scholarly journals Invasive Pulmonary Aspergillosis with Disseminated Infection in Immunocompetent Patient

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Gabriel Moreno-González ◽  
Antoni Ricart de Mesones ◽  
Rachid Tazi-Mezalek ◽  
Maria Teresa Marron-Moya ◽  
Antoni Rosell ◽  
...  
Keyword(s):  
Fatal Outcome ◽  
Invasive Pulmonary Aspergillosis ◽  
Healthy Woman ◽  
Immunocompetent Patient ◽  
Invasive Infection ◽  
Aggressive Treatment ◽  
Membrane Oxygenator ◽  
Pulmonary Aspergillosis ◽  
Disseminated Aspergillosis ◽  
Very High

Invasive pulmonary aspergillosis (IPA) is a rare pathology with increasing incidence mainly in critical care settings and recently in immunocompetent patients. The mortality of the disease is very high, regardless of an early diagnosis and aggressive treatment. Here, we report a case of a 56 yr old previously healthy woman who was found unconscious at home and admitted to the emergency room with mild respiratory insufficiency. In the first 24 hours she developed an acute respiratory failure with new radiographic infiltrates requiring Intensive Care Unit admission. A severe obstructive pattern with impossibility of ventilation because of bilateral atelectasis was observed, requiring emergent venovenous extracorporeal membrane oxygenator device insertion. Bronchoscopy revealed occlusion of main bronchi, demonstrating by biopsy an invasive infection byAspergillus fumigatusandA. flavus. Despite an aggressive treatment and vital support the patient had a fatal outcome. The forensic study confirms the diagnosis of IPA but also revealed the presence of disseminated aspergillosis.

scholarly journals Airway centered invasive pulmonary aspergillosis in an immunocompetent patient: case report and literature review

2016 ◽  
Vol 8 (3) ◽  
pp. E250-E254 ◽  
Author(s):  
Jun Ho Kim ◽  
Hong Lyeol Lee ◽  
Lucia Kim ◽  
Jung Soo Kim ◽  
Yeo Ju Kim ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Invasive Pulmonary Aspergillosis ◽  
Immunocompetent Patient ◽  
Patient Case ◽  
Pulmonary Aspergillosis

scholarly journals 1707. Invasive Pulmonary Aspergillosis in Patients with Severe Fever with Thrombocytopenia Syndrome

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S625-S626
Author(s):  
Seongman Bae ◽  
Jiwon Jung ◽  
Min Jae Kim ◽  
Eunbeen Cho ◽  
Mi Young Kim ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Fatal Outcome ◽  
Invasive Pulmonary Aspergillosis ◽  
Rank Test ◽  
Care Hospital ◽  
Pulmonary Aspergillosis ◽  
Corticosteroid Administration ◽  
Log Rank Test ◽  
Tick Borne Disease ◽  
Severe Fever

Abstract Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease often accompanied by immune catastrophic course and subsequent fatal outcome. More than 90% of patients with SFTS had leukopenia and about one-third of those need the admission of intensive care unit (ICU) during the hospital course. So, there has been growing concern about the complications such as invasive pulmonary aspergillosis (IPA) in critical SFTS patients. We thus investigate the incidence and clinical characteristics of IPA in patients with SFTS. Methods All patients who were confirmed as SFTS in a tertiary care hospital, Seoul, South Korea, between January 2013 and October 2018 were enrolled. The modified AspICU algorithm was used to identify cases of putative invasive pulmonary aspergillosis (PIPA) and discriminate these invasive diseases from colonization. Results Of the 45 PCR-confirmed SFTS patients, 16 (36%) received ICU care. Of these 16 patients, 9 (56%) developed PIPA during hospitalization. The median duration from admission to the first evidence of PIPA was 8 days (range, 2–11 days). None of the PIPA cases met the revised EORTC/MSG criterion. Septic shock and corticosteroid administration preceded more frequently in PIPA group than non-PIPA group (100% vs. 19%, P < 0.0001 and 67% vs. 14%, P = 0.003, respectively). Patients complicated by PIPA showed significantly higher mortality than non-PIPA patients (44% vs. 8%, P = 0.048 by log-rank test). Mortality was lower in patients with PIPA who received antifungal treatment (17% [1/6]) than in those with PIPA who did not (100% [3/3]) (log-rank test, P = 0.002). Conclusion More than half of patients with SFTS in ICU were complicated by IPA during early hospital course. Cautious scrutiny for IPA in patients with SFTS followed by early appropriate antifungal therapy for IPA is needed. Disclosures All authors: No reported disclosures.

