Impact of bulk and surface properties of some biocompatible hydrophobic polymers on the stability of methylene chloride-in-water mini-emulsions used to prepare nanoparticles by emulsification–solvent evaporation

2007 ◽  
Vol 59 (2) ◽  
pp. 194-207 ◽  
Author(s):  
Valery G. Babak ◽  
Francis Baros ◽  
Omar Boulanouar ◽  
Frank Boury ◽  
Michel Fromm ◽  
...  
Keyword(s):  
Surface Properties ◽  
Methylene Chloride ◽  
Solvent Evaporation ◽  
Hydrophobic Polymers ◽  
Emulsification Solvent Evaporation ◽  
The Stability

scholarly journals Comparative Nanofabrication of PLGA-Chitosan-PEG Systems Employing Microfluidics and Emulsification Solvent Evaporation Techniques

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1882
Author(s):  
Divesha Essa ◽  
Yahya E. Choonara ◽  
Pierre P. D. Kondiah ◽  
Viness Pillay
Keyword(s):  
Surface Charge ◽  
Surface Properties ◽  
Surface Characteristics ◽  
Solvent Evaporation ◽  
Physical Interaction ◽  
Scanning Calorimetry ◽  
Particle Properties ◽  
Superior Surface ◽  
Poorly Soluble ◽  
Emulsification Solvent Evaporation

Poor circulation stability and inadequate cell membrane penetration are significant impediments in the implementation of nanocarriers as delivery systems for therapeutic agents with low bioavailability. This research discusses the fabrication of a biocompatible poly(lactide-co-glycolide) (PLGA) based nanocarrier with cationic and hydrophilic surface properties provided by natural polymer chitosan and coating polymer polyethylene glycol (PEG) for the entrapment of the hydrophobic drug disulfiram. The traditional emulsification solvent evaporation method was compared to a microfluidics-based method of fabrication, with the optimisation of the parameters for each method, and the PEGylation densities on the experimental nanoparticle formulations were varied. The size and surface properties of the intermediates and products were characterised and compared by dynamic light scattering, scanning electron microscopy and X-ray diffraction, while the thermal properties were investigated using thermogravimetric analysis and differential scanning calorimetry. Results showed optimal particle properties with an intermediate PEG density and a positive surface charge for greater biocompatibility, with nanoparticle surface characteristics shielding physical interaction of the entrapped drug with the exterior. The formulations prepared using the microfluidic method displayed superior surface charge, entrapment and drug release properties. The final system shows potential as a component of a biocompatible nanocarrier for poorly soluble drugs.

Effect of the type of hydrophobic polymers on the size of nanoparticles obtained by emulsification–solvent evaporation

2003 ◽  
Vol 13 (2) ◽  
pp. 65-67 ◽  
Author(s):  
Yulia V. Chernysheva ◽  
Valery G. Babak ◽  
Natalia R. Kildeeva ◽  
Franck Boury ◽  
Jean P. Benoit ◽  
...  
Keyword(s):  
Solvent Evaporation ◽  
Hydrophobic Polymers ◽  
Emulsification Solvent Evaporation

scholarly journals Stability of dental implants with sandblasted and acid-etched (SLA) and modified (SLActive) surfaces during the osseointegration period

2021 ◽  
Vol 15 (4) ◽  
pp. 226-231
Author(s):  
Gulsum Sayin Ozel ◽  
Ozgur Inan ◽  
Asli Secilmis Acar ◽  
Gamze Alniacik Iyidogan ◽  
Dogan Dolanmaz ◽  
...  
Keyword(s):  
Dental Implants ◽  
Surface Properties ◽  
Resonance Frequency Analysis ◽  
Implant Stability ◽  
Osteoprogenitor Cells ◽  
Implant Placement ◽  
Modified Surfaces ◽  
Surface Measurements ◽  
The Stability ◽  
Over Time

Background. The surface properties of implants are effective factors for increasing the osseointegration and activity of osteoprogenitor cells. This study compared the stability of dental implants with sandblasted and acid-etched (SLA) and modified surfaces (SLActive) using the resonance frequency analysis (RFA). Methods. In a split-mouth design, 50 dental implants with either SLA surface properties (n=25) or modified (SLActive) surface properties (n=25) were placed in the mandibles of 12 patients with a bilateral posterior edentulous area. Implant stability was measured using RFA (Osstell) at implant placement time and every week for 1, 2, and 3 months before the conventional loading time. Results. One week following the implantation, implant stability increased from 70 to 77.67 for SLA and from 71.67 to 79 for SLActive (P<0.05). Stability improved each week except in the 4th week in SLActive surface measurements. No significant differences were observed between the groups at 2 and 3 months (P>0.05). Conclusions. For both implant surfaces, increased stability was observed over time, with no significant differences between the groups.

