Functionalization of iron oxide nanoparticles with small molecules and the impact on reactive oxygen species generation for potential cancer therapy

2019 ◽  
Vol 576 ◽  
pp. 9-14 ◽  
Author(s):  
Trang Mai ◽  
J. Zach Hilt
Keyword(s):  
Reactive Oxygen Species ◽  
Iron Oxide ◽  
Cancer Therapy ◽  
Small Molecules ◽  
Iron Oxide Nanoparticles ◽  
Reactive Oxygen Species Generation ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
The Impact ◽  
Potential Cancer

Glucose oxidase and polydopamine functionalized iron oxide nanoparticles: combination of the photothermal effect and reactive oxygen species generation for dual-modality selective cancer therapy

2019 ◽  
Vol 7 (13) ◽  
pp. 2190-2200 ◽  
Author(s):  
Tiantian Zhang ◽  
Yinping Li ◽  
Weiying Hong ◽  
Zhiyong Chen ◽  
Peng Peng ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Iron Oxide ◽  
Cancer Therapy ◽  
Glucose Oxidase ◽  
Reactive Oxygen Species Generation ◽  
Photothermal Effect ◽  
Ros Generation ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
Anti Cancer

The combination of PTT and ROS generation results in selective anti-cancer effects.

scholarly journals Activatable Superparamagnetic Iron Oxide Nanoparticles Scavenge Reactive Oxygen Species in Macrophages and Endothelial Cells

2020 ◽  
Author(s):  
Chukwuazam Nwasike ◽  
Eunsoo Yoo ◽  
Erin Purr ◽  
Amber L. Doiron
Keyword(s):  
Reactive Oxygen Species ◽  
Endothelial Cells ◽  
Iron Oxide ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Reactive Oxygen ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Oxygen Species

<p>This study centers around diagnostic medicine, and severity staging of inflammatory diseases. Previously, we showed that complexation of PEG and Poly(gallol) on superparamagnetic iron oxide nanoparticles turn OFF the MRI contrasting ability of the nanoparticle. However, in the presence of reactive oxygen species, the contrast agent will turn ON. In this article, for the first time, we provide evidence that our MRI contrast agent is sensitive to physiologically relevant ROS and induces antioxidant activity on immune and endothelial cells. This study provides initial evidence of IPC-SPIOs cellular ROS sensitivity and potential activatable properties in biological conditions.</p>

scholarly journals Accelerated generation of free radicals by iron oxide nanoparticles in the presence of an alternating magnetic field

RSC Advances ◽  
2015 ◽  
Vol 5 (24) ◽  
pp. 18888-18893 ◽  
Author(s):  
Robert J. Wydra ◽  
Catherine E. Oliver ◽  
Kimberly W. Anderson ◽  
Thomas D. Dziubla ◽  
J. Zach Hilt
Keyword(s):  
Magnetic Field ◽  
Reactive Oxygen Species ◽  
Free Radicals ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Reactive Oxygen ◽  
Alternating Magnetic Field ◽  
Oxide Nanoparticles ◽  
Oxygen Species

The catalytic generation of reactive oxygen species from the surface of iron oxide nanoparticles is enhanced through the activated heating with exposure to an alternating magnetic field.

scholarly journals Activatable Superparamagnetic Iron Oxide Nanoparticles Scavenge Reactive Oxygen Species in Macrophages and Endothelial Cells

2020 ◽  
Author(s):  
Chukwuazam Nwasike ◽  
Eunsoo Yoo ◽  
Erin Purr ◽  
Amber L. Doiron
Keyword(s):  
Reactive Oxygen Species ◽  
Endothelial Cells ◽  
Iron Oxide ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Reactive Oxygen ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Oxygen Species

<p>This study centers around diagnostic medicine, and severity staging of inflammatory diseases. Previously, we showed that complexation of PEG and Poly(gallol) on superparamagnetic iron oxide nanoparticles turn OFF the MRI contrasting ability of the nanoparticle. However, in the presence of reactive oxygen species, the contrast agent will turn ON. In this article, for the first time, we provide evidence that our MRI contrast agent is sensitive to physiologically relevant ROS and induces antioxidant activity on immune and endothelial cells. This study provides initial evidence of IPC-SPIOs cellular ROS sensitivity and potential activatable properties in biological conditions.</p>

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