Ursolic acid exhibits anti-inflammatory effects through blocking TLR4-MyD88 pathway mediated by autophagy

Cytokine ◽  
2019 ◽  
Vol 123 ◽  
pp. 154726 ◽  
Author(s):  
Jun Zhao ◽  
Haoyi Zheng ◽  
Zhongguo Sui ◽  
Fanbo Jing ◽  
Xianghua Quan ◽  
...  
Keyword(s):  
Ursolic Acid ◽  
Anti Inflammatory ◽  
Myd88 Pathway

Ursolic Acid and Oleanolic Acid: Pentacyclic Terpenoids with Promising Anti-Inflammatory Activities

2016 ◽  
Vol 10 (1) ◽  
pp. 21-33 ◽  
Author(s):  
Dharambir Kashyap ◽  
Ajay Sharma ◽  
Hardeep S. Tuli ◽  
Sandeep Punia ◽  
Anil K. Sharma
Keyword(s):  
Ursolic Acid ◽  
Oleanolic Acid ◽  
Anti Inflammatory

Advances in Anti-inflammatory Activity, Mechanism and Therapeutic Application of Ursolic Acid

2021 ◽  
Vol 21 ◽  
Author(s):  
Mingzhu Luan ◽  
Huiyun Wang ◽  
Jiazhen Wang ◽  
Xiaofan Zhang ◽  
Fenglan Zhao ◽  
...  
Keyword(s):  
Ursolic Acid ◽  
Inflammatory Diseases ◽  
Kidney Diseases ◽  
Inflammatory Activity ◽  
Inflammatory Factors ◽  
Inflammatory Stimuli ◽  
Bowel Diseases ◽  
Anti Inflammatory

: In vivo and in vitro studies reveal that ursolic acid (UA) is able to counteract endogenous and exogenous inflammatory stimuli, and has favorable anti-inflammatory effects. The anti-inflammatory mechanisms mainly include decreasing the release of histamine in mast cells, suppressing the activities of lipoxygenase, cyclooxygenase and phospholipase, and reducing the production of nitric oxide and reactive oxygen species, blocking the activation of signal pathway, down-regulating the expression of inflammatory factors, and inhibiting the activities of elastase and complement. These mechanisms can open up new avenues for the scientific community to develop or improve novel therapeutic approaches to tackle inflammatory diseases such as arthritis, atherosclerosis, neuroinflammation, liver diseases, kidney diseases, diabetes, dermatitis, bowel diseases, cancer. The anti-inflammatory activity, the anti-inflammatory mechanism of ursolic acid and its therapeutic applications are reviewed in this paper.

SPASMOLYTIC, ANTI-INFLAMMATORY, AND ANTIOXIDANT ACTIVITY OF SALVIA GESNERIFLORA LINDLEY

2018 ◽  
Vol 15 (4) ◽  
pp. 72
Author(s):  
Abraham Gómez-Rivera ◽  
Manasés González-Cortazar ◽  
Ammy Joana Gallegos-García ◽  
Armando Escobar-Ramos ◽  
Gabriel Flores-Franco ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Guinea Pig ◽  
Ursolic Acid ◽  
Antioxidant Potential ◽  
Guinea Pig Ileum ◽  
Chromatographic Profile ◽  
Mouse Ear ◽  
Inflammatory Edema ◽  
Anti Inflammatory

Background: Salvia gesneriflora Lindley is employed in traditional Mexican medicine for the treatment of several diseases. Materials and Methods: The chromatographic profile of three extracts (SgH, SgD and SgM) of this plant allowed the identification of 11 components in SgH, the presence of rosmarinic (1), chlorogenic (2) and caffeic (3) acids and quercetin glucoside (4) in SgM and of ursolic acid (5) in SgD. The spasmolytic (electrically induced contractions of guinea-pig ileum), anti-inflammatory (edema in mouse ear) and antioxidant potential (DPPH, ABTS and FRAP assays) of the extracts were evaluated. Results: SgM showed the highest percentage of relaxation (80.67 ± 1.633%) with no significant difference (p

Group IIA Secretory PLA2 Inhibition by Ursolic Acid: A Potent Anti-Inflammatory Molecule

2007 ◽  
Vol 7 (8) ◽  
pp. 801-809 ◽  
Author(s):  
A. Nataraj ◽  
C. Raghavendra Gowda ◽  
R. Rajesh ◽  
B. Vishwanath
Keyword(s):  
Ursolic Acid ◽  
Inflammatory Molecule ◽  
Anti Inflammatory

Design and optimization of oleanolic/ursolic acid-loaded nanoplatforms for ocular anti-inflammatory applications

2015 ◽  
Vol 11 (3) ◽  
pp. 521-530 ◽  
Author(s):  
Helen L. Alvarado ◽  
Guadalupe Abrego ◽  
María L. Garduño-Ramirez ◽  
Beatriz Clares ◽  
Ana C. Calpena ◽  
...  
Keyword(s):  
Ursolic Acid ◽  
Design And Optimization ◽  
Anti Inflammatory

Anti-inflammatory effects of ursolic acid-3-acetate on human synovial fibroblasts and a murine model of rheumatoid arthritis

2017 ◽  
Vol 49 ◽  
pp. 118-125 ◽  
Author(s):  
Jong Yeong Lee ◽  
Jin Kyeong Choi ◽  
Na-Hee Jeong ◽  
Jeongsoo Yoo ◽  
Yeong Su Ha ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Ursolic Acid ◽  
Murine Model ◽  
Synovial Fibroblasts ◽  
Anti Inflammatory
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