Surface properties of fumed silica/pyrocarbon prepared by pyrolysis of methylene chloride

2003 ◽  
Vol 82 (1) ◽  
pp. 199-205 ◽  
Author(s):  
O. Seledets ◽  
J. Skubiszewska-Zięba ◽  
R. Leboda ◽  
V.M. Gun’ko
Keyword(s):  
Surface Properties ◽  
Fumed Silica ◽  
Methylene Chloride

Importance of bacterial surface properties to control the stability of emulsions

2006 ◽  
Vol 112 (1) ◽  
pp. 26-34 ◽  
Author(s):  
Mai Huong Ly ◽  
Murielle Naïtali-Bouchez ◽  
Thierry Meylheuc ◽  
Marie-Noëlle Bellon-Fontaine ◽  
Thanh Mai Le ◽  
...  
Keyword(s):  
Surface Properties ◽  
Bacterial Surface ◽  
The Stability

Surface Properties of TiN Films on AZ 31 Magnesium Alloys Deposited by Magnetron Sputtering Technique

2011 ◽  
Vol 314-316 ◽  
pp. 53-57 ◽  
Author(s):  
Xiang Rong Zhu ◽  
Nai Ci Bing ◽  
Zhong Ling Wei ◽  
Qiu Rong Chen
Keyword(s):  
Magnetron Sputtering ◽  
Surface Properties ◽  
Structural Defects ◽  
Micro Hardness ◽  
Dense Structure ◽  
Tin Films ◽  
Tin Film ◽  
Indentation Experiment ◽  
The Stability ◽  
Electronic Microscope

TiN films were deposited on the AZ 31 magnesium alloy substrates by d.c. magnetron sputtering technique. The surface properties of the films were investigated. The scanning electronic microscope observations reveal the dense structure characteristics of as-deposited TiN films. Under 200°C heat treatment for 30 minutes or 4 times’ heat cycles at 85°C for one hour, no structural defects such as cracks are observed on the surface of the films. Adhesion experiment further demonstrates the stability of the film and the strong combination between the film and the substrate. Nano-indentation experiment shows that the average micro-hardness of TiN film reaches 23.85 Gpa. Finally, the corrosion experiments in simulated body fluid initially reveal the degradation property of TiN film.

Effect of post-synthesis treatment on the stability and surface properties of MCM-48 silica

2005 ◽  
Vol 83 (1-3) ◽  
pp. 172-180 ◽  
Author(s):  
Anne Galarneau ◽  
Marie-France Driole ◽  
Carolina Petitto ◽  
Bich Chiche ◽  
Barbara Bonelli ◽  
...  
Keyword(s):  
Surface Properties ◽  
The Stability ◽  
Post Synthesis

scholarly journals FORMULASI MIKROPARTIKEL BERPORI DALAM POLI (D,L-Laktida) SEBAGAI SCAFFOLDDENGAN TEKNIK EMULSIFIKASI PENGUAPAN PELARUT

2015 ◽  
Vol 4 (2) ◽  
pp. 7
Author(s):  
Lili Fitriani ◽  
Tri Suciati
Keyword(s):  
Particle Size ◽  
Sodium Bicarbonate ◽  
Solvent Evaporation ◽  
Burst Release ◽  
Target Tissue ◽  
Citric Acid Solution ◽  
Porous Microparticles ◽  
Optimum Formulation ◽  
Oil Water ◽  
Emulsification Solvent Evaporation

 ABSTRACT Poly (D,L-lactide acid) has been used as scaffold for tissue engineering. In this study, PDLLA microparticles were made into porous microparticles. Porous microparticles were proposed to reduce burst release of protein and to prevent diffusion of released protein into non-target tissue. Formulation of porous microparticles was made by water-oil-water (W1/O/W2) emulsification-solvent evaporation using gas foamed as porogen. Variations of the amount of sodium bicarbonate, volume of citric acid solution and time for homogenization were optimized to produce optimum formulation. Evaluation for this microparticles included morphology of particles, particle size distribution and porosity. Porous microparticle produced by ratio volume of acid : dichloromethane : poly(vynil alcohol) (PVA) = 1:3:3 and the ratio of  sodium bicarbonate : PDLLA = 2:3 was the optimum formulation.  Keywords :Porous Microparticles, PDLLA,Gas Foamed, Scaffold, Solvent Evaporation 

Sign in / Sign up

Export Citation Format

Share Document