Common polymorphism in the cannabinoid receptor gene type 2 (CB2R) rs3123554 are associated with metabolic changes after two different hypocaloric diets with different dietary fatty profiles

2019 ◽  
Vol 38 (6) ◽  
pp. 2632-2638
Author(s):  
R. Aller ◽  
D. Primo ◽  
O. Izaola ◽  
D.A. de Luis
Keyword(s):  
Cannabinoid Receptor ◽  
Receptor Gene ◽  
Metabolic Changes ◽  
Common Polymorphism ◽  
Gene Type

Polymorphism rs3123554 in the cannabinoid receptor gene type 2 ( CNR2 ) reveals effects on body weight and insulin resistance in obese subjects

2017 ◽  
Vol 64 (8) ◽  
pp. 440-445 ◽  
Author(s):  
Daniel Antonio de Luis ◽  
Olatz Izaola ◽  
David Primo ◽  
Beatriz de la Fuente ◽  
Rocio Aller
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Cannabinoid Receptor ◽  
Receptor Gene ◽  
Gene Type ◽  
Obese Subjects

A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human

2007 ◽  
Vol 29 (2) ◽  
pp. 99-108 ◽  
Author(s):  
R. M. Salek ◽  
M. L. Maguire ◽  
E. Bentley ◽  
D. V. Rubtsov ◽  
T. Hough ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Multivariate Statistics ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Nucleotide Metabolism ◽  
Metabolic Changes ◽  
Stress Changes

Type 2 diabetes mellitus is the result of a combination of impaired insulin secretion with reduced insulin sensitivity of target tissues. There are an estimated 150 million affected individuals worldwide, of whom a large proportion remains undiagnosed because of a lack of specific symptoms early in this disorder and inadequate diagnostics. In this study, NMR-based metabolomic analysis in conjunction with multivariate statistics was applied to examine the urinary metabolic changes in two rodent models of type 2 diabetes mellitus as well as unmedicated human sufferers. The db/db mouse and obese Zucker ( fa/fa) rat have autosomal recessive defects in the leptin receptor gene, causing type 2 diabetes. 1H-NMR spectra of urine were used in conjunction with uni- and multivariate statistics to identify disease-related metabolic changes in these two animal models and human sufferers. This study demonstrates metabolic similarities between the three species examined, including metabolic responses associated with general systemic stress, changes in the TCA cycle, and perturbations in nucleotide metabolism and in methylamine metabolism. All three species demonstrated profound changes in nucleotide metabolism, including that of N-methylnicotinamide and N-methyl-2-pyridone-5-carboxamide, which may provide unique biomarkers for following type 2 diabetes mellitus progression.

Impact of reference gene selection for type 2 cannabinoid receptor gene expression studies in human spermatozoa

Andrologia ◽  
2012 ◽  
Vol 45 (4) ◽  
pp. 278-284 ◽  
Author(s):  
A. A. Amoako ◽  
A. K. Gebeh ◽  
E. L. Marczylo ◽  
J. M. Willets ◽  
J. Elson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Reference Gene ◽  
Gene Selection ◽  
Cannabinoid Receptor ◽  
Receptor Gene ◽  
Expression Studies ◽  
Selection For ◽  
Gene Expression Studies ◽  
Receptor Gene Expression
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