P4. Contrast-enhancing lesions within the spinal chord help to identify IRIS in patients with natalizumab-PML

2015 ◽  
Vol 126 (8) ◽  
pp. e90
Author(s):  
J. Marquetand ◽  
F. Bischof ◽  
T. Nägele
Keyword(s):  
2012 ◽  
Vol 13 (4) ◽  
pp. S60
Author(s):  
S. Griffee ◽  
N. Buckalew
Keyword(s):  

2006 ◽  
Vol 34 (1) ◽  
pp. 249-268
Author(s):  
Linda M. Austin

THE IDEA OF THE SELFin its various constructions–political, economic, psychological–has always been shadowed by an English tradition of skepticism about the persistence of a conscious and stable identity. Voiced most disconcertingly by David Hume in his section, “Of personal identity” fromA Treatise of Human Nature(1739–40; I.iv.vi), this attitude was significantly advanced during the second half of the nineteenth century by a group of physiological psychologists who argued for the corporeal basis of mental functions, including memory. Henry Maudsley and George Henry Lewes, among others, challenged the metaphysical notion of a mind and drew instead from controversial and often suppressed theories of neuroscience to describe the physiological operation of memory. These theories, which located impressions and sensations in the brain or spinal chord, produced a form of identity that could endure alterations of consciousness. They offered, in addition, a new understanding of an adult's physical connection to the personal past.


1853 ◽  
Vol 143 ◽  
pp. 347-356 ◽  

When I had the honour of laying before the Royal Society my former researches on the structure of the spinal chord, I intimated an intention of preparing another communication on the structure of the medulla oblongata and cerebellum; but as many important points in the minute anatomy of the chord still remained in obscurity, I thought it advisable to make them first the subject of special inquiry, as far as the new method I employed would enable me to proceed. Moreover, as all investiga­tions into the structure of any organ have, or ought to have, for their object a clearer and better knowledge of its functions, I have undertaken also to communicate in this paper whatever physiological deductions may appear to follow from my observa­tions. Having no particular theory to support, and being influenced in these inquiries by no other feeling than the simple desire to elicit truth, the greatest care has been taken to verify my facts, and caution has been exercised in drawing conclusions from them. It is a question of great interest and physiological importance, whether the roots of the spinal nerves belong exclusively to the spinal chord, or whether part of them ascend within either the white or the grey columns, and form the channels by which impressions are transmitted to and from the brain. On account of its interest and importance, I have employed much time and labour in endeavouring to arrive at some well-grounded and settled conclusion on this very difficult subject, having devoted to it alone many hours daily for nearly five months. So extremely intricate, however, is the internal structure of the chord; so numerous are the planes in which the nerve-roots enter the grey substance; and so various are the directions which they pursue within it, that notwithstanding the perfect transparency of my prepara­tions, and the sharp outline which their fibres retain, my efforts to determine the exact relation between these roots and the white and grey columns appeared for some time almost hopeless; but by varying my dissections according to the exigencies of each case of difficulty, I succeeded in arriving at several results which I believe will be considered important.


Author(s):  
Stephen Gaukroger

Phantom limbs pose a philosophical problem about the location of pains. The work of Descartes first used them to make a philosophical point about the brain in relation to the body. They have traditionally been thought of as being due to nerve endings on the pathway to the original limb being activated. However, it was subsequently discovered that the phenomenon occurs even when the spinal chord is severed, suggesting that it is rather a question of brain activity, part of a neurosignature through which the brain indicates the body is one’s own. More recent resarch suggests involvement not only of the sensory systems but also the parietal cortex and the limbic system, which is concerned with emotion and motivation.


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