Increased low-density lipoprotein oxidation, but not total plasma protein oxidation, in Alzheimer's disease

2010 ◽  
Vol 43 (3) ◽  
pp. 267-271 ◽  
Author(s):  
Sarah Aldred ◽  
Stuart Bennett ◽  
Patrizia Mecocci
Keyword(s):  
Alzheimer’S Disease ◽  
Plasma Protein ◽  
Protein Oxidation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Total Plasma ◽  
Lipoprotein Oxidation ◽  
Total Plasma Protein ◽  
Low Density Lipoprotein Oxidation

scholarly journals Protective Effect of Lusianthridin on Hemin-Induced Low-Density Lipoprotein Oxidation

2021 ◽  
Vol 14 (6) ◽  
pp. 567
Author(s):  
Su Wutyi Thant ◽  
Noppawan Phumala Morales ◽  
Visarut Buranasudja ◽  
Boonchoo Sritularak ◽  
Rataya Luechapudiporn
Keyword(s):  
Foam Cell ◽  
Low Density Lipoprotein ◽  
Cell Formation ◽  
Density Lipoprotein ◽  
Foam Cell Formation ◽  
Raw 264.7 ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Raw 264.7 Macrophage Cells ◽  
Low Density Lipoprotein Oxidation

Oxidation of low-density lipoprotein (LDL) plays a crucial role in the pathogenesis of atherosclerosis. Hemin (iron (III)-protoporphyrin IX) is a degradation product of hemoglobin that can be found in thalassemia patients. Hemin is a strong oxidant that can cause LDL oxidation and contributes to atherosclerosis in thalassemia patients. Lusianthridin from Dendrobium venustrum is a phenolic compound that possesses antioxidant activity. Hence, lusianthridin could be a promising compound to be used against hemin-induced oxidative stress. The major goal of this study is to evaluate the protective effect of lusianthridin on hemin-induced low-density lipoprotein oxidation (he-oxLDL). Here, various concentrations of lusianthridin (0.25, 0.5, 1, and 2 µM) were preincubated with LDL for 30 min, then 5 µM of hemin was added to initiate the oxidation, and oxidative parameters were measured at various times of incubation (0, 1, 3, 6, 12, 24 h). Lipid peroxidation of LDL was measured by thiobarbituric reactive substance (TBARs) assay and relative electrophoretic mobility (REM). The lipid composition of LDL was analyzed by using reverse-phase HPLC. Foam cell formation with he-oxLDL in RAW 264.7 macrophage cells was detected by Oil Red O staining. The results indicated that lusianthridin could inhibit TBARs formation, decrease REM, decrease oxidized lipid products, as well as preserve the level of cholesteryl arachidonate and cholesteryl linoleate. Moreover, He-oxLDL incubated with lusianthridin for 24 h can reduce the foam cell formation in RAW 264.7 macrophage cells. Taken together, lusianthridin could be a potential agent to be used to prevent atherosclerosis in thalassemia patients.

scholarly journals Multiple mechanisms for inhibition of low density lipoprotein oxidation by novel cyclic nitrone spin traps.

1994 ◽  
Vol 269 (45) ◽  
pp. 28055-28061
Author(s):  
C E Thomas ◽  
D F Ohlweiler ◽  
B Kalyanaraman
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Spin Traps ◽  
Low Density Lipoprotein Oxidation

Stimulation of low-density lipoprotein oxidation by insulin and insulin like growth factor I

1994 ◽  
Vol 107 (1) ◽  
pp. 99-108 ◽  
Author(s):  
Vincent A. Rifici ◽  
Stephen H. Schneider ◽  
Avedis K. Khachadurian
Keyword(s):  
Growth Factor ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Insulin Like Growth Factor ◽  
Lipoprotein Oxidation ◽  
Factor I ◽  
Growth Factor I ◽  
Low Density Lipoprotein Oxidation ◽  
Stimulation Of

Low-density lipoprotein oxidation in essential hypertension

1993 ◽  
Vol 11 (10) ◽  
pp. 1103-1111 ◽  
Author(s):  
Elena Maggi ◽  
Eugenia Marchesi ◽  
Valentina Ravetta ◽  
Francesco Falaschi ◽  
Giorgio Finardi ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Low Density Lipoprotein Oxidation

scholarly journals Low density lipoprotein oxidation in children

1998 ◽  
Vol 38 (2) ◽  
pp. 207-208
Author(s):  
L. Iughetti ◽  
C. Volta ◽  
E. Maggi ◽  
G. Bellomo ◽  
S. Bernasconi
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Low Density Lipoprotein Oxidation

Comparison of HOCl traps with myeloperoxidase inhibitors in prevention of low density lipoprotein oxidation

2000 ◽  
Vol 1481 (1) ◽  
pp. 109-118 ◽  
Author(s):  
Andreas Jerlich ◽  
Gerhard Fritz ◽  
Hadi Kharrazi ◽  
Michal Hammel ◽  
Sylvia Tschabuschnig ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Low Density Lipoprotein Oxidation

scholarly journals Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury.

1991 ◽  
Vol 11 (6) ◽  
pp. 1700-1711 ◽  
Author(s):  
G Balla ◽  
H S Jacob ◽  
J W Eaton ◽  
J D Belcher ◽  
G M Vercellotti
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Endothelial Injury ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Low Density Lipoprotein Oxidation
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