Dupilumab Improves Asthma Control and Asthma-Related Quality of Life in Uncontrolled Persistent Asthma Patients Across All Baseline Exacerbation Rates

Background: Asthma is a common cause of morbidity and mortality with prevalence of 300 million in world. The QOL of asthmatic patients cannot be determined only on the basis the severity of the disease, but requires a measurement of personal perception. This study was conducted with the aim to assess and compare the QOL using PedsQl scale in asthma patients between 5 to 18 years of age with different demographic and clinical variables.Methods: This was a cross-sectional observational study conducted at respiratory clinic in tertiary hospital, Rewa from October 2017 to June 2019. A total number of 150 asthmatic patients and their parents participated. Asthmatic patients (N=150) and their parents, presenting to asthma clinic of Gandhi Memorial Hospital, Rewa (after applying inclusion-exclusion criteria) were assessed for QOL using PedsQl scale 3.0. Statistical analysis was performed by SPSS version 20. Test of significance by student T-test and one way ANOVA.Results: The QOL is severely hampered by asthma with mean of 59 in intermittent asthma, 51 in mild, 44.74 in moderate and 40 in severe persistent asthma, significant p value of <0.05. Younger age, level of asthma control and severity were significantly related to QOL with p value of <0.05. Sex, socioeconomic status, were insignificantly related.Conclusions: QOL is impaired as the grading of asthma increases. Impairment of Quality of life are mostly associated with low level of asthma control, poly-therapy and frequent night attacks.

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Factors affecting asthma psychomorbidity, control and illness-related quality of life: what is the interaction?

European Psychiatry ◽

10.1016/s0924-9338(11)73449-6 ◽

2011 ◽

Vol 26 (S2) ◽

pp. 1745-1745

Author(s):

N. Pilipenko ◽

M. Karekla

Keyword(s):

Quality Of Life ◽

Asthma Control ◽

Research Literature ◽

Smoking History ◽

Inflammatory Disorder ◽

Chronic Inflammatory Disorder ◽

Asthma Patients ◽

Related Quality ◽

The Impact

Asthma is a chronic inflammatory disorder of the airways, ounknown etiology and growing prevalence (GINA, 2009). Appropriate asthma management can control the disorder and enable patients to enjoy a good quality of life (WHO, 2007).Yet, many asthma patients are unable to maintain asthma control (Rabe et al., 2003) for various reasons, including psychological ones (Feldman et al., 2005).This study examined the prevalence of psychomorbidity, and its interaction with asthma control difficulties and asthma-related quality of life in a sample of 200 asthma patients in Cyprus. Asthma diagnoses and severity were established by medical chart review.Psychomorbidity was evaluated using the Patient Health Questionnaire (Spitzer, 1999). Additionally, the impact of asthma-specific (e.g. asthma knowledge), health-specific (e.g. smoking history) and socio-demographic (e.g. perceived poverty) factors was examined as prior research literature suggests these may significantly impact asthma control and asthma-related quality of life.Currently, the present study is in its final stages of data collection (to conclude 2010). The results will offer valuable insights into the mechanisms and factors which affect asthma control, quality of life, and psychomorbidity. In doing so, the present study will contribute to the improved understanding of asthma patients’ experiences, essential to guide medical and psychological interventions.

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Asthma control, lung function, nutritional status, and health-related quality of life: differences between adult males and females with asthma

Jornal Brasileiro de Pneumologia ◽

10.1590/s1806-37562017000000216 ◽

2018 ◽

Vol 44 (4) ◽

pp. 273-278 ◽

Cited By ~ 1

Author(s):

Gabriele Carra Forte ◽

Maria Luiza Hennemann ◽

Paulo de Tarso Roth Dalcin

Keyword(s):