Invasive pulmonary aspergillosis with Aspergillus vertebral osteomyelitis in an HIV-infected adult: a case report

2019 ◽  
Vol 30 (11) ◽  
pp. 1140-1142 ◽  
Author(s):  
Valeria Senosain-Leon ◽  
Aida Hidalgo-Benites ◽  
Jose Arriola-Montenegro ◽  
Lorenzo D’Angelo-Piaggio ◽  
Renato Beas
Keyword(s):  
Diagnostic Tests ◽  
Fatal Outcome ◽  
Vertebral Osteomyelitis ◽  
Invasive Pulmonary Aspergillosis ◽  
Pulmonary Aspergillosis ◽  
Prompt Treatment ◽  
Immunodeficiency Virus ◽  
Amphotericin B Deoxycholate ◽  
Infected Adult ◽  
Immunosuppressed Patients

We report the case of a 29-year-old man with human immunodeficiency virus infection and irregular adherence to antiretroviral therapy who initially presented with pulmonary symptoms and subsequently developed spinal cord compromise symptoms. After many different diagnostic tests, invasive aspergillosis with pleuroparenchymal involvement and vertebral osteomyelitis by Aspergillus spp. was diagnosed. The patient was treated with amphotericin B deoxycholate without improvement and a fatal outcome ensued. Differential diagnoses of vertebral osteomyelitis in immunosuppressed patients should be taken into account for early detection and prompt treatment.

scholarly journals Invasive pulmonary aspergillosis in an immunocompetent patient with severe dengue fever

2014 ◽  
Vol 18 (5) ◽  
pp. 323-325 ◽  
Author(s):  
Ankur Gupta ◽  
Rohit Yadav ◽  
S.K. Nagrani ◽  
Sanjay Raina ◽  
Shakti Jain
Keyword(s):  
Dengue Fever ◽  
Invasive Pulmonary Aspergillosis ◽  
Immunocompetent Patient ◽  
Severe Dengue ◽  
Pulmonary Aspergillosis

scholarly journals Invasive Pulmonary Aspergillosis after Influenza A Infection in an Immunocompetent Patient

2013 ◽  
Vol 75 (6) ◽  
pp. 260 ◽  
Author(s):  
Oh Kyung Kwon ◽  
Myung Goo Lee ◽  
Hyo Sun Kim ◽  
Min Sun Park ◽  
Kyoung Min Kwak ◽  
...  
Keyword(s):  
Influenza A ◽  
Invasive Pulmonary Aspergillosis ◽  
Immunocompetent Patient ◽  
Pulmonary Aspergillosis

scholarly journals Invasive aspergillosis associated with COVID-19

2021 ◽  
Vol 31 (5) ◽  
pp. 671-676
Author(s):  
Nikolay V. Ovsyannikov ◽  
Olga A. Bilevich ◽  
Lyudmila A. Zenkova ◽  
Olga V. Vasilieva
Keyword(s):  
Invasive Aspergillosis ◽  
Fatal Outcome ◽  
Invasive Pulmonary Aspergillosis ◽  
World Health ◽  
Medical Community ◽  
The Novel ◽  
Pulmonary Aspergillosis ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Health Organization

The novel coronavirus (COVID-19) pandemic announced by the World Health Organization in March 2020 has brought new tasks to the medical community that require immediate solutions. Recent studies have shown that invasive aspergillosis associated with coronavirus infection caused by COVID-19 often aggravates the course of the disease and leads to death. The article presents a clinical case of acute invasive aspergillosis in a COVID-19 patient with chronic somatic pathology but no risk factors for developing invasive pulmonary aspergillosis. The disease was progressing rapidly and led to a fatal outcome.Conclusion. In the case presented, invasive pulmonary aspergillosis was diagnosed with the help of histological examination of autopsy material.

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