Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) α+β+ transcript in estrogen receptor-positive MCF-7 breast cancer cells

2009 ◽  
Vol 42 (13-14) ◽  
pp. 1358-1362 ◽  
Author(s):  
Areti Strati ◽  
Zoi Papoutsi ◽  
Evi Lianidou ◽  
Paraskevi Moutsatsou
Amino Acids ◽  
2011 ◽  
Vol 42 (2-3) ◽  
pp. 899-911 ◽  
Author(s):  
Irina Nayvelt ◽  
Shali John ◽  
Hui-Chen Hsu ◽  
PingAr Yang ◽  
Wensheng Liu ◽  
...  

2013 ◽  
Vol 41 (1) ◽  
pp. 145-154 ◽  
Author(s):  
Pınar Obakan ◽  
Elif Damla Arısan ◽  
Pelin Özfiliz ◽  
Ajda Çoker-Gürkan ◽  
Narçin Palavan-Ünsal

2011 ◽  
Vol 89 (1) ◽  
pp. 50-57 ◽  
Author(s):  
Ada Popolo ◽  
Anna Lisa Piccinelli ◽  
Silvana Morello ◽  
Rosalinda Sorrentino ◽  
Cuesta Rubio Osmany ◽  
...  

Estrogen receptor (ER) antagonists have been widely used for breast cancer treatment; however, patients have increasingly shown resistance and sensitivity to the high toxicity of these drugs, and identification of novel targeted therapies is therefore required. To determine whether nemorosone, a polycyclic polyisoprenylated benzophenone isolated from floral resins of Clusia rosea Jacq. and Cuban propolis samples, exerts anticancer effects on human breast cancer cells, estrogen receptor positive (ERα+) MCF-7 and estrogen receptor negative (ERα–) MDA-MB-231 and LNCaP cells were used. Cells were treated with nemorosone alone or in association with 17β-estradiol (E2) or an ER antagonist, ICI 182,780, a selective ER downregulator that completely abrogates estrogen-sensitive gene transcription. Nemorosone inhibited the cell viability of ERα+ but not of ERα– cells. In MCF-7, nemorosone induced inhibition of cell growth by blocking the cell cycle in the G0/G1 phase. Moreover, the expression of pERK1/2 and pAkt, considered to be hallmarks of the nongenomic estrogen signalling pathway, were reduced in MCF-7 cells treated with nemorosone. All these effects were enhanced by ICI 182,780. However, nemorosone was not able to interfere with E2-induced Ca2+ release. These findings suggest that nemorosone may have therapeutic application in the treatment of breast cancer because of its activity on ERα.


2017 ◽  
Vol 20 (1) ◽  
pp. 20 ◽  
Author(s):  
Mohammad Alaee ◽  
Shahnaz Khaghani ◽  
Kiarash Behroozfar ◽  
Zahra Hesari ◽  
Seyedeh Sara Ghorbanhosseini ◽  
...  

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