45. Quality parameters of red blood cells isolated from room temperature-stored umbilical cord blood

Cryobiology ◽  
2011 ◽  
Vol 63 (3) ◽  
pp. 318
Author(s):  
Mariia Zhurova ◽  
John Akabutu ◽  
Jason Acker
Keyword(s):  
Cord Blood ◽  
Red Blood Cells ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Room Temperature ◽  
Quality Parameters

scholarly journals Human Leukocyte Antigen and Red Blood Cells Impact Umbilical Cord Blood CD34+ Cell Viability after Thawing

2019 ◽  
Vol 20 (19) ◽  
pp. 4875 ◽  
Author(s):  
Vanegas ◽  
Galindo ◽  
Páez-Gutiérrez ◽  
González-Acero ◽  
Medina-Valderrama ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Cell Viability ◽  
Cord Blood ◽  
Red Blood Cells ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Human Leukocyte ◽  
Hla Typing ◽  
Leukocyte Antigen

Hematopoietic progenitor cell (HPC) transplantation is a treatment option for malignant and nonmalignant diseases. Umbilical cord blood (UCB) is an important HPC source, mainly for pediatric patients. It has been demonstrated that human leukocyte antigen (HLA) matching and cell dose are the most important features impacting clinical outcomes. However, UCB matching is performed using low resolution HLA typing and it has been demonstrated that the unnoticed mismatches negatively impact the transplant. Since we found differences in CD34+ viability after thawing of UCB units matched for two different patients (p = 0.05), we presumed a possible association between CD34+ cell viability and HLA. We performed a multivariate linear model (n = 67), comprising pre-cryopreservation variables and high resolution HLA genotypes separately. We found that pre-cryopreservation red blood cells (RBC), granulocytes, and viable CD34+ cell count significantly impacted CD34+ viability after thawing, along with HLA-B or -C (R2 = 0.95, p = 0.01; R2 = 0.56, p = 0.007, respectively). Although HLA-B*40:02 may have a negative impact on CD34+ cell viability, RBC depletion significantly improves it.

Potential use of autologous umbilical cord blood red blood cells for early transfusion needs of premature infants

Transfusion ◽  
2006 ◽  
Vol 46 (6) ◽  
pp. 1049-1056 ◽  
Author(s):  
Marijke Jansen ◽  
Anneke Brand ◽  
Jeannette S. von Lindern ◽  
Sicco Scherjon ◽  
Frans J. Walther
Keyword(s):  
Cord Blood ◽  
Red Blood Cells ◽  
Umbilical Cord ◽  
Premature Infants ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Potential Use

Osmotic parameters of red blood cells from umbilical cord blood

Cryobiology ◽  
2014 ◽  
Vol 68 (3) ◽  
pp. 379-388 ◽  
Author(s):  
Mariia Zhurova ◽  
Locksley E. McGann ◽  
Jason P. Acker
Keyword(s):  
Cord Blood ◽  
Red Blood Cells ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells
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