IL-6 family cytokines in respiratory health and disease

Cytokine ◽  
2021 ◽  
pp. 155520
Author(s):  
Ruby E. Dawson ◽  
Brendan J. Jenkins ◽  
Mohamed I. Saad
Keyword(s):  
Respiratory Health ◽  
Health And Disease

scholarly journals The role of whey acidic protein four-disulfide-core proteins in respiratory health and disease

2017 ◽  
Vol 398 (4) ◽  
pp. 425-440 ◽  
Author(s):  
Donna M. Small ◽  
Declan F. Doherty ◽  
Caoifa M. Dougan ◽  
Sinéad Weldon ◽  
Clifford C. Taggart
Keyword(s):  
Protein Function ◽  
Respiratory Health ◽  
Whey Acidic Protein ◽  
Acidic Protein ◽  
Current Evidence ◽  
Core Proteins ◽  
Health And Disease ◽  
Low Molecular Weight Proteins ◽  
Potential Therapeutics

Abstract Members of the whey acidic protein (WAP) or WAP four-disulfide-core (WFDC) family of proteins are a relatively under-explored family of low molecular weight proteins. The two most prominent WFDC proteins, secretory leukocyte protease inhibitor (SLPI) and elafin (or the precursor, trappin-2), have been shown to possess multiple functions including anti-protease, anti-bacterial, anti-viral and anti-inflammatory properties. It is therefore of no surprise that both SLPI and elafin/trappin-2 have been developed as potential therapeutics. Given the abundance of SLPI and elafin/trappin-2 in the human lung, most work in the area of WFDC research has focused on the role of WFDC proteins in protecting the lung from proteolytic attack. In this review, we will outline the current evidence regarding the expanding role of WFDC protein function with a focus on WFDC activity in lung disease as well as emerging data regarding the function of some of the more recently described WFDC proteins.

scholarly journals Wearable technology: role in respiratory health and disease

Breathe ◽  
2017 ◽  
Vol 13 (2) ◽  
pp. e27-e36 ◽  
Author(s):  
Andrea Aliverti
Keyword(s):  
Respiratory Health ◽  
Pulmonary Ventilation ◽  
Data Repositories ◽  
Cloud Data ◽  
Biomedical Sensors ◽  
Air Quality Assessment ◽  
The Future ◽  
Health And Disease ◽  
Areas Of Interest ◽  
Smart Wearable

In the future, diagnostic devices will be able to monitor a patient’s physiological or biochemical parameters continuously, under natural physiological conditions and in any environment through wearable biomedical sensors. Together with apps that capture and interpret data, and integrated enterprise and cloud data repositories, the networks of wearable devices and body area networks will constitute the healthcare’s Internet of Things. In this review, four main areas of interest for respiratory healthcare are described: pulse oximetry, pulmonary ventilation, activity tracking and air quality assessment. Although several issues still need to be solved, smart wearable technologies will provide unique opportunities for the future or personalised respiratory medicine.

scholarly journals Respiratory health and disease in Europe: the new European Lung White Book

2013 ◽  
Vol 42 (3) ◽  
pp. 559-563 ◽  
Author(s):  
G. John Gibson ◽  
Robert Loddenkemper ◽  
Bo Lundbäck ◽  
Yves Sibille
Keyword(s):  
Respiratory Health ◽  
White Book ◽  
Health And Disease

scholarly journals The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?

2021 ◽  
Vol 18 (23) ◽  
pp. 12684
Author(s):  
Juan Pablo López-Cervantes ◽  
Marianne Lønnebotn ◽  
Nils Oskar Jogi ◽  
Lucia Calciano ◽  
Ingrid Nordeide Kuiper ◽  
...  
Keyword(s):  
Lung Diseases ◽  
Current Knowledge ◽  
Respiratory Health ◽  
Environmental Exposures ◽  
Multiple Exposures ◽  
Biological Responses ◽  
Technological Advances ◽  
Human Reproductive ◽  
Health And Disease ◽  
External Exposures

Emerging research suggests environmental exposures before conception may adversely affect allergies and lung diseases in future generations. Most studies are limited as they have focused on single exposures, not considering that these diseases have a multifactorial origin in which environmental and lifestyle factors are likely to interact. Traditional exposure assessment methods fail to capture the interactions among environmental exposures and their impact on fundamental biological processes, as well as individual and temporal factors. A valid estimation of exposure preconception is difficult since the human reproductive cycle spans decades and the access to germ cells is limited. The exposome is defined as the cumulative measure of external exposures on an organism (external exposome), and the associated biological responses (endogenous exposome) throughout the lifespan, from conception and onwards. An exposome approach implies a targeted or agnostic analysis of the concurrent and temporal multiple exposures, and may, together with recent technological advances, improve the assessment of the environmental contributors to health and disease. This review describes the current knowledge on preconception environmental exposures as related to respiratory health outcomes in offspring. We discuss the usefulness and feasibility of using an exposome approach in this research, advocating for the preconception exposure window to become included in the exposome concept.

scholarly journals Respiratory health and disease in a UK population-based cohort of 85 year olds: The Newcastle 85+ Study

Thorax ◽  
2016 ◽  
Vol 71 (3) ◽  
pp. 255-266 ◽  
Author(s):  
Andrew J Fisher ◽  
Mohammad E Yadegarfar ◽  
Joanna Collerton ◽  
Therese Small ◽  
Thomas B L Kirkwood ◽  
...  
Keyword(s):  
Respiratory Health ◽  
Population Based ◽  
Health And Disease

Psychological Implications of Respiratory Health and Disease

Respiration ◽  
2005 ◽  
Vol 72 (2) ◽  
pp. 210-215 ◽  
Author(s):  
Alfredo Chetta ◽  
Antonio Foresi ◽  
Emilio Marangio ◽  
Dario Olivieri
Keyword(s):  
Respiratory Health ◽  
Health And Disease

Early lung development: lifelong effect on respiratory health and disease

2013 ◽  
Vol 1 (9) ◽  
pp. 728-742 ◽  
Author(s):  
Janet Stocks ◽  
Alison Hislop ◽  
Samatha Sonnappa
Keyword(s):  
Lung Development ◽  
Respiratory Health ◽  
Health And Disease

scholarly journals Oral Prevotella Species and Their Connection to Events of Clinical Relevance in Gastrointestinal and Respiratory Tracts

2022 ◽  
Vol 12 ◽  
Author(s):  
Eija Könönen ◽  
Ulvi K. Gursoy
Keyword(s):  
Clinical Relevance ◽  
Respiratory Health ◽  
Oral Microbiome ◽  
The Core ◽  
Prevotella Nigrescens ◽  
Prevotella Melaninogenica ◽  
Mucosal Surfaces ◽  
Health And Disease ◽  
Prevotella Species ◽  
Lower Airways

Prevotella is recognized as one of the core anaerobic genera in the oral microbiome. In addition, members of this genus belong to microbial communities of the gastrointestinal and respiratory tracts. Several novel Prevotella species, most of them of oral origin, have been described, but limited knowledge is still available of their clinical relevance. Prevotella melaninogenica is among the anaerobic commensals on oral mucosae from early months of life onward, and other early colonizing Prevotella species in the oral cavity include Prevotella nigrescens and Prevotella pallens. Oral Prevotella species get constant access to the gastrointestinal tract via saliva swallowing and to lower airways via microaspiration. At these extra-oral sites, they play a role as commensals but also as potentially harmful agents on mucosal surfaces. The aim of this narrative review is to give an updated overview on the involvement of oral Prevotella species in gastrointestinal and respiratory health and disease.

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