Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1

2021 ◽  
Author(s):  
Mengnan Zhu ◽  
Fukang Teng ◽  
Na Li ◽  
Li Zhang ◽  
Shuxian Zhang ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Amino Acid ◽  
Chain Fatty Acid ◽  
Branched Chain ◽  
Amino Acid Sensing

scholarly journals Monomethyl branched-chain fatty acid mediates amino acid sensing by mTORC1

2020 ◽  
Author(s):  
Mengnan Zhu ◽  
Fukang Teng ◽  
Na Li ◽  
Li Zhang ◽  
Jing Shao ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Amino Acid ◽  
Protein Translation ◽  
Postembryonic Development ◽  
Chain Fatty Acid ◽  
Nutrient Sensing ◽  
Acid Deficiency ◽  
Branched Chain ◽  
Amino Acid Sensing ◽  
The Impact

AbstractAnimals have developed various nutrient-sensing mechanisms for survival under fluctuating environments. Although extensive cultured cell-based analyses have discovered diverse mediators of amino acid sensing by mTOR, studies using animal models to illustrate intestine-initiated amino acid sensing mechanisms under specific physiological conditions are lacking. Here we developed a Caenorhabditis elegans model to examine the impact of amino acid deficiency on development. We discovered a leucine-derived monomethyl branched-chain fatty acid, and downstream glycosphingolipid, that critically mediate overall amino acid sensing by intestinal and neuronal mTORC1 that, in turn, regulates postembryonic development partly by controlling protein translation and ribosomal biogenesis. Additional data suggest that a similar mechanism may be conserved in mammals. This study uncovers an unexpected amino acid sensing mechanism mediated by a lipid biosynthesis pathway.

scholarly journals Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1

2021 ◽  
Vol 56 (22) ◽  
pp. 3171
Author(s):  
Mengnan Zhu ◽  
Fukang Teng ◽  
Na Li ◽  
Li Zhang ◽  
Shuxian Zhang ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Amino Acid ◽  
Chain Fatty Acid ◽  
Branched Chain ◽  
Amino Acid Sensing

scholarly journals Mitochondrial and peroxisomal beta oxidation of the branched chain fatty acid 2-methylpalmitate in rat liver.

1991 ◽  
Vol 266 (36) ◽  
pp. 24670-24675 ◽  
Author(s):  
G. Vanhove ◽  
P.P. Van Veldhoven ◽  
F. Vanhoutte ◽  
G. Parmentier ◽  
H.J. Eyssen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Rat Liver ◽  
Chain Fatty Acid ◽  
Beta Oxidation ◽  
Branched Chain

scholarly journals Branched-chain fatty acid composition of human milk and the impact of maternal diet: the Global Exploration of Human Milk (GEHM) Study

2016 ◽  
Vol 105 (1) ◽  
pp. 177-184 ◽  
Author(s):  
Kelly A Dingess ◽  
Christina J Valentine ◽  
Nicholas J Ollberding ◽  
Barbara S Davidson ◽  
Jessica G Woo ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Human Milk ◽  
Acid Composition ◽  
Maternal Diet ◽  
Chain Fatty Acid ◽  
Branched Chain ◽  
The Impact
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