The effects of CCL3, CCL4, CCL19 and CCL21 as molecular adjuvants on the immune response to VAA DNA vaccine in flounder (Paralichthys olivaceus)

2020 ◽  
Vol 103 ◽  
pp. 103492 ◽  
Author(s):  
Hongsen Xu ◽  
Jing Xing ◽  
Xiaoqian Tang ◽  
Xiuzhen Sheng ◽  
Wenbin Zhan
2021 ◽  
Vol 113 ◽  
pp. 185-195
Author(s):  
Tasok Leya ◽  
Irshad Ahmad ◽  
Rajendran Kooloth Valappil ◽  
Pani Prasad Kurcheti ◽  
Gayatri Tripathi ◽  
...  

2015 ◽  
Vol 81 (2) ◽  
pp. 205-217 ◽  
Author(s):  
Takashi Aoki ◽  
Tomokazu Takano ◽  
Jun-ichi Hikima

Author(s):  
L. M. Kravchenko ◽  
K. V. Kudzin ◽  
U. A. Prakulevich

The porcine reproductive and respiratory syndrome (PRRS) caused the serious economic damage to swine breeding around the world. It is a viral infective disease against which live attenuated and inactivated vaccines are not always successful. Development of new types of drugs such as DNA vaccines is necessary for improving the protection against the virus. DNA vaccines induce the development of both a cellular and humoral immune response. Such vaccines consist of a plasmid or viral vector with genes of potentially immunogenic proteins. The expression of these genes realized in cells of the vaccinated animal. It leads to the synthesis of antigen proteins triggering the immune response. The purpose of this work is to create a genetic construction that can be used as DNA vaccine against PRRS virus. The construction consists of the commercial vector pVAX1 and open reading frame of two structural proteins of PRRS virus, a lysosomal localization signal sequence of the invariant chain gene and regulatory elements necessary for the expression of cloned genes in mammalian cells.


Biomaterials ◽  
2014 ◽  
Vol 35 (1) ◽  
pp. 466-478 ◽  
Author(s):  
Jin Wang ◽  
Rongrong Zhu ◽  
Bo Gao ◽  
Bin Wu ◽  
Kun Li ◽  
...  

2006 ◽  
Vol 177 (10) ◽  
pp. 7462-7471 ◽  
Author(s):  
Stefania Capone ◽  
Immacolata Zampaglione ◽  
Alessandra Vitelli ◽  
Monica Pezzanera ◽  
Lisa Kierstead ◽  
...  

Vaccine ◽  
2001 ◽  
Vol 19 (28-29) ◽  
pp. 4053-4060 ◽  
Author(s):  
Jean-Pierre Y. Scheerlinck ◽  
Gerard Casey ◽  
Peter McWaters ◽  
Julie Kelly ◽  
David Woollard ◽  
...  

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