A new family of 2-hydroxy fatty acids as a new class of non-steroid anti-inflammatory drugs

2010 ◽  
Vol 163 ◽  
pp. S41 ◽  
Author(s):  
Daniel Horacio López ◽  
María Laura Martín ◽  
María Antonia Noguera-Salva ◽  
Silvia Terés ◽  
Gwendolyn Barceló Coblijn ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Hydroxy Fatty Acids ◽  
New Class ◽  
New Family ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals P045 5-Aminosalicylates promote inflammation resolution in ulcerative colitis through generation of anti-inflammatory hydroxy fatty acids

2017 ◽  
Vol 11 (suppl_1) ◽  
pp. S100-S101
Author(s):  
R. Wysoczanski ◽  
A. Kendall ◽  
M. Motwani ◽  
R. Vega ◽  
F. Rahman ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Fatty Acids ◽  
Hydroxy Fatty Acids ◽  
Anti Inflammatory ◽  
Inflammation Resolution

scholarly journals Reduction of Pulmonary Inflammation by pH Modifiers

2022 ◽  
Author(s):  
Wei-ping Zeng
Keyword(s):  
Pulmonary Inflammation ◽  
Inflammatory Cells ◽  
Pathological Feature ◽  
Successful Therapy ◽  
Mucus Hypersecretion ◽  
Adverse Side Effects ◽  
New Class ◽  
Asthma Model ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Pulmonary inflammation is a common pathological feature of a variety of diseases, ofwhich successful therapy with currently available anti-inflammatory drugs is limited byresistance and adverse side effects. Using the ovalbumin-induced mouse allergic asthma model,the present study shows that treatments with pH modifiers, particularly simple acids such asacetate or hydrochloric acid, effectively depleted inflammatory cells in the lungs and blood aswell as hyperplastic lung tissue cells while preserving the structure of the blood vessels and lungparenchyma. The acid treatments also suppressed mucus hypersecretion. These resultsdemonstrated pH modifiers as a new class of broad-spectrum anti-inflammatory agents with antiproliferationand mucus suppression activities.

Supplementary therapy in canine atopic dermatitis

2019 ◽  
Vol 24 (8) ◽  
pp. 400-407
Author(s):  
Sue Paterson
Keyword(s):  
Fatty Acids ◽  
Atopic Dermatitis ◽  
Specific Immunotherapy ◽  
Essential Fatty Acids ◽  
Topical Therapy ◽  
Allergen Specific Immunotherapy ◽  
Canine Atopic Dermatitis ◽  
Adequate Control ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Therapy for canine atopic dermatitis can be described as foundation or supplementary. Foundation therapy, which refers to allergen-specific immunotherapy, ciclosporin, glucocorticoids, lokivetmab and oclacitinib, is needed in all but the mildest of cases of canine atopic dermatitis. Supplementary therapies include drugs such as antihistamines, essential fatty acids, topical therapy and other systemic anti-inflammatory drugs. While it is uncommon for any of these supplementary drugs to provide adequate control of many cases of canine atopic dermatitis, they can reduce the frequency of relapse and reduce the amount of foundation therapy that is required when used in combination with them.

scholarly journals Chemotherapeutic Properties of Phospho-Nonsteroidal Anti-Inflammatory Drugs, a New Class of Anticancer Compounds

2011 ◽  
Vol 71 (24) ◽  
pp. 7617-7627 ◽  
Author(s):  
Liqun Huang ◽  
Gerardo G. Mackenzie ◽  
Yu Sun ◽  
Nengtai Ouyang ◽  
Gang Xie ◽  
...  
Keyword(s):  
Anticancer Compounds ◽  
New Class ◽  
Inflammatory Drugs ◽  
Anti Inflammatory
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