scholarly journals Determining histone H4 acetylation patterns in human peripheral blood mononuclear cells using mass spectrometry

2020 ◽  
Vol 15 ◽  
pp. 54-60
Author(s):  
Esther Marie Bux ◽  
Victor Solis-Mezarino ◽  
Christoph Kuhm ◽  
Bernd H. Northoff ◽  
Ivan Karin ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Histone H4 ◽  
Peripheral Blood Mononuclear ◽  
Histone H4 Acetylation ◽  
Blood Mononuclear Cells

scholarly journals Concerted mass spectrometry-based glycomic approach for precision mapping of sulfo sialylated N-glycans on human peripheral blood mononuclear cells and lymphocytes

Glycobiology ◽  
2017 ◽  
Vol 28 (1) ◽  
pp. 9-20 ◽  
Author(s):  
Jian-You Chen ◽  
Hsin-Hung Huang ◽  
Shin-Yi Yu ◽  
Shang-Ju Wu ◽  
Reiji Kannagi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

scholarly journals Colonic Bacteria-Transformed Catechin Metabolite Response to Cytokine Production by Human Peripheral Blood Mononuclear Cells

Biomolecules ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 830 ◽  
Author(s):  
Rajapandiyan Krishnamoorthy ◽  
Abdulraheem R. Adisa ◽  
Vaiyapuri Subbarayan Periasamy ◽  
Jegan Athinarayanan ◽  
Subash-Babu Pandurangan ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Immune Response ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Peripheral Blood Mononuclear ◽  
Chromatography Mass Spectrometry ◽  
Blood Mononuclear Cells ◽  
Anti Inflammatory

Human gut microbes are a profitable tool for the modification of food compounds into biologically active metabolites. The biological properties of catechins have been extensively investigated. However, the bioavailability of catechin in human blood plasma is very low. This study aimed to determine the biotransformed catechin metabolites and their bioactive potentials for modulating the immune response of human peripheral blood mononuclear cells (PBMCs). Biotransformation of catechin was carried out using in-vitro gut microbial biotransformation method, the transformed metabolites were identified and confirmed by gas chromatography-mass spectrometry (GC–MS) and high-performance liquid chromatography-mass spectrometry (HPLC–MS). Present observations confirmed that the catechin was biotransformed into 11 metabolites upon microbial dehydroxylation and C ring cleavage. Further, immunomodulatory potential of catechin metabolites was analyzed in peripheral blood mononuclear cells (PBMCs). We found up-regulation of anti-inflammatory cytokine (IL-4, IL-10) and down-regulation of pro-inflammatory (IL-16, IL-12B) cytokine may be due to Th2 immune response. In conclusion, biotransformed catechin metabolites enhance anti-inflammatory cytokines which is beneficial for overcoming inflammatory disorders.

THRB expression is affected by miR-26a and miR-496, but age-associated decrease of the expression of this gene in human peripheral blood mononuclear cells is not dependent on these miRNAs

2014 ◽  
Author(s):  
Eliza Pawlik-Pachucka ◽  
Monika Budzinska ◽  
Anna Domaszewska-Szostek ◽  
Magdalena Owczarz ◽  
Magdalena Gewartowska ◽  
...  
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

Hyperglycemia Activates the CD27-CD70 Axis on Human Peripheral Blood Mononuclear Cells

2020 ◽  
pp. ascls.119.002089
Author(s):  
Claire Owaja ◽  
Evelyn Roback-Navarro ◽  
Naomi Iwai ◽  
Nadine Lerret
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

Immunomodulatory Effects of Lactic Acid Bacteria on Human Peripheral Blood Mononuclear Cells

2003 ◽  
Vol 15 (4) ◽  
Author(s):  
J. Michalkiewicz ◽  
M. Krotkiewski ◽  
L. Gackowska ◽  
M. Wyszomirska-Golda ◽  
A. Helmin-Basa ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Immunomodulatory Effects ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells
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