Environmental lead toxicity and nutritional factors

2007 ◽  
Vol 26 (4) ◽  
pp. 400-408 ◽  
Author(s):  
Maqusood Ahamed ◽  
Mohd. Kaleem Javed Siddiqui
Keyword(s):  
Lead Toxicity ◽  
Nutritional Factors ◽  
Environmental Lead

An Intra-Erythrocytic Low Molecular Weight Lead-Binding Protein in Acute and Chronic Lead Exposure and its Possible Protective Role in Lead Toxicity

1988 ◽  
Vol 25 (6) ◽  
pp. 688-697 ◽  
Author(s):  
Yvette Lolin ◽  
Patrick O'Gorman
Keyword(s):  
Molecular Weight ◽  
Lead Exposure ◽  
Lead Toxicity ◽  
Blood Lead ◽  
Protective Role ◽  
Low Molecular Weight ◽  
Molecular Weight Protein ◽  
Environmental Lead ◽  
Weight Protein ◽  
Low Molecular Weight Protein

A low-molecular-weight protein was measured in erythrocytes from workers with chronic and recent lead exposure, with and without clinical lead toxicity, and from a group of control subjects not exposed to undue environmental lead. The protein was detected in all the workers, but in significantly smaller amounts in those with symptoms, and was absent from controls. The synthesis of the protein is induced at blood lead concentrations above 1·9 μmol/L, but is reduced in workers susceptible to clinical lead toxicity at blood lead concentrations below 4·0 μmol/L. The activity of the red blood cell dithiothreitol (DTT)—activated 5-aminolaevulinate dehydratase (ALA-D) was correlated with the concentration of the low-molecular-weight protein, with both being particularly low in the symptomatic workers. Previous studies have shown that the protein binds lead. By sequestrating excess lead into a non-toxic form, the protein may have a protective role in preventing clinical, and reducing biochemical, lead toxicity.

scholarly journals Prevalence of Lead Toxicity in Adolescents in Kuwait

2020 ◽  
Author(s):  
Reem Jallad ◽  
Muddanna Rao ◽  
Abdur Rahman
Keyword(s):  
Public Health ◽  
Health Problem ◽  
Inductively Coupled Plasma ◽  
Public Health Intervention ◽  
Public Health Problem ◽  
Lead Toxicity ◽  
Population Exposure ◽  
Environmental Lead ◽  
Multi Stage ◽  
Pb Exposure

Abstract Background: Environmental lead (Pb) exposure is a public health problem in many developing and industrialized countries. Being a petrochemical industry-based economy, Pb levels are expected to be high in Kuwait but systematic data on population exposure are lacking. This study aimed at determining the prevalence of Pb toxicity in adolescents in Kuwait.Methods: Adolescents (N=1385; age range 11-16 years) were cross-sectionally selected from public middle schools from all Governorates of Kuwait, utilizing multi-stage cluster random sampling. Pb in whole blood was analyzed by inductively coupled plasma mass spectrometry. Pb levels among Governorates and genders were compared by median test and the prevalence of Pb levels above the CDC cutoff (≥5 µg/dL) was estimated by x2 test. Multiple logistic regression was used for association between prevalence of high Pb levels and Governorate.Results: Median (IQR) Pb was 5.1(3.6 – 7.1) µg/dL [4.9 (3.8 6.5) µg/dL in males and 5.4 (3.3-7.6) µg/dL in females; p=0.001]. In the overall sample, 51% had Pb levels ≥5 µg/dL; 13% were ≥10 µg/dL and 3% >20 µg/dL. Prevalence of Pb ≥5 µg/dL was 47% in males and 56% in females (p<0.001). High Pb levels were clustered in Al-Asima and Al-Ahmadi (in both genders); Al-Jahra (in males) and Mubarak Al-Kabeer (in females) Governorates.Conclusion: Pb exposure is a significant public health problem in adolescents in Kuwait. Urgent public health intervention is required in high Pb exposure areas and further research is needed to identify the sources of exposure in these areas for prevention.