Quality Of Life ◽

Lung Function ◽

Nutritional Status ◽

Asthma Control ◽

Health Related Quality ◽

Asthma Patients ◽

Related Quality ◽

Health Related ◽

Males And Females

ABSTRACT Objective: To evaluate health-related quality of life in asthma patients treated at a referral center in southern Brazil, identifying differences between male and female patients, as well as to evaluate differences between the males and females in terms of asthma control, lung function, and nutritional status. Methods: This was a cross-sectional study involving patients ≥ 18 years of age treated at an asthma outpatient clinic. We evaluated clinical parameters, lung function, nutritional status, and quality of life. Results: A total of 198 patients completed the study. The mean age was 56.2 ± 14.8 years, and 81.8% were female. The proportion of patients with uncontrolled asthma was higher among females than among males (63.0% vs. 44.4%; p = 0.041). The body mass index (BMI) and percentage of body fat were higher in females than in males (30.2 ± 5.8 kg/m2 vs. 26.9 ± 4.5 kg/m2 and 37.4 ± 6.4% vs. 26.5 ± 7.4%; p = 0.002 and p < 0.001, respectively). Quality of life was lower in females than in males in the following domains: symptoms (3.8 ± 1.5 vs. 4.6 ± 1.7; p = 0.006); activity limitation (3.6 ± 1.3 vs. 4.4 ± 1.5; p = 0.001); emotional function (3.6 ± 1.9 vs. 4.5 ± 1.7; p = 0.014); and environmental stimuli (3.2 ± 1.6 vs. 4.3 ± 1.9; p = 0.001). Conclusions: Male asthma patients appear to fare better than do female asthma patients in terms of health-related quality of life, asthma control, BMI, percentage of body fat, and comorbidities.

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Association of step count with PROMIS health-related quality of life measures in children and adolescents with persistent asthma

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2020.12.533 ◽

2021 ◽

Vol 147 (2) ◽

pp. AB148

Author(s):

Allison Burbank ◽

Michelle Hernandez ◽

Nicole Lucas ◽

Courtney Mann ◽

Li Lin ◽

...

Keyword(s):

Quality Of Life ◽

Children And Adolescents ◽

Persistent Asthma ◽

Step Count ◽

Health Related Quality ◽

Quality Of Life Measures ◽

Related Quality ◽

Health Related

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Inhaled mometasone furoate reduces oral prednisone requirements while improving respiratory function and health-related quality of life in patients with severe persistent asthma

Journal of Allergy and Clinical Immunology ◽

10.1067/mai.2000.110798 ◽

2000 ◽

Vol 106 (5) ◽

pp. 852-860 ◽

Cited By ~ 47

Author(s):

James E. Fish ◽

Jill P. Karpel ◽

Timothy J. Craig ◽

George W. Bensch ◽

Michael Noonan ◽

...

Keyword(s):

Quality Of Life ◽

Respiratory Function ◽

Oral Prednisone ◽

Persistent Asthma ◽

Mometasone Furoate ◽

Health Related Quality ◽

Severe Persistent Asthma ◽

Related Quality ◽

Health Related

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Problem-Solving Skills Training for Vulnerable Families of Children with Persistent Asthma: Report of a Randomized Trial on Health-Related Quality of Life Outcomes

Journal of Pediatric Psychology ◽

10.1093/jpepsy/jsp133 ◽

2010 ◽

Vol 35 (10) ◽

pp. 1133-1143 ◽

Cited By ~ 32

Author(s):

Michael Seid ◽

James W. Varni ◽

Pradeep Gidwani ◽

Leticia Reyes Gelhard ◽

Donald J. Slymen

Keyword(s):

Quality Of Life ◽

Problem Solving ◽

Persistent Asthma ◽

Skills Training ◽

Health Related Quality ◽

Vulnerable Families ◽

Related Quality ◽

Health Related ◽

Parent Proxy

Abstract Objectives To test the efficacy of problem-solving skill training (PST) in improving health-related quality of life (HRQOL) of children with persistent asthma from predominantly lower socioeconomic status (SES) Spanish-speaking Hispanic families. Methods Randomized controlled trial comparing standard care waitlist (SC) control, home-visiting asthma education/care coordination (CC), and combined intervention (CC + PST) at baseline, after intervention, and 6-month follow-up. The primary outcome was parent proxy-report child HRQOL (PedsQL). Results Participants (n = 252) were 83.3% Hispanic and 56.3% monolingual Spanish speakers, and 72.6% of mothers had not graduated high school. We found a significant (P = 0.05) intervention effect for parent proxy-reported child generic (but not asthma-specific) HRQOL, with CC + PST superior to SC [83.8 vs 79.8; adjusted mean difference of 4.05 points (95% confidence interval 0.63–7.4], but no difference between the CC and SC groups. Conclusions In this sample of vulnerable families of children with persistent asthma, a CC + PST intervention was efficacious in improving children’s generic HRQOL.

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