External mass transfer in high performance liquid chromatography systems

2008 ◽  
Vol 1210 (1) ◽  
pp. 60-67 ◽  
Author(s):  
Kanji Miyabe ◽  
Motoki Ando ◽  
Nobuho Ando ◽  
Georges Guiochon
Keyword(s):  
Mass Transfer ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
External Mass Transfer

scholarly journals Equilibrium and mass transfer parameters estimation of the products of synthesis of piperonal by high performance liquid chromatography

2015 ◽  
Vol 1 (1) ◽  
pp. 01-15
Author(s):  
Alex Martins Ramos ◽  
Marco Aurélio Cremasco
Keyword(s):  
Mass Transfer ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Stationary Phase ◽  
High Performance ◽  
Multicomponent Mixture ◽  
Effective Diffusion ◽  
Internal Resistance ◽  
Parameters Estimation ◽  
Parallel Diffusion

The reaction sequences applied to essential oil of Piper hispidinervum D.C (long pepper) leads to formation of a multicomponent mixture composed, mainly, by piperonal, safrole, isosafrole and terpinolene. Due to importance of the piperonal for the pharmaceutical industry is that proposed separate it by high performance liquid chromatography. In this paper, it was studied the adsorption and mass transfer phenomena of these compounds using ethanol/water 70/30 (v/v) as mobile phase and C18 as stationary phase at 35 oC. Regarding to adsorption, the piperonal is the component that has the lowest affinity and terpinolene, the greatest with stationary phase. Regarding to mass transfer, effective diffusion and axial dispersion coefficients were around 10- (10 to 11) and 10- (7 to 8) m2.s-1, respectively. The internal resistance to mass transfer controls the overall mass transfer and parallel diffusion model describes the intra-particle transport mechanism.

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