scholarly journals Novel dynamic residue network analysis approaches to study allosteric modulation: SARS-CoV-2 Mpro and its evolutionary mutations as a case study

Author(s):  
Olivier Sheik Amamuddy ◽  
Rita Afriyie Boateng ◽  
Victor Barozi ◽  
Dorothy Wavinya Nyamai ◽  
Özlem Tastan Bishop
Public Voices ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. 89
Author(s):  
Amy Probsdorfer Kelley ◽  
John C. Morris

The process to win approval to build a national memorial on the National Mall inWashington, DC is both long and complex. Many memorials are proposed, but few are chosen to inhabit the increasingly scarce space available on the Mall. Through the use of network analysis we compare and contrast two memorial proposals, with an eye toward understanding why one proposal was successful while the other seems to have failed. We conclude that the success of a specific memorial has less to do with the perceived popularity of the person or event to be memorialized, and more to do with how the sponsors use the network of people and resources available to advocate for a given proposal.


2021 ◽  
pp. 146144482110221
Author(s):  
Tamas Tofalvy ◽  
Júlia Koltai

In this article, we argue that offline inequalities, such as core–periphery relations of the music industry, are reproduced by streaming platforms. First, we offer an overview of the reproduction of inequalities and core–periphery dynamics in the music industry. Then we illustrate this through a small-scale network analysis case study of Hungarian metal bands’ connections on Spotify. We show that the primary determinant of a given band’s international connectedness in Spotify’s algorithmic ecosystem is their international label connections. Bands on international labels have more reciprocal international connections and are more likely to be recommended based on actual genre similarity. However, bands signed with local labels or self-published tend to have domestic connections and to be paired with other artists by Spotify’s recommendation system according to their country of origin.


2019 ◽  
Vol 5 (1) ◽  
pp. 444-467
Author(s):  
Katherine A. Crawford

AbstractOstia, the ancient port of Rome, had a rich religious landscape. How processional rituals further contributed to this landscape, however, has seen little consideration. This is largely due to a lack of evidence that attests to the routes taken by processional rituals. The present study aims to address existing problems in studying processions by questioning what factors motivated processional movement routes. A novel computational approach that integrates GIS, urban network analysis, and agent-based modelling is introduced. This multi-layered approach is used to question how spectators served as attractors in the creation of a processional landscape using Ostia’s Campo della Magna Mater as a case study. The analysis of these results is subsequently used to gain new insight into how a greater processional landscape was created surrounding the sanctuary of the Magna Mater.


2021 ◽  
Vol 10 (7) ◽  
pp. 491
Author(s):  
Manuel Curado ◽  
Rocio Rodriguez ◽  
Manuel Jimenez ◽  
Leandro Tortosa ◽  
Jose F. Vicent

Taking into account that accessibility is one of the most strategic and determining factors in economic models and that accessibility and tourism affect each other, we can say that the study and improvement of one of them involved the development of the other. Using network analysis, this study presents an algorithm for labeling the difficulty of the streets of a city using different accessibility parameters. We combine network structure and accessibility factors to explore the association between innovative behavior within the street network, and the relationships with the commercial activity in a city. Finally, we present a case study of the city of Avila, locating the most inaccessible areas of the city using centrality measures and analyzing the effects, in terms of accessibility, on the commerce and services of the city.


2015 ◽  
Vol 6 (1) ◽  
pp. 30-34 ◽  
Author(s):  
Iraj Mohammadfam ◽  
Susan Bastani ◽  
Mahbobeh Esaghi ◽  
Rostam Golmohamadi ◽  
Ali Saee

2014 ◽  
Vol 2 (1) ◽  
pp. 104-138 ◽  
Author(s):  
Susana Nicola ◽  
Eduarda Pinto Ferreira ◽  
João José Pinto Ferreira

The research presented in this paper proposes a novel quantitative model for decomposing and assessing the Value for the Customer. The proposed approach builds on the different dimensions of the Value Network analysis proposed by Verna Allee having as background the concept of Value for the Customer proposed by Woodall. In this context, the Value for the Customer is modelled as a relationship established between the exchanged deliverables and a combination of tangible and intangible assets projected into their endogenous or exogenous dimensions. The Value Network Analysis of the deliverables exchange enables an in-depth understanding of this frontier and the implicit modelling of co-creation scenarios. The proposed Conceptual Model for Decomposing Value for the Customer combines several concepts: from the marketing area we have the concept of Value for the Customer; from the area of intellectual capital the concept of Value Network Analysis; from the collaborative networks area we have the perspective of the enterprise life cycle and the endogenous and exogenous perspectives; at last, the proposed model is supported by a mathematical formal description that stems from the area of Multi-Criteria Decision Making. The whole concept is illustrated in the context of a case study of an enterprise in the footwear industry (Pontechem). The merits of this approach seem evident from the contact with Pontechem as it provides a structured approach for the enterprises to assess the adequacy of their value proposition to the client/customer needs and how these relate to their endogenous and/or exogenous tangible or intangible assets. The proposed model, as a tool, may therefore be a useful instrument in supporting the commercialisation of new products and/or services.


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