scholarly journals The Cyclic Nucleotide-Gated Channel CNGC14 Regulates Root Gravitropism in Arabidopsis thaliana

2015 ◽  
Vol 25 (23) ◽  
pp. 3119-3125 ◽  
Author(s):  
Han-Wei Shih ◽  
Cody L. DePew ◽  
Nathan D. Miller ◽  
Gabriele B. Monshausen
Keyword(s):  
Arabidopsis Thaliana ◽  
Cyclic Nucleotide ◽  
Gated Channel ◽  
Root Gravitropism

scholarly journals Arabidopsis thaliana Cyclic Nucleotide Gated Channel 3 forms a non-selective ion transporter involved in germination and cation transport

2006 ◽  
Vol 57 (4) ◽  
pp. 791-800 ◽  
Author(s):  
Anthony Gobert ◽  
Graeme Park ◽  
Anna Amtmann ◽  
Dale Sanders ◽  
Frans J. M. Maathuis
Keyword(s):  
Arabidopsis Thaliana ◽  
Cyclic Nucleotide ◽  
Cation Transport ◽  
Ion Transporter ◽  
Gated Channel

scholarly journals The Complex Story of Plant Cyclic Nucleotide-Gated Channels

2021 ◽  
Vol 22 (2) ◽  
pp. 874
Author(s):  
Edwin Jarratt-Barnham ◽  
Limin Wang ◽  
Youzheng Ning ◽  
Julia M. Davies
Keyword(s):  
Arabidopsis Thaliana ◽  
Stress Response ◽  
Complex Formation ◽  
Cyclic Nucleotides ◽  
Cyclic Nucleotide ◽  
Cation Channels ◽  
Cyclic Monophosphate ◽  
Cyclic Nucleotide Gated Channels ◽  
Gated Channel

Plant cyclic nucleotide-gated channels (CNGCs) are tetrameric cation channels which may be activated by the cyclic nucleotides (cNMPs) adenosine 3′,5′-cyclic monophosphate (cAMP) and guanosine 3′,5′-cyclic monophosphate (cGMP). The genome of Arabidopsis thaliana encodes 20 CNGC subunits associated with aspects of development, stress response and immunity. Recently, it has been demonstrated that CNGC subunits form heterotetrameric complexes which behave differently from the homotetramers produced by their constituent subunits. These findings have widespread implications for future signalling research and may help explain how specificity can be achieved by CNGCs that are known to act in disparate pathways. Regulation of complex formation may involve cyclic nucleotide-gated channel-like proteins.

scholarly journals Systemic administration of ivabradine, a hyperpolarization‐activated cyclic nucleotide‐gated channel inhibitor, blocks spontaneous absence seizures

Epilepsia ◽  
2021 ◽  
Author(s):  
Yasmine Iacone ◽  
Tatiana P. Morais ◽  
François David ◽  
Francis Delicata ◽  
Joanna Sandle ◽  
...  
Keyword(s):  
Cyclic Nucleotide ◽  
Systemic Administration ◽  
Absence Seizures ◽  
Gated Channel

Expression of the olfactory cyclic nucleotide gated channel (CNG1) in the rat brain

Neuroreport ◽  
1995 ◽  
Vol 6 (10) ◽  
pp. 1459-1463 ◽  
Author(s):  
Alaa El-Din El-Husseini ◽  
Christopher Bladen ◽  
Steven R. Vincent
Keyword(s):  
Rat Brain ◽  
Cyclic Nucleotide ◽  
Gated Channel

Impaired Opsin Targeting and Cone Photoreceptor Migration in the Retina of Mice Lacking the Cyclic Nucleotide-Gated Channel CNGA3

2005 ◽  
Vol 46 (4) ◽  
pp. 1516 ◽  
Author(s):  
Stylianos Michalakis ◽  
Heidi Geiger ◽  
Silke Haverkamp ◽  
Franz Hofmann ◽  
Andrea Gerstner ◽  
...  
Keyword(s):  
Cyclic Nucleotide ◽  
Cone Photoreceptor ◽  
Gated Channel

Divalent cations block the cyclic nucleotide-gated channel of olfactory receptor neurons

1993 ◽  
Vol 69 (5) ◽  
pp. 1758-1768 ◽  
Author(s):  
F. Zufall ◽  
S. Firestein
Keyword(s):  
Cyclic Amp ◽  
Calcium Channels ◽  
Cyclic Nucleotide ◽  
Olfactory Receptor ◽  
Single Channel ◽  
Divalent Cations ◽  
Olfactory Receptor Neurons ◽  
Gated Channel ◽  
Receptor Neurons ◽  
Single Channel Currents

1. The effects of external divalent cations on odor-dependent, cyclic AMP-activated single-channel currents from olfactory receptor neurons of the tiger salamander (Ambystoma tigrinum) were studied in inside-out membrane patches taken from dendritic regions of freshly isolated sensory cells. 2. Channels were reversibly activated by 100 microM cyclic AMP. In the absence of divalent cations, the channel had a linear current-voltage relation giving a conductance of 45 pS. With increasing concentrations of either Ca2+ or Mg2+ in the external solution, the channel displayed a rapid flickering behavior. At higher concentrations of divalent cations, the transitions were too rapid to be fully resolved and appeared as a reduction in mean unitary single-channel current amplitude. 3. This effect was voltage dependent, and on analysis was shown to be due to an open channel block by divalent ions. In the case of Mg2+, the block increased steadily with hyperpolarization. In contrast, for Ca2+ the block first increased with hyperpolarization and then decreased with further hyperpolarization beyond -70 mV, providing evidence for Ca2+ permeation of this channel. 4. This block is similar to that seen in voltage-gated calcium channels. Additionally, the cyclic nucleotide-gated channel shows some pharmacological similarities with L-type calcium channels, including a novel block of the cyclic nucleotide channel by nifedipine (50 microM). 5. Our results indicate that the sensory generator current simultaneously depends on the presence of the second messenger and on the membrane potential of the olfactory neuron.

scholarly journals Age-dependent down-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 4 causes deterioration of canine sinoatrial node function

2017 ◽  
Vol 49 (5) ◽  
pp. 400-408 ◽  
Author(s):  
Jianlin Du ◽  
Songbai Deng ◽  
Di Pu ◽  
Yajie Liu ◽  
Jun Xiao ◽  
...  
Keyword(s):  
Cyclic Nucleotide ◽  
Sinoatrial Node ◽  
Down Regulation ◽  
Age Dependent ◽  
Gated Channel
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