A facile organic–silica hybrid monolith was prepared by a thiol-ene click reaction of polyhedral oligomeric silsesquioxane methacryl substituted (POSS-MA) with 1,4-bis(mercaptoacetoxy) butane (BMAB) using toluene and dodecanol as a porogenic system.
Preparation of aptamer-based organic–silica hybrid monolithic capillary column by “thiol–ene” click chemistry for the detection of the enantiomers of chemotherapeutic anthracyclines.