Evaluation of density variations to determine impact on sterile compounding

Purpose To determine the density variation between (1) the measured density and manually calculated density, (2) density variation of different lots, and (3) density variation of different drug manufacturers in order to support institutions using gravimetric compounding methods. Summary Seventeen sterile injectable ingredient (drug) vials frequently used to make compounded sterile products (CSPs) were identified based on the ability to ensure that for each drug there were vials produced by 2 different manufacturers and 2 lots produced by the same manufacturer. Each drug’s density was measured using a density meter and by manual calculation using the institution’s density formula. Density differences were compared between the 2 different methods. Overall, the average drug density difference between the measured versus calculated density was determined to be 0.022. Further analysis revealed the average difference between the different lot numbers of the same manufacturers was 0.005 for the nonhazardous drugs and 0.0001 for the hazardous drugs. The average difference between the different manufacturers of the same drug was determined to be 0.008 for the nonhazardous drugs and 0.001 for hazardous drugs. Conclusion No clinically meaningful difference exists when manually calculating a drug’s density compared to measuring a drug’s density using a density meter. In addition, there does not appear to be a sizeable density variation between the same drugs in separate lots or produced by different manufacturers.

Performance of Carbon Fiber Filament Reinforcing Cement Mortar

This paper aims to study the effect of Carbon Fiber Filament (CFF) with different ratios and lengths on the physical and mechanical properties of cement mortar. An experimental program included 3 cm fixed length of CFF with 0, 0.25, 0.5, 0.75, and 1% different ratios by weight of cement addition were used in cement mortar cubes. Another experimental program of 0.5% CFF ratio with 1, 2, 3, 4, and 5 cm different lengths by weight of cement addition was used in cement mortar prisms. The physical and mechanical properties of cement mortar containing CFF were experimentally investigated at 7 and 28 days of curing. Workability, by means of flow table test, were measured. Density is conducted for cubes and prisms at the age of 28 days. At ages of 7 and 28 days, compressive and flexural strengths were studied. The study showed a reduction in workability with the increase of CFF ratios and lengths by 0.0 to 2.7% and by 0.9 to 5.4% respectively. Moreover, an improvement in density, compressive, and flexural strengths was observed. At ages of 7 and 28 days, the results showed that compressive strength increased by 33 and 31% respectively at 0.5% of CFF ratio while the flexural strength increased by 125 and 327% respectively with CFF length of 5 cm. Doi: 10.28991/cej-2021-03091753 Full Text: PDF

Hydrostatic differential meter of local density of natural waters

Variants of constructing meters of local density of natural waters in deep-water instruments are proposed. In the first variant, the density of water is determined as the sum of the density of the reference liquid in a vertical tube with access in the middle of the tube of external pressure and the weighted sum of the readings of differential pressure sensors at the ends of the tube. The second version contains two identical basic or simplified meters with different densities of the reference liquid. In the third variant, n primary meters are used, from which n sub-bands or 2 С n results of pairwise measurements are formed. In the fourth version, one or more primary or simplified meters are used, which are adjusted to the measured density by changing the temperature.

Density spikes in Titan’s upper ionosphere

<p>Titan, the largest moon of Saturn, has a dense and nitrogen-rich atmosphere, which is similar to that of early Earth before lived evolved. Solar EUV radiation and energetic particles ionizes the atmosphere and thereby forming a layer of plasma, the ionosphere, in the uppermost part of the atmosphere. The Cassini spacecraft flew past the moon Titan 127 times during its 14-year mission in the Saturn system. During most of these close flybys Cassini entered the ionosphere and some reached the ionospheric peak, located at some 1400 km above the moon surface. With the Langmuir probe instrument, we could study the plasma properties, e.g. ion and electron density, temperature etc., and a very dynamic ionospheric structure was found. In particular, significant and apparently sporadic density spikes in the upper ionosphere were found. These density peaks are manifested as a sudden increase in the measured density by some 10-100 cm<sup>-3</sup> over a time period of roughly minutes. These have so far been left unattended in our studies of Titan. We will present some statistics on their appearance and initial result on the mechanism forming them.</p> <p> </p> <p> </p>

Monteneroite, Cu2+Mn2+2(AsO4)2⋅8H2O, a new vivianite-structure mineral with ordered cations from the Monte Nero mine, Liguria, Italy

Monteneroite (IMA2020-028), Cu2+Mn2+2(AsO4)2⋅8H2O, is a new vivianite-structure mineral from the Monte Nero mine, Rocchetta di Vara, La Spezia, Liguria, Italy. It is a secondary mineral that crystallised from As-, Cu- and Mn-rich fluids and it is associated with braunite, copper, cuprite, rhodochrosite and strashimirite. Monteneroite occurs as light green, thick blades up to ~2.5 mm long. The streak is white. Crystals are transparent with vitreous lustre. The mineral has Mohs hardness of 2, is somewhat sectile, exhibits two cleavages ({010} perfect and {001} fair) and has irregular stepped fracture. The measured density is 2.97(2) g cm–3. Monteneroite is optically biaxial (+), with α = 1.604(2), β = 1.637(2) and γ = 1.688(2), determined in white light; 2V = 80(1)°; slight dispersion is r < v, orientation: X = b; Z ^ c = 52° in obtuse β. Electron microprobe analyses provided the empirical formula (Cu2+0.88Mn2+0.11)Σ0.99Mn2+2.00(As1.00O4)2⋅8H2O. Monteneroite is monoclinic, C2/m, a = 10.3673(14), b = 13.713(2), c = 4.8420(8) Å, β = 105.992(8)°, V = 661.72(18) Å3 and Z = 2. Monteneroite has a vivianite-type structure (R1 = 0.0535 for 534 I > 2σI reflections). It is the first mineral with this structure type to be defined with ordered octahedral cation sites.

