scholarly journals Dopamine effects on frontal cortical blood flow and motor inhibition in Parkinson's disease

Cortex ◽  
2019 ◽  
Vol 115 ◽  
pp. 99-111 ◽  
Author(s):  
Paula Trujillo ◽  
Nelleke C. van Wouwe ◽  
Ya-Chen Lin ◽  
Adam J. Stark ◽  
Kalen J. Petersen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Blood Flow ◽  
Motor Inhibition ◽  
Cortical Blood Flow

Changes in thalamic blood flow caused by subthalamic deep brain stimulation in Parkinson's disease

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S333-S333
Author(s):  
Kenichi Yamamoto ◽  
Atsushi Umemura ◽  
Kazuo Yamada
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Blood Flow ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Deep Brain

Lower vascular tone and larger plasma volume in Parkinson's disease with orthostatic hypotension

2011 ◽  
Vol 111 (2) ◽  
pp. 443-448 ◽  
Author(s):  
J. T. Groothuis ◽  
R. A. J. Esselink ◽  
J. P. H. Seeger ◽  
M. J. H. van Aalst ◽  
M. T. E. Hopman ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Blood Flow ◽  
Orthostatic Hypotension ◽  
Vascular Resistance ◽  
Plasma Volume ◽  
Venous Pressure ◽  
Dilution Method ◽  
Significant Difference ◽  
Head Up Tilt

The pathophysiology of orthostatic hypotension in Parkinson's disease (PD) is incompletely understood. The primary focus has thus far been on failure of the baroreflex, a central mediated vasoconstrictor mechanism. Here, we test the role of two other possible factors: 1) a reduced peripheral vasoconstriction (which may contribute because PD includes a generalized sympathetic denervation); and 2) an inadequate plasma volume (which may explain why plasma volume expansion can manage orthostatic hypotension in PD). We included 11 PD patients with orthostatic hypotension (PD + OH), 14 PD patients without orthostatic hypotension (PD − OH), and 15 age-matched healthy controls. Leg blood flow was examined using duplex ultrasound during 60° head-up tilt. Leg vascular resistance was calculated as the arterial-venous pressure gradient divided by blood flow. In a subset of 9 PD + OH, 9 PD − OH, and 8 controls, plasma volume was determined by indicator dilution method with radiolabeled albumin (125I-HSA). The basal leg vascular resistance was significantly lower in PD + OH (0.7 ± 0.3 mmHg·ml−1·min) compared with PD − OH (1.3 ± 0.6 mmHg·ml−1·min, P < 0.01) and controls (1.3 ± 0.5 mmHg·ml−1·min, P < 0.01). Leg vascular resistance increased significantly during 60° head-up tilt with no significant difference between the groups. Plasma volume was significantly larger in PD + OH (3,869 ± 265 ml) compared with PD − OH (3,123 ± 377 ml, P < 0.01) and controls (3,204 ± 537 ml, P < 0.01). These results indicate that PD + OH have a lower basal leg vascular resistance in combination with a larger plasma volume compared with PD − OH and controls. Despite the increase in leg vascular resistance during 60° head-up tilt, PD + OH are unable to maintain their blood pressure.

Correlated regions of cerebral blood flow with clinical parameters in Parkinson’s disease; comparison using ‘Anatomy’ and ‘Talairach Daemon’ software

2011 ◽  
Vol 26 (2) ◽  
pp. 164-174 ◽  
Author(s):  
Hyun Jin Yoon ◽  
Sang Myung Cheon ◽  
Young Jin Jeong ◽  
Do-Young Kang
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Clinical Parameters

Regional cerebral blood flow changes in Parkinson's disease: correlation with disease duration

2009 ◽  
Vol 28 (3) ◽  
pp. 114-120
Author(s):  
M. Kapitán ◽  
R. Ferrando ◽  
E. Diéguez ◽  
O. de Medina ◽  
R. Aljanati ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Disease Duration ◽  
Regional Cerebral Blood ◽  
Flow Changes

scholarly journals Correlation between regional cerebral blood flow and dementia in Parkinson's disease.

1986 ◽  
Vol 53 (1) ◽  
pp. 112-114
Author(s):  
Tokuzo Miyazaki ◽  
Akiro Terashi ◽  
Hiroyuki Tezuka ◽  
Noboru Kasahara ◽  
Isamu Koizumi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood

scholarly journals Positron Emission Tomography in Parkinson’s Disease

1992 ◽  
Vol 19 (S1) ◽  
pp. 138-141 ◽  
Author(s):  
Barry J. Snow
Keyword(s):  
Parkinson’S Disease ◽  
Positron Emission Tomography ◽  
Parkinson's Disease ◽  
Blood Flow ◽  
D2 Receptor ◽  
The Body ◽  
Emission Tomography ◽  
Motor Tasks ◽  
Positron Emission ◽  
Ligand Interactions

ABSTRACT:Positron emission tomography (PET) allows the study of physiological and neurochemical processes which would otherwise be inaccessible, using radioactive labels on biological compounds to follow their fate in the body. By analysing changes of concentration with time we can measure blood flow, neuronal metabolism and receptor ligand interactions. In Parkinson’s disease (PD), PET has been used to examine the dopaminergic deficit and its relationship to motor performance. It has also been shown to detect asymptomatic dopaminergic lesions that have implications for the etiology of PD. In untreated PD there is increased density of D2 binding sites, while in chronically treated PD with motor fluctuations, D2 receptor density is reduced. [18F]-fluorodeoxyglucose studies of demented PD patients show a pattern of cortical metabolism similar to Alzheimer’s disease. Activation studies, which measure changes in blood flow during the performance of motor tasks, show reduced activation of medial frontal areas in PD.

Sign in / Sign up

Export Citation Format

Share Document