Bionic tracheal tissue regeneration using a ring-shaped scaffold comprised of decellularized cartilaginous matrix and silk fibroin

2021 ◽  
pp. 109470
Author(s):  
Erji Gao ◽  
Gao Li ◽  
Runfeng Cao ◽  
Huitang Xia ◽  
Yong Xu ◽  
...  
Keyword(s):  
Silk Fibroin ◽  
Tissue Regeneration ◽  
Cartilaginous Matrix ◽  
Tracheal Tissue

Biomimetic silk fibroin and xanthan gum blended hydrogels for connective tissue regeneration

2020 ◽  
Vol 165 ◽  
pp. 874-882
Author(s):  
Prasanna Kumar Byram ◽  
Krishna Chaitanya Sunka ◽  
Anwesha Barik ◽  
Manish Kaushal ◽  
Santanu Dhara ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Silk Fibroin ◽  
Tissue Regeneration ◽  
Xanthan Gum ◽  
Connective Tissue Regeneration

Silk fibroin membrane used for guided bone tissue regeneration

2017 ◽  
Vol 70 ◽  
pp. 148-154 ◽  
Author(s):  
Yurong Cai ◽  
Junmao Guo ◽  
Cen Chen ◽  
Chenxue Yao ◽  
Sung-Min Chung ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Silk Fibroin ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration

scholarly journals Silk Fibroin/Collagen/Chitosan Scaffolds Cross-Linked by a Glyoxal Solution as Biomaterials toward Bone Tissue Regeneration

Materials ◽  
2020 ◽  
Vol 13 (15) ◽  
pp. 3433
Author(s):  
Sylwia Grabska-Zielińska ◽  
Alina Sionkowska ◽  
Catarina C. Coelho ◽  
Fernando J. Monteiro
Keyword(s):  
Mechanical Properties ◽  
Silk Fibroin ◽  
Tissue Regeneration ◽  
Three Dimensional ◽  
Bone Tissue Regeneration ◽  
New Materials ◽  
Swelling Degree ◽  
Chitosan Scaffolds ◽  
Measured Density ◽  
Scanning Electron

In this study, three-dimensional materials based on blends of silk fibroin (SF), collagen (Coll), and chitosan (CTS) cross-linked by glyoxal solution were prepared and the properties of the new materials were studied. The structure of the composites and the interactions between scaffold components were studied using FTIR spectroscopy. The microstructure was observed using a scanning electron microscope. The following properties of the materials were measured: density and porosity, moisture content, and swelling degree. Mechanical properties of the 3D materials under compression were studied. Additionally, the metabolic activity of MG-63 osteoblast-like cells on materials was examined. It was found that the materials were characterized by a high swelling degree (up to 3000% after 1 h of immersion) and good porosity (in the range of 80–90%), which can be suitable for tissue engineering applications. None of the materials showed cytotoxicity toward MG-63 cells.

The use of sulfonated silk fibroin derivatives to control binding, delivery and potency of FGF-2 in tissue regeneration

Biomaterials ◽  
2010 ◽  
Vol 31 (6) ◽  
pp. 1403-1413 ◽  
Author(s):  
Esther Wenk ◽  
Amanda R. Murphy ◽  
David L. Kaplan ◽  
Lorenz Meinel ◽  
Hans P. Merkle ◽  
...  
Keyword(s):  
Silk Fibroin ◽  
Tissue Regeneration

scholarly journals MP30-09 BI-LAYER SILK FIBROIN GRAFTS PROMOTE TISSUE REGENERATION IN A FETAL OVINE MODEL OF BLADDER EXSTROPHY

2016 ◽  
Vol 195 (4S) ◽  
Author(s):  
Saif Affas ◽  
Khalid Algarrahi ◽  
Debra Franck ◽  
Yeun Goo Chung ◽  
Dario Fauza ◽  
...  
Keyword(s):  
Silk Fibroin ◽  
Tissue Regeneration ◽  
Bladder Exstrophy ◽  
Ovine Model

scholarly journals Regeneration of Tracheal Tissue in Partial Defects Using Porcine Small Intestinal Submucosa

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Nelson Bergonse Neto ◽  
Lianna Ferrari Jorge ◽  
Julio C. Francisco ◽  
Bruna Olandoski Erbano ◽  
Barbara Evelin Gonçalves Barboza ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Histological Analysis ◽  
Rabbit Model ◽  
Small Intestinal Submucosa ◽  
Control Group ◽  
Surgical Tracheostomy ◽  
Porcine Small Intestinal Submucosa ◽  
Tracheal Tissue ◽  
Small Intestinal ◽  
Intestinal Submucosa

Background. Surgical correction of tracheal defects is a complex procedure when the gold standard treatment with primary end-to-end anastomosis is not possible. An alternative treatment may be the use of porcine small intestinal submucosa (SIS). It has been used as graft material for bioengineering applications and to promote tissue regeneration. The aim of this study was to evaluate whether SIS grafts improved tracheal tissue regeneration in a rabbit model of experimental tracheostomy. Methods. Sixteen rabbits were randomized into two groups. Animals in the control group underwent only surgical tracheostomy, while animals in the SIS group underwent surgical tracheostomy with an SIS graft covering the defect. We examined tissues at the site of tracheostomy 60 days after surgery using histological analysis with hematoxylin and eosin (H&E) staining and analyzed the perimeter and area of the defect with Image-Pro® PLUS 4.5 (Media Cybernetics). Results. The average perimeter and area of the defects were smaller by 15.3% (p=0.034) and 21.8% (p=0.151), respectively, in the SIS group than in the control group. Histological analysis revealed immature cartilage, pseudostratified ciliated epithelium, and connective tissue in 54.5% (p=0.018) of the SIS group, while no cartilaginous regeneration was observed in the control group. Conclusions. Although tracheal SIS engraftment could not prevent stenosis in a rabbit model of tracheal injury, it produced some remarkable changes, efficiently facilitating neovascularization, reepithelialization, and neoformation of immature cartilage.

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