Silk Fibroin/Collagen/Chitosan Scaffolds Cross-Linked by a Glyoxal Solution as Biomaterials toward Bone Tissue Regeneration

In this study, three-dimensional materials based on blends of silk fibroin (SF), collagen (Coll), and chitosan (CTS) cross-linked by glyoxal solution were prepared and the properties of the new materials were studied. The structure of the composites and the interactions between scaffold components were studied using FTIR spectroscopy. The microstructure was observed using a scanning electron microscope. The following properties of the materials were measured: density and porosity, moisture content, and swelling degree. Mechanical properties of the 3D materials under compression were studied. Additionally, the metabolic activity of MG-63 osteoblast-like cells on materials was examined. It was found that the materials were characterized by a high swelling degree (up to 3000% after 1 h of immersion) and good porosity (in the range of 80–90%), which can be suitable for tissue engineering applications. None of the materials showed cytotoxicity toward MG-63 cells.

Smamite, Ca2Sb(OH)4[H(AsO4)2]·6H2O, a new mineral and a possible sink for Sb during weathering of fahlore

Smamite, Ca2Sb(OH)4[H(AsO4)2]·6H2O, is a new mineral species from the Giftgrube mine, Rauenthal, Sainte-Marie-Aux-Mines ore-district, Haut-Rhin department, France. It is a supergene mineral found in quartz-carbonate gangue with disseminated to massive tennantite-tetrahedrite series minerals, native arsenic, Ni-Co arsenides, and supergene minerals picropharmacolite, fluckite, and pharmacolite. Smamite occurs as lenticular crystals growing in aggregates up to 0.5 mm across. The new mineral is whitish to colorless, transparent with vitreous luster and white streak; non-fluorescent under UV radiation. The Mohs hardness iŝ3½; the tenacity is brittle, the fracture is curved, and there is no apparent cleavage. The measured density is 2.72(3) g/cm3; the calculated density is 2.709 g/cm3 for the ideal formula. The mineral is insoluble in H2O and quickly soluble in dilute (10%) HCl at room temperature. Optically, smamite is biaxial (–), α = 1.556(1), β = 1.581(1), γ = 1.588(1) (white light). The 2V (meas) = 54(1)°; 2V (calc) = 55.1°. The dispersion is weak, r &gt; ν. Smamite is non-pleochroic. Electron microprobe analyses provided the empirical formula Ca2.03Sb0.97(OH)4[H1.10(As1.99Si0.01O4)2]·6H2O. Smamite is triclinic, P1–, a = 5.8207(4), b = 8.0959(6), c = 8.21296(6) Å, α = 95.8343(7)°, β = 110.762(8)°, γ = 104.012(7)°, V = 402.57(5) Å3, and Z = 1. The structure (Robs = 0.027 for 1518 I&gt;3σI reflections) is based upon {Ca2(H2O)6Sb(OH)4[H(AsO4)2]} infinite chains consisting of edge-sharing dimers of Ca(H2O)3O2(OH)2 polyhedra that share edges with Sb(OH)4O2 octahedra; adjacent chains are linked by H-bonds, including one strong, symmetrical H-bond with an O–H bond-length of ∼1.23 Å. The name “smamite” is based on the acronym of the Sainte-Marie-aux-Mines district.

Okieite, Mg3[V10O28]·28H2O, a new decavanadate mineral from the Burro mine, Slick Rock mining district, San Miguel County, Colorado, USA

