Introduction
: Gender differences in dementia patients have been investigated extensively, however, demographic, risk, and pharmacological factors associated with gender differences in dementia patients associated with Lewy Body Dementia(LBD) and Parkinson’s disease with dementia (PDD) are not fully understood. We tested the hypothesis that specific factors may contribute to the observed gender differences in LBD and PDD patients.
Methods
: A 5‐year retrospective data analytical study was conducted using 4526 men and 3676 women collected from a regional hospital database. We performed logistic regression analysis to determine factors associated with gender differences in LBD and PDD patients. Multicollinearity and significant interactions between independent variables in the model were examined using variance inflation factors, while a Cox & Snell classification was applied to check the model fitness.
Results
: In the adjusted analysis, African‐American men (AAM) (OR = 0.249, 95% CI, 0.088‐0.703, P = 0.009) were more likely to present with PDD, while women with increasing age (OR = 1.042, 95% CI, 1.025‐1.058, P<0.002) were more likely to present with LBD. Escitalopram was associated with LBD in men (OR = 1.444, 95% CI, 1.079‐1.932, P = 0.014) and PDD in women (OR = 0.651, 95% CI, 0.468‐0.906, P = 0.011).
Conclusions
: Our findings revealed gender differences in LBD and PDD. More men presented with. PDD based on race, while women presented with LBD more based on age.