Environmental lead toxicity in cattle

1980 ◽  
Vol 25 (1) ◽  
pp. 142-145 ◽  
Author(s):  
Ramesh V. Bhat ◽  
K. A. V. R. Krishnamachari
Keyword(s):  
Lead Toxicity ◽  
Environmental Lead

scholarly journals Relationship between blood Lead status and anemia in Ugandan children with malaria infection

2020 ◽  
Author(s):  
Ambrose K Mukisa ◽  
Denis M Kasozi ◽  
Claire Aguttu ◽  
Peter C. Vuzi ◽  
Joseph Kyambadde
Keyword(s):  
Iron Deficiency ◽  
Malaria Infection ◽  
Venous Blood ◽  
Lead Toxicity ◽  
Blood Lead ◽  
Statistical Correlation ◽  
P Value ◽  
Lead Pollution ◽  
Environmental Lead ◽  
Moderate Anemia

Abstract BackgroundIn Uganda, childhood anemia remains a health challenge and is associated with malaria infection as well as iron deficiency. Iron deficiency is intertwined with nutritional status, age and other comorbidities including helminths and Lead toxicity. Environmental Lead levels accounts for one’s blood Lead (BL) levels. Blood Lead competitively blocks iron absorption, inhibits hemoglobin (Hb) biosynthesis and elevates free erythrocyte protoporphyrin (FEP) levels. Lead toxicity’s contribution towards anemia pathogenesis, especially during malaria infection has not been studied. Concomitant exposure to both malaria infection and Lead pollution, exacerbates the anemia status. This study therefore aimed at expounding the anemia status of these Ugandan children aged under 5years who are exposed to both malaria infection and environmental Lead pollution.MethodsBriefly, venous blood samples from 198 children were microscopically assayed for malaria parasite density (PD), and hemoglobin (Hb) concentrations using the cyanmethemoglobin method, while BL and FEP levels were determined by the standard atomic absorption spectrophotometric and fluorometric methods respectively.ResultsOne hundred and fifty-one (76.3%) of the children analyzed had moderate anemia (Hb <10>5 g/dL) with Means of BLL=8.6 µg/dL, Hb =7.5 g/dL, FEP/Hb =8.3 µg/g and PD =3.21×103 parasites / µL, while eight (4%) were severely anemic (<5 g/dL). Regression analysis and statistical correlation between PD and Hb (r = -0.231, R2= 0.15 P-value < 0.001) was negative and weak as compared to that between FEP/Hb and Hb (r = -0.6, R2=0.572 P-value=0.001).ConclusionBased on the study’s findings, we conclude that BL significantly contributes to the pathogenesis of anemia and therefore its co-existence with malaria infection in the host exacerbates the anemia status.Trial registration Not applicable

scholarly journals Relationship between blood Lead status and anemia in Ugandan children with malaria infection

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ambrose Mukisa ◽  
Denis Kasozi ◽  
Claire Aguttu ◽  
Peter C. Vuzi ◽  
Joseph Kyambadde
Keyword(s):  
Iron Deficiency ◽  
Malaria Infection ◽  
Venous Blood ◽  
Lead Toxicity ◽  
Blood Lead ◽  
Statistical Correlation ◽  
P Value ◽  
Lead Pollution ◽  
Environmental Lead ◽  
Moderate Anemia

Abstract Background In Uganda, childhood anemia remains a health challenge and is associated with malaria infection as well as iron deficiency. Iron deficiency is intertwined with nutritional status, age and other comorbidities including helminths and Lead toxicity. Environmental Lead levels accounts for one’s blood Lead (BL) levels. Blood Lead competitively blocks iron absorption, inhibits hemoglobin (Hb) biosynthesis and elevates free erythrocyte protoporphyrin (FEP) levels. Lead toxicity’s contribution towards anemia pathogenesis, especially during malaria infection has not been studied. Concomitant exposure to both malaria infection and Lead pollution, exacerbates the anemia status. This study therefore aimed at expounding the anemia status of these Ugandan children aged under 5years who are exposed to both malaria infection and environmental Lead pollution. Methods Briefly, venous blood samples from 198 children were microscopically assayed for malaria parasite density (PD), and hemoglobin (Hb) concentrations using the cyanmethemoglobin method, while BL and FEP levels were determined by the standard atomic absorption spectrophotometric and fluorometric methods respectively. Results One hundred and fifty-one (76.3%) of the children analyzed had moderate anemia (Hb <10>5 g/dL) with Means of BLL=8.6 µg/dL, Hb =7.5 g/dL, FEP/Hb =8.3 µg/g and PD =3.21×103 parasites / µL, while eight (4%) were severely anemic (<5 g/dL). Regression analysis and statistical correlation between PD and Hb (r = -0.231, R2= 0.15 P-value < 0.001) was negative and weak as compared to that between FEP/Hb and Hb (r = -0.6, R2=0.572 P-value=0.001). Conclusion Based on the study’s findings, we conclude that BL significantly contributes to the pathogenesis of anemia and therefore its co-existence with malaria infection in the host exacerbates the anemia status.