ABSTRACT Okieite, Mg3[V10O28]·28H2O, is a new decavanadate mineral from the Burro mine, Slick Rock district, San Miguel County, Colorado, USA (type locality); the mineral is also found at the Hummer mine, Paradox Valley, Montrose County, also in Colorado. The mineral is rare; it occurs with dickthomssenite on montroseite- and corvusite-bearing sandstone. Crystals of okieite from the Burro mine are equant to prismatic, commonly appearing like curving columns (up to about 3 mm in length) and often exhibiting rounded faces. The streak of okieite is light orange yellow, and the luster is vitreous. The Mohs hardness is ca. 1½, the tenacity is brittle, the fracture is curved or conchoidal, there is no cleavage, and the measured density is 2.20(2) g/cm3. Okieite is biaxial (–), with α = 1.720(3), β = 1.745(3), γ = 1.765(3) (white light); 2V = 84(2)° with strong r &lt; v dispersion. The optical orientation is X ^ a = 37°, Y ^ c = 28°, Z ^ b = 31°. No pleochroism is observed in okieite. The empirical formula from electron-probe microanalysis (calculated on the basis of V = 10 and O = 56 apfu as indicated by the structure) is Mg2.86[H0.28V5+10O28]·28H2O. Okieite is triclinic, , with a 10.55660(19), b 10.7566(2), c 21.3555(15)Å, α 90.015(6), β 97.795(7), γ 104.337(7)°, and V 2326.30(19)Å3, as determined by single-crystal X-ray diffractometry. The strongest four diffraction lines in the powder diffractograms are [d in Å(I)(hkl)]: 9.71(100); 8.32(19); 11.04(17)(002); and 6.42(12)(110, . The atomic arrangement of okieite [R1 = 0.0352 for 11,327 I &gt; 2σI reflections] consists of a {V10O28}6– (decavanadate) structural unit and a {[Mg(H2O)6]3·10H2O}6+ interstitial complex. Only hydrogen bonding links the structural unit with the components of the interstitial complex. Okieite is isostructural with synthetic Mg3[V10O28]·28H2O. The name okieite is for Craig (“Okie”) Howell of Naturita, Colorado.

TEMPERATURE EFFECT ON DENSITY AND VISCOSITY OF LIGHT, MEDIUM, AND HEAVY CRUDE OILS

The density and dynamic viscosity of four light, medium, and heavy (extra-viscous) crude oil samples from Tatarstan Oil Field (Russian Federation) have been measured over the temperature range from (293 to 473) K (for density) and from (293 to 348) K (for viscosity) at atmospheric pressure (101 kPa). The density measurements were made using a new densimeter based on hydrostatic weighing method. The viscosity measurements of the same crude oil samples were made us-ing Brookfield rotational viscometer (DV-II+PRO, LVD-II+PRO). The combined expanded uncertainty of the density, viscosity, atmospheric pressure, and temperature measurements at 0.95 confidence level with a coverage factor of k = 2 is estimated to be 0.16 %, 1.0 %, 1.0 %, and 20 mK, respectively. For validation of the reliability and accuracy of the measured density data and correct operation of the new densimeter, all oil samples were measured using the pycnometric method. The present study showed that the densities measured using the new hydrostatic weighing densimeter (HWD) are agree with the values obtained with pycnometric method within (0.03 to 0.14) %. The measured density and viscosity data were used to develop widerange correlations as a function of temperature and API characteristics. The measured densities were represented using simple function of temperature (polynomial type) with API gravity dependent parameters with an accuracy of AAD within from (0.10 to 0.18) %. The measured viscosity data were also used to develop linear Arrhenius and VTF models. API gravity dependence of the Arrhenius parameters was studied.

Bicapite, KNa2Mg2(H2PV145+O42)·25H2O, a new polyoxometalate mineral with a bicapped Keggin anion from the Pickett Corral mine, Montrose County, Colorado, U.S.A.

Bicapite, KNa2Mg2(H2PV145+O42)·25H2O, is a new mineral species (IMA2018-048) discovered at the Pickett Corral mine, Montrose County, Colorado, U.S.A. Bicapite occurs as square tablets up to about 0.2 mm on edge on montroseite-corvusite-bearing sandstone. Crystals are dark red-brown, often appearing black. The streak is orange, and the luster is vitreous. Bicapite is brittle, has a Mohs hardness of 1½, and displays one excellent cleavage on {100}. The measured density is 2.44(2) g/cm3. Bicapite is uniaxial (+), ω = 1.785(5), ε ≈ 1.81 (white light); pleochroism is red-brown; E &gt; O, slight. The electron probe microanalysis and results of the crystal structure determination provided the empirical formula (based on 67 O apfu) (K1.23Na2.23Mg1.48)Σ4.94[H2.51P1.02(V13.915+Mo0.076+)Σ13.98O42]·25H2O. Bicapite is tetragonal, I4/m, with a = 11.5446(12) Å, c = 20.5460(14) Å, V = 2738.3(6) Å3, and Z = 2. The strongest four lines in the diffraction pattern are [d in Å (I) (hkl)]: 10.14 (100) (002,101); 2.978 (29) (134,206); 2.809 (11) (305); and 2.583 (11) (420,008). The atomic arrangement of bicapite was solved and refined to R1 = 0.0465 for 1008 independent reflections with I &gt; 2σI. The structural unit is a [H2PV125+O40(V5+O)2]7– heteropolyanion composed of 12 distorted VO6 octahedra surrounding a central PO4 tetrahedron and capped on opposite sides by two VO5 square pyramids; the structural unit is a modification of the α-isomer of the Keggin anion, [XM12O40]n–. Charge balance in the structure is maintained by the [KNa2Mg2(H2O)25]7+ interstitial complex. The name bicapite is in recognition of this being the only known mineral with a structure based on a bicapped Keggin anion. The discovery of bicapite and numerous other natural polyoxometalate compounds in the Colorado Plateau uranium/vanadium deposits make that the most productive region found to date for naturally occurring polyoxometalate compounds.