scholarly journals Defining a master curve of abdominal aortic aneurysm growth and its potential utility of clinical management

2021 ◽  
pp. 106256
Author(s):  
Emrah Akkoyun ◽  
Hamidreza Gharahi ◽  
Sebastian T. Kwon ◽  
Byron A. Zambrano ◽  
Akshay Rao ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Clinical Management ◽  
Master Curve ◽  
Potential Utility ◽  
Abdominal Aortic ◽  
Aneurysm Growth

scholarly journals Complement Factor C5a Is Increased in Blood of Patients with Abdominal Aortic Aneurysm and Has Prognostic Potential for Aneurysm Growth

2020 ◽  
Author(s):  
Branislav Zagrapan ◽  
Wolf Eilenberg ◽  
Andreas Scheuba ◽  
Johannes Klopf ◽  
Annika Brandau ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Leukotriene B4 ◽  
Complement Factor ◽  
Diagnosis And Prognosis ◽  
Abdominal Aortic ◽  
Aneurysm Growth ◽  
Log Linear

AbstractIn this observational case-control study, circulating levels of complement factors C3a and C5a and leukotriene B4 (LTB4) were analysed in abdominal aortic aneurysm (AAA) patients regarding their association with diagnosis and prognosis. Serum C5a was significantly raised in AAA patients compared to healthy controls—median 84.5 ng/ml (IQR = 37.5 ng/ml) vs. 67.7 ng/ml (IQR = 26.2 ng/ml), p = 0.007—but was not elevated in patients with athero-occlusive disease. Serum C5a levels correlated significantly with the increase in maximum AAA diameter over the following 6 months (r = 0.319, p = 0.021). The median growth in the lowest quartile of C5a (< 70 ng/ml) was 50% less compared to the highest C5a quartile (> 101 ng/ml): 1.0 mm/6 months (IQR = 0.8 mm) vs. 2.0 mm/6 months (IQR = 1.5 mm), p = 0.014. A log-linear mixed model predicted AAA expansion based on current diameter and C5a level. To our knowledge, this is the first study linking complement activation, in particular C5a serum level, with AAA progression. Graphical Abstract

Abstract 297: Segmental Aortic Stiffening is a Mechanism Driving Early Abdominal Aortic Aneurysm Pathogenesis

2014 ◽  
Vol 34 (suppl_1) ◽  
Author(s):  
Uwe Raaz ◽  
Alexander M Zöllner ◽  
Ryuji Toh ◽  
Futoshi Nakagami ◽  
Isabel N Schellinger ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Aortic Wall ◽  
Ex Vivo ◽  
Wall Stress ◽  
Finite Elements Analysis ◽  
External Application ◽  
Abdominal Aortic ◽  
Aneurysm Growth ◽  
Aortic Stiffening

Stiffening of the aortic wall is a phenomenon consistently observed in abdominal aortic aneurysm (AAA). However, its role in AAA pathophysiology is largely undefined. Using an established murine elastase-induced AAA model, we demonstrate that segmental aortic stiffening (SAS) precedes aneurysm growth. Finite elements analysis (FEA)-based wall stress calculations reveal that early stiffening of the aneurysm-prone aortic segment leads to axial (longitudinal) stress generated by cyclic (systolic) tethering of adjacent, more compliant wall segments. Interventional stiffening of AAA-adjacent segments (via external application of surgical adhesive) significantly reduces aneurysm growth. These changes correlate with reduced segmental stiffness of the AAA-prone aorta (due to equalized stiffness in adjacent aortic segments), reduced axial wall stress, decreased production of reactive oxygen species (ROS), attenuated elastin breakdown, and decreased expression of inflammatory cytokines and macrophage infiltration, as well as attenuated apoptosis within the aortic wall. Cyclic pressurization of stiffened aortic segments ex vivo increases the expression of genes related to inflammation and extracellular matrix (ECM) remodeling. Finally, human ultrasound studies reveal that aging, a significant AAA risk factor, is accompanied by segmental infrarenal aortic stiffening. The present study introduces the novel concept of segmental aortic stiffening (SAS) as an early pathomechanism generating aortic wall stress and thereby triggering AAA growth. Therefore monitoring SAS by ultrasound might help to better identify patients at risk for AAA disease and better predict the susceptibility of small AAA to further growth. Moreover our results suggest that interventional mechanical stiffening of the AAA-adjacent aorta may be further tested as a novel treatment option to limit early AAA growth.

scholarly journals Metformin Prescription Associated with Reduced Abdominal Aortic Aneurysm Growth Rate and Reduced Chemokine Expression in a Swedish Cohort

2021 ◽  
Vol 70 ◽  
pp. 425-433 ◽  
Author(s):  
Jon Unosson ◽  
Dick Wågsäter ◽  
Niclas Bjarnegård ◽  
Rachel De Basso ◽  
Martin Welander ◽  
...  
Keyword(s):  
Growth Rate ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Chemokine Expression ◽  
Abdominal Aortic ◽  
Aneurysm Growth ◽  
Swedish Cohort

scholarly journals Prediction of Abdominal Aortic Aneurysm Growth Using Dynamical Gaussian Process Implicit Surface

2019 ◽  
Vol 66 (3) ◽  
pp. 609-622 ◽  
Author(s):  
Huan N. Do ◽  
Ahsan Ijaz ◽  
Hamidreza Gharahi ◽  
Byron Zambrano ◽  
Jonguen Choi ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Gaussian Process ◽  
Implicit Surface ◽  
Abdominal Aortic ◽  
Aneurysm Growth

scholarly journals Local Wall Thickness in Finite Element Models Improves Prediction of Abdominal Aortic Aneurysm Growth

2013 ◽  
Vol 57 (5) ◽  
pp. 78S-79S
Author(s):  
Eric K. Shang ◽  
Derek P. Nathan ◽  
Ronald M. Fairman ◽  
Edward Y. Woo ◽  
Grace J. Wang ◽  
...  
Keyword(s):  
Finite Element ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Wall Thickness ◽  
Finite Element Models ◽  
Abdominal Aortic ◽  
Aneurysm Growth

Clinical management of the symptomatic but unruptured abdominal aortic aneurysm

1990 ◽  
Vol 11 (6) ◽  
pp. 799-803 ◽  
Author(s):  
Cornelius A. Sullivan ◽  
Michael J. Rohrer ◽  
Bruce S. Cutler
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Clinical Management ◽  
Abdominal Aortic

scholarly journals Prediction of Abdominal Aortic Aneurysm Growth and Risk of Rupture in the Era of Machine Learning

Angiology ◽  
2020 ◽  
Vol 71 (8) ◽  
pp. 767-767
Author(s):  
Fabien Lareyre ◽  
Cédric Adam ◽  
Marion Carrier ◽  
Juliette Raffort
Keyword(s):  
Machine Learning ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Abdominal Aortic ◽  
Risk Of Rupture ◽  
Aneurysm Growth
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