scholarly journals An electrophysiological assessment of subclinical lead toxicity in children

2017 ◽  
Vol 6 (1) ◽  
pp. 23-26
Author(s):  
Mohammad Sayeed Hassan ◽  
Sheikh Farjana Sonia ◽  
Ferdous Ara ◽  
Md Abdullah Yusuf ◽  
Ahmad Raihan Sharif ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Primary School ◽  
Lead Level ◽  
Lead Toxicity ◽  
Primary School Children ◽  
P Value ◽  
Nerve Function ◽  
Environmental Lead ◽  
Significant Difference ◽  
Peripheral Nerve Function

Background: While heavy exposure to inorganic lead is capable of inducing symptomatic neuropathy, subclinical neuropathy due to low level of lead exposure remains to be proved.Objectives: This study was assessed peripheral nerve function in environmental lead exposed primary school children.Methods: Electrophysiological evaluation of peripheral nerve function was done in 17 subclinical lead exposed and 17 non-exposed primary school children in an urban industrial area of Dhaka. Lead exposed children had mean blood lead level (BLL) 20.2 (±5.17) ?gm/ dl. Non-exposed children had BLL 6.2 (±2.82) ?gm/ dl.Results: Electrophysiological evaluation of peripheral nerve function was normal in lead exposed children. Statistical analysis also did not show any significant difference in parameters of nerve function between lead exposed and non-exposed children (p value >0.05).Conclusion: This study did not find any electrophysiological evidence of peripheral nerve dysfunction in the environmental lead exposed children compared to nonexposed.J Shaheed Suhrawardy Med Coll, June 2014, Vol.6(1); 23-26

scholarly journals Relationship between blood Lead status and anemia in Ugandan children with malaria infection

2020 ◽  
Author(s):  
Ambrose K Mukisa ◽  
Denis M Kasozi ◽  
Claire Aguttu ◽  
Peter C. Vuzi ◽  
Joseph Kyambadde
Keyword(s):  
Iron Deficiency ◽  
Malaria Infection ◽  
Venous Blood ◽  
Lead Toxicity ◽  
Blood Lead ◽  
Statistical Correlation ◽  
P Value ◽  
Lead Pollution ◽  
Environmental Lead ◽  
Moderate Anemia

Abstract Background In Uganda, childhood anemia remains a health challenge and is associated with malaria infection as well as iron deficiency. Iron deficiency is intertwined with nutritional status, age and other comorbidities including helminths and Lead toxicity. Environmental Lead levels accounts for one’s blood Lead (BL) levels. Blood Lead competitively blocks iron absorption, inhibits hemoglobin (Hb) biosynthesis and elevates free erythrocyte protoporphyrin (FEP) levels. Lead toxicity’s contribution towards anemia pathogenesis, especially during malaria infection has not been studied. Concomitant exposure to both malaria infection and Lead pollution, exacerbates the anemia status. This study therefore aimed at expounding the anemia status of these Ugandan children aged under 5years who are exposed to both malaria infection and environmental Lead pollution. Methods Briefly, venous blood samples from 198 children were microscopically assayed for malaria parasite density (PD), and hemoglobin (Hb) concentrations using the cyanmethemoglobin method, while BL and FEP levels were determined by the standard atomic absorption spectrophotometric and fluorometric methods respectively. Results One hundred and fifty-one (76.3%) of the children analyzed had moderate anemia (Hb <10>5 g/dL) with Means of BLL=8.6 µg/dL, Hb =7.5 g/dL, FEP/Hb =8.3 µg/g and PD =3.21×103 parasites / µL, while eight (4%) were severely anemic (<5 g/dL). Regression analysis and statistical correlation between PD and Hb (r = -0.231, R2= 0.15 P-value < 0.001) was negative and weak as compared to that between FEP/Hb and Hb (r = -0.6, R2=0.572 P-value=0.001). Conclusion Based on the study’s findings, we conclude that BL significantly contributes to the pathogenesis of anemia and therefore its co-existence with malaria infection in the host exacerbates the anemia status.Trial registration Not applicable

Lead and lead toxicity in domestic and free living birds

2003 ◽  
Vol 32 (1) ◽  
pp. 3-13 ◽  
Author(s):  
N. De Francisco ◽  
N. De Francisco ◽  
N. De Francisco
Keyword(s):  
Lead Toxicity ◽  
Free Living
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