High cholesterol and triglyceride levels are mainly related to further generation of lifethreating
metabolism disorders including cardiovascular system diseases. Therefore,
hypercholesterolemia (i.e., also referred to as hyperlipoproteinemia) is a serious disease state, which
must be controlled. Currently, the treatment of hypercholesterolemia is mainly achieved through the
employment of statins in the clinic, although there are alternative drugs (e.g., ezetimibe,
cholestyramine). In fact, the original statins are natural products directly obtained from fungi-like
molds and mushrooms and they are potent inhibitors of hydroxymethylglutaryl-CoA reductase, the
key enzyme in the biosynthesis of cholesterol. This review focuses on the first identification of
natural statins, their synthetic and semi-synthetic analogues, and the validation of
hydroxymethylglutaryl-CoA reductase as a target in the treatment of hypercholesterolemia.
Furthermore, other natural products that have been shown to possess the potential to inhibit
hydroxymethylglutaryl-CoA reductase are also reviewed with respect to their chemical structures.
Hydroxymethylglutaryl-CoA reductase inhibitors (statins) for the treatment of sepsis in adults – A systematic review and meta-analysis
