scholarly journals Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair

2013 ◽  
Vol 25 (2) ◽  
pp. 169-181 ◽  
Author(s):  
Yiqin Xiong ◽  
Wei Li ◽  
Ching Shang ◽  
Richard M. Chen ◽  
Pei Han ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Tissue Regeneration ◽  
Positive Feedback ◽  
Feedback Circuit ◽  
Positive Feedback Circuit

scholarly journals LncRNA MIR17HG promotes colorectal cancer liver metastasis by mediating a glycolysis-associated positive feedback circuit

Oncogene ◽  
2021 ◽  
Author(s):  
Senlin Zhao ◽  
Bingjie Guan ◽  
Yushuai Mi ◽  
Debing Shi ◽  
Ping Wei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Metastatic Tumor ◽  
Feedback Circuit ◽  
Colorectal Cancer Liver Metastasis ◽  
Positive Feedback Circuit

AbstractGlycolysis plays a crucial role in reprogramming the metastatic tumor microenvironment. A series of lncRNAs have been identified to function as oncogenic molecules by regulating glycolysis. However, the roles of glycolysis-related lncRNAs in regulating colorectal cancer liver metastasis (CRLM) remain poorly understood. In the present study, the expression of the glycolysis-related lncRNA MIR17HG gradually increased from adjacent normal to CRC to the paired liver metastatic tissues, and high MIR17HG expression predicted poor survival, especially in patients with liver metastasis. Functionally, MIR17HG promoted glycolysis in CRC cells and enhanced their invasion and liver metastasis in vitro and in vivo. Mechanistically, MIR17HG functioned as a ceRNA to regulate HK1 expression by sponging miR-138-5p, resulting in glycolysis in CRC cells and leading to their invasion and liver metastasis. More interestingly, lactate accumulated via glycolysis activated the p38/Elk-1 signaling pathway to promote the transcriptional expression of MIR17HG in CRC cells, forming a positive feedback loop, which eventually resulted in persistent glycolysis and the invasion and liver metastasis of CRC cells. In conclusion, the present study indicates that the lactate-responsive lncRNA MIR17HG, acting as a ceRNA, promotes CRLM through a glycolysis-mediated positive feedback circuit and might be a novel biomarker and therapeutic target for CRLM.

microRNA-93-5p promotes hepatocellular carcinoma progression via a microRNA-93-5p/MAP3K2/c-Jun positive feedback circuit

Oncogene ◽  
2020 ◽  
Vol 39 (35) ◽  
pp. 5768-5781
Author(s):  
Xuan Shi ◽  
Tao-Tao Liu ◽  
Xiang-Nan Yu ◽  
Asha Balakrishnan ◽  
Hai-Rong Zhu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Positive Feedback ◽  
Feedback Circuit ◽  
Positive Feedback Circuit

MicroRNA-132 and microRNA-223 control positive feedback circuit by regulating FOXO3a in inflammatory bowel disease

2016 ◽  
Vol 31 (10) ◽  
pp. 1727-1735 ◽  
Author(s):  
Hye-Youn Kim ◽  
Hyeok Yi Kwon ◽  
Huyen Trang Ha Thi ◽  
Ho Jae Lee ◽  
Gwang Il Kim ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Positive Feedback ◽  
Bowel Disease ◽  
Feedback Circuit ◽  
Positive Feedback Circuit ◽  
Inflammatory Bowel

scholarly journals GATA Factor-Dependent Positive-Feedback Circuit in Acute Myeloid Leukemia Cells

Cell Reports ◽  
2016 ◽  
Vol 16 (9) ◽  
pp. 2428-2441 ◽  
Author(s):  
Koichi R. Katsumura ◽  
Irene M. Ong ◽  
Andrew W. DeVilbiss ◽  
Rajendran Sanalkumar ◽  
Emery H. Bresnick
Keyword(s):  
Acute Myeloid Leukemia ◽  
Positive Feedback ◽  
Myeloid Leukemia ◽  
Leukemia Cells ◽  
Feedback Circuit ◽  
Gata Factor ◽  
Positive Feedback Circuit ◽  
Acute Myeloid Leukemia Cells ◽  
Acute Myeloid

scholarly journals A positive feedback circuit for ROP-mediated polar growth

2020 ◽  
Author(s):  
En Li ◽  
Yu-Ling Zhang ◽  
Xuelian Shi ◽  
Han Li ◽  
Xuefeng Yuan ◽  
...  
Keyword(s):  
Positive Feedback ◽  
Polar Growth ◽  
Feedback Circuit ◽  
Positive Feedback Circuit

scholarly journals Transcriptional effects of a positive feedback circuit in Drosophila melanogaster

BMC Genomics ◽  
2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Jarosław Bryk ◽  
R. Guy Reeves ◽  
Floyd A. Reed ◽  
Jai A. Denton
Keyword(s):  
Drosophila Melanogaster ◽  
Positive Feedback ◽  
Feedback Circuit ◽  
Positive Feedback Circuit

scholarly journals Time Delays in a Genetic Positive-Feedback Circuit

2020 ◽  
Vol 4 (1) ◽  
pp. 163-168 ◽  
Author(s):  
Alessandro Borri ◽  
Pasquale Palumbo ◽  
Abhyudai Singh
Keyword(s):  
Positive Feedback ◽  
Time Delays ◽  
Feedback Circuit ◽  
Positive Feedback Circuit
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