Reduced habituation of the retinal ganglion cell response to sustained pattern stimulation in multiple sclerosis patients

2013 ◽  
Vol 124 (8) ◽  
pp. 1652-1658 ◽  
Author(s):  
Antonello Fadda ◽  
Antonio Di Renzo ◽  
Francesco Martelli ◽  
Dario Marangoni ◽  
Anna Paola Batocchi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Response ◽  
Retinal Ganglion ◽  
Pattern Stimulation ◽  
Multiple Sclerosis Patients

Longitudinal Study of Retinal Ganglion Cell Layer Thickness by OCT in Multiple Sclerosis (S48.003)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. S48.003-S48.003
Author(s):  
E. Davies ◽  
H. Ishikawa ◽  
K. Galetta ◽  
R. Sakai ◽  
D. Feller ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Longitudinal Study ◽  
Ganglion Cell ◽  
Layer Thickness ◽  
Retinal Ganglion Cell ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Layer

Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis

2006 ◽  
Vol 12 (5) ◽  
pp. 526-532 ◽  
Author(s):  
Kenneth S Shindler ◽  
Yangtai Guan ◽  
Elvira Ventura ◽  
Jean Bennett ◽  
Abdolmohamad Rostami
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Neuronal Loss ◽  
Proteolipid Protein ◽  
Cell Loss ◽  
Retinal Ganglion ◽  
Acute Optic Neuritis ◽  
Demyelinating Lesions

Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are marked by inflammatory demyelinating lesions throughout the central nervous system, including optic nerve. Neuronal loss also occurs in MS and EAE lesions, but it is not known whether neuronal loss occurs secondary to inflammation, or as a primary process. In the current study, the relationship of inflammation to retinal ganglion cell (RGC) loss during acute optic neuritis is examined. RGCs were labelled with Flourogold, and EAE was induced in SJL/J mice by immunization with proteolipid protein peptide 139- 151 (PLP). At various time points, RGCs were counted and optic nerves were examined for inflammatory cell infiltrates. No optic neuritis was detected prior to day 9 following immunization. Incidence of optic neuritis was 30% at day 9 and increased to over 70% by day 11, remaining high through day 18. In contrast, no RGC loss was detected in eyes with optic neuritis until day 14. A 43.1% reduction in RGC numbers at day 14 increased to 50.8% by day 18. No RGC loss occurred in eyes without optic neuritis. The fact that inflammation precedes RGC loss suggests that neuronal loss during optic neuritis occurs secondary to the inflammatory process.

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