽  
Vol 7 (11) ◽  
pp. 4650-4660 ◽  
Author(s):  
Aleksandra Szydłowska-Czerniak ◽  
Anna Łaszewska ◽  
Agnieszka Tułodziecka
Keyword(s):  
Iron Oxide ◽  
Antioxidant Capacity ◽  
Iron Oxide Nanoparticles ◽  
Refining Process ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
Novel Method ◽  
Oxide Nanoparticle ◽  
Capacity Determination

A novel method for antioxidant capacity determination based on the antioxidant-mediated generation and growth of iron oxide nanoparticles was elaborated.

scholarly journals Advances in Magnetic Nanoparticles Engineering for Biomedical Applications—A Review

2021 ◽  
Vol 8 (10) ◽  
pp. 134
Author(s):  
Abdulkader Baki ◽  
Frank Wiekhorst ◽  
Regina Bleul
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Diagnostic Imaging ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Fluid ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Magnetic Fluid Hyperthermia ◽  
Targeted Drug

Magnetic iron oxide nanoparticles (MNPs) have been developed and applied for a broad range of biomedical applications, such as diagnostic imaging, magnetic fluid hyperthermia, targeted drug delivery, gene therapy and tissue repair. As one key element, reproducible synthesis routes of MNPs are capable of controlling and adjusting structure, size, shape and magnetic properties are mandatory. In this review, we discuss advanced methods for engineering and utilizing MNPs, such as continuous synthesis approaches using microtechnologies and the biosynthesis of magnetosomes, biotechnological synthesized iron oxide nanoparticles from bacteria. We compare the technologies and resulting MNPs with conventional synthetic routes. Prominent biomedical applications of the MNPs such as diagnostic imaging, magnetic fluid hyperthermia, targeted drug delivery and magnetic actuation in micro/nanorobots will be presented.

Sign in / Sign up

Export Citation Format

Share Document