The role of DNA repair capacity in lung cancer risk among never-smokers: A systematic review of epidemiologic studies

Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to lung cancer risk. We conducted a meta-analysis of epidemiologic studies on the association between genetic polymorphisms in both base excision repair and nucleotide excision repair pathways, and lung cancer. We found xeroderma pigmentosum complementation group A (XPA) G23A (odds ratio (OR)=0.76, 95% confidence interval (CI)=0.61–0.94), 8-oxoguanine DNA glycosylase 1 (OGG1) Ser326Cys (OR=1.22, 95% CI=1.02–1.45), and excision repair cross-complementing group 2 (ERCC2) Lys751Gln (OR=1.27, 95% CI=1.10–1.46) polymorphisms were associated with lung cancer risk. Considering the data available, it can be conjectured that if there is any risk association between a single SNP and lung cancer, the risk fluctuation will probably be minimal. Advances in the identification of new polymorphisms and in high-throughput genotyping techniques will facilitate the analysis of multiple genes in multiple DNA repair pathways. Therefore, it is likely that the defining feature of future epidemiologic studies will be the simultaneous analysis of large samples of cases and controls.

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Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers

Carcinogenesis ◽

10.1093/carcin/bgp287 ◽

2009 ◽

Vol 31 (2) ◽

pp. 234-238 ◽

Cited By ~ 71

Author(s):

Y. Wang ◽

P. Broderick ◽

A. Matakidou ◽

T. Eisen ◽

R. S. Houlston

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Lung Cancer Risk ◽

Never Smokers

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Alcohol Drinking and Lung Cancer Risk: An Evaluation Based on a Systematic Review of Epidemiologic Evidence among the Japanese Population

Japanese Journal of Clinical Oncology ◽

10.1093/jjco/hyl146 ◽

2007 ◽

Vol 37 (3) ◽

pp. 168-174 ◽

Cited By ~ 12

Author(s):

Kenji Wakai ◽

Chisato Nagata ◽

Tetsuya Mizoue ◽

Keitaro Tanaka ◽

Yoshikazu Nishino ◽

...

Keyword(s):

Lung Cancer ◽

Systematic Review ◽

Cancer Risk ◽

Alcohol Drinking ◽

Japanese Population ◽

Lung Cancer Risk ◽

Epidemiologic Evidence

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Domestic incense use and lung cancer in Asia: a review

Reviews on Environmental Health ◽

10.1515/reveh-2015-0060 ◽

2016 ◽

Vol 31 (1) ◽

Cited By ~ 3

Author(s):

Wei Jie Seow ◽

Qing Lan

Keyword(s):

Lung Cancer ◽

Systematic Review ◽

Air Pollution ◽

Cancer Risk ◽

Lung Cancer Risk ◽

Smoking Status ◽

Case Control ◽

Negative Association ◽

Future Studies ◽

Manual Review

AbstractWhile there is strong evidence for the association between household air pollution and lung cancer among non-smoking women, the association between domestic incense use and lung cancer risk has been inconsistent. We conducted a systematic review of PubMed articles authored between 1969 and August 25, 2015 before performing a manual review of each study, and found a total of seven published studies on this topic. Most of the studies are case-control in design and did not further stratify by sex and smoking status. Of the seven studies, three reported positive associations, three reported null associations and one study found a negative association between incense use and lung cancer. Only one study reported estimates for non-smoking women. Future studies should be larger in sample size, stratify by both sex and smoking status in their analyses, and collect more detailed information on incense use in order to facilitate the understanding of the association between domestic incense use and lung cancer risk among non-smoking women in Asia.

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