PULMONARY ASPERGILLOSIS LEADING TO DISSEMINATED DISEASE IN AN IMMUNOCOMPETENT PATIENT

The diverse clinicopathological spectrum of pulmonary aspergillosis is a consequence of varying levels of invasiveness of this ubiquitous fungus, which largely depends on the host immune response and pre-existing lung disease. The clinical presentation of pulmonary aspergillosis spans a wide spectrum from hypersensitivity to life threatening angio-invasive and disseminated disease. We report the case of a young immunocompetent male with no underlying lung disease, who presented with an incidentally detected ‘infective mass’ lesion in the lung associated with minimal respiratory symptoms. The diagnostic challenges posed by the unusual clinical, radiological and histological picture as well as the therapeutic dilemmas faced are discussed in this report.

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Airway centered invasive pulmonary aspergillosis in an immunocompetent patient: case report and literature review

Journal of Thoracic Disease ◽

10.21037/jtd.2016.02.23 ◽

2016 ◽

Vol 8 (3) ◽

pp. E250-E254 ◽

Cited By ~ 8

Author(s):

Jun Ho Kim ◽

Hong Lyeol Lee ◽

Lucia Kim ◽

Jung Soo Kim ◽

Yeo Ju Kim ◽

...

Keyword(s):

Case Report ◽

Literature Review ◽

Invasive Pulmonary Aspergillosis ◽

Immunocompetent Patient ◽

Patient Case ◽

Pulmonary Aspergillosis

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Fatal Clinical Course of Probable Invasive Pulmonary Aspergillosis with Influenza B Infection in an Immunocompetent Patient

Tuberculosis and Respiratory Diseases ◽

10.4046/trd.2014.77.3.141 ◽

2014 ◽

Vol 77 (3) ◽

pp. 141 ◽

Cited By ~ 7

Author(s):

Dong Won Park ◽

Ji Young Yhi ◽

Gunwoo Koo ◽

Sung Jun Jung ◽

Hyun Jung Kwak ◽

...

Keyword(s):

Clinical Course ◽

Invasive Pulmonary Aspergillosis ◽

Immunocompetent Patient ◽

Influenza B ◽

Pulmonary Aspergillosis

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Invasive Pulmonary Aspergillosis with Disseminated Infection in Immunocompetent Patient

Canadian Respiratory Journal ◽

10.1155/2016/7984032 ◽

2016 ◽

Vol 2016 ◽

pp. 1-5 ◽

Cited By ~ 8

Author(s):

Gabriel Moreno-González ◽

Antoni Ricart de Mesones ◽

Rachid Tazi-Mezalek ◽

Maria Teresa Marron-Moya ◽

Antoni Rosell ◽

...

Keyword(s):

Fatal Outcome ◽

Invasive Pulmonary Aspergillosis ◽

Healthy Woman ◽

Immunocompetent Patient ◽

Invasive Infection ◽

Aggressive Treatment ◽

Membrane Oxygenator ◽

Pulmonary Aspergillosis ◽

Disseminated Aspergillosis ◽

Very High

Invasive pulmonary aspergillosis (IPA) is a rare pathology with increasing incidence mainly in critical care settings and recently in immunocompetent patients. The mortality of the disease is very high, regardless of an early diagnosis and aggressive treatment. Here, we report a case of a 56 yr old previously healthy woman who was found unconscious at home and admitted to the emergency room with mild respiratory insufficiency. In the first 24 hours she developed an acute respiratory failure with new radiographic infiltrates requiring Intensive Care Unit admission. A severe obstructive pattern with impossibility of ventilation because of bilateral atelectasis was observed, requiring emergent venovenous extracorporeal membrane oxygenator device insertion. Bronchoscopy revealed occlusion of main bronchi, demonstrating by biopsy an invasive infection byAspergillus fumigatusandA. flavus. Despite an aggressive treatment and vital support the patient had a fatal outcome. The forensic study confirms the diagnosis of IPA but also revealed the presence of disseminated aspergillosis.

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Diagnosis of airway-invasive pulmonary aspergillosis by tree-in-bud sign in an immunocompetent patient: Case report and literature review

Journal de Mycologie Médicale ◽

10.1016/j.mycmed.2012.12.050 ◽

2013 ◽

Vol 23 (1) ◽

pp. 64-69 ◽

Cited By ~ 7

Author(s):

X.-Y. Xu ◽

H.-M. Sun ◽

B.-L. Zhao ◽

Yi Shi

Keyword(s):

Case Report ◽

Literature Review ◽

Invasive Pulmonary Aspergillosis ◽

Immunocompetent Patient ◽

Patient Case ◽

Pulmonary Aspergillosis

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First Case of Nocardia pseudobrasiliensis Causing Primary Cutaneous Nocardiosis in an Immunocompetent Patient

Journal of Investigative Medicine High Impact Case Reports ◽

10.1177/2324709620938228 ◽

2020 ◽

Vol 8 ◽

pp. 232470962093822

Author(s):

Shraddhadevi Makadia ◽

Ishan Patel ◽

Ivan Soosaipillai ◽

Aneta Tarasiuk-Rusek

Keyword(s):

Medical History ◽

Causative Agent ◽

Immunocompetent Patient ◽

Causative Organism ◽

Immunocompromised Patients ◽

Past Medical History ◽

Significant Past Medical History ◽

Common Cause ◽

First Case ◽

Disseminated Disease

Nocardia brasiliensis is the most common cause of cutaneous nocardiosis. Nocardia pseudobrasiliensis is an emerging species responsible for invasive and disseminated disease in immunocompromised patients. We describe a case of a 67-year-old immunocompetent patient without significant past medical history diagnosed with primary cutaneous nocardiosis with N pseudobrasiliensis as the causative organism. In our opinion, we report the first case of primary cutaneous nocardiosis in an immunocompetent patient with N pseudobrasiliensis being the causative agent.

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Adrenal histoplasmosis : a rare cause of bilateral adrenomegaly

Journal of Society of Surgeons of Nepal ◽

10.3126/jssn.v17i1.15181 ◽

2016 ◽

Vol 17 (1) ◽

pp. 42-43

Author(s):

PP Subedi ◽

S Chapagain ◽

DK Thakur ◽

S Poudyal ◽

BR Luitel ◽

...

Keyword(s):

Opportunistic Infection ◽

Histoplasma Capsulatum ◽

Immunocompetent Patient ◽

Dimorphic Fungus ◽

Disseminated Disease

Histoplasmosis is an opportunistic infection caused by a dimorphic fungus Histoplasma capsulatum. Histoplasmosis causing bilateral adrenal involvement is rare and usually occurs only in immunocompromised individuals with disseminated disease. Here we report a case of bilateral adrenal histoplasmosis with disseminated disease in an immunocompetent patient.

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