Severe leucopenia associated with Sitagliptin use

Methrazone, a non-steroidal anti-inflammatory drug, was used on a monitored release study in general practice to treat 2,693 patients with rheumatoid or osteoarthritis. In a dose of 200 mg three times daily, it appeared to produce clear benefit in between 50% and 60% of patients. Adverse reactions such as dyspepsia and skin rash led to the drug being withdrawn in 11% of patients. There were three major adverse reactions possibly due to the drug (haematemesis, rectal bleeding and acute purpura), but no cases of severe leucopenia or thrombocytopenia. Methrazone is a useful anti-inflammatory agent. In particular, it is unlikely to cause interactions with other drugs, including cardiac glycosides such as digoxin.

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INFLAMMATORY REACTIONS IN RABBITS WITH A SEVERE LEUCOPENIA

Journal of Experimental Medicine ◽

10.1084/jem.22.2.174 ◽

1915 ◽

Vol 22 (2) ◽

pp. 174-193 ◽

Cited By ~ 17

Author(s):

W. E. Camp ◽

E. A. Baumgartner

Keyword(s):

Blood Vessels ◽

Inflammatory Reactions ◽

Severe Leucopenia

Congestion of blood vessels and marked edema may occur in rabbits with a severe leucopenia. These two phenomena are, therefore, independent of the leucocytes.

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Role of Hematotoxicity and Sex in Patients With Hodgkin's Lymphoma: An Analysis From the German Hodgkin Study Group

Journal of Clinical Oncology ◽

10.1200/jco.2005.205.60 ◽

2005 ◽

Vol 23 (31) ◽

pp. 8003-8011 ◽

Cited By ~ 40

Author(s):

Beate Klimm ◽

Thorsten Reineke ◽

Heinz Haverkamp ◽

Karolin Behringer ◽

Hans T. Eich ◽

...

Keyword(s):

Hodgkin’S Lymphoma ◽

Protective Role ◽

Hodgkin's Lymphoma ◽

Study Group ◽

Similar Response ◽

Who Grade ◽

Female Patients ◽

German Hodgkin Study Group ◽

Severe Leucopenia

Purpose Several scores have described sex as a prognostic factor in patients with Hodgkin's lymphoma (HL). However, little is known how sex-specific factors influence treatment outcome. We systematically investigated sex differences with regard to pretreatment characteristics and therapy-related variables, and examined their influence on the outcome of HL patients. Patients and Methods This analysis comprises 4,626 HL patients of all prognostic risk groups who were enrolled onto the multicenter studies HD4 to HD9 of the German Hodgkin Study Group. At 5.5 years, 2,050 female and 2,576 male patients were analyzed. Results Male and female patients had similar prognostic factors. There was more acute chemotherapy-related hematotoxicity in women, especially more severe leucopenia (WHO grade 3/4, 69.9% female and 55.2% male; P < .0001). Importantly, this did not translate into more infections. Female patients had similar response rates but fewer relapses and deaths, leading to a significantly better freedom from treatment failure (FFTF; at 66 months, 81% female [95% CI, 79% to 82%] and 74% male [95% CI, 72% to 76%]). Severe leucopenia during chemotherapy was strongly associated with better FFTF, both for males and females. In addition, when only those patients who developed severe leucopenia within the first two cycles of chemotherapy were included, the factor maintained its protective role. Conclusion The protective role of severe leucopenia suggests the testing of a more individualized therapy. In future trials, this therapy may be tailored in a response-adapted manner depending on the individual toxicity profile within the first cycles.

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THE BLOOD IN HOG CHOLERA

Journal of Experimental Medicine ◽

10.1084/jem.50.6.719 ◽

1929 ◽

Vol 50 (6) ◽

pp. 719-737 ◽

Cited By ~ 3

Author(s):

Paul A. Lewis ◽

Richard E. Shope

Keyword(s):

Leucocyte Count ◽

Sodium Citrate ◽

Swine Influenza ◽

Potassium Oxalate ◽

Hog Cholera ◽

Formed Element ◽

Virus Culture ◽

Severe Leucopenia ◽

Progressive Anemia

1. Prolonged and systematic examination of blood from swine with hog cholera has failed to reveal any formed element that could be identified with the etiological virus. Culture has likewise been unsuccessful. 2. The quantitative blood changes in hog cholera consist in a slowly progressive anemia, usually moderate in degree, and a rapidly progressive severe leucopenia affecting cells of the polymorphonuclear series most markedly but also including those of the lymphocytic series. 3. Incubation of hog cholera blood results in a further progress of the leucopenia, in vitro, if heparin has been used as the anticoagulant, but there is no significant change if potassium oxalate or sodium citrate has been used. 4. Consideration of the leucocytic reactions prevailing in experimental infection with B. suisepticus, in infectious enteritis, in swine influenza, following successful immunization against hog cholera, and following infection of cholera-sick swine with secondary invaders indicates that the leucocyte count would be of aid in the differential diagnosis of hog cholera.

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Severe leucopenia due to a PBFD infection in young parrots

Veterinary Quarterly ◽

10.1080/01652176.1996.9694694 ◽

1996 ◽

Vol 18 (sup1) ◽

pp. 68-68

Author(s):

N.J. Schoemaker

Keyword(s):

Severe Leucopenia

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Severe leucopenia during treatment of visceral leishmaniasis

Transactions of the Royal Society of Tropical Medicine and Hygiene ◽

10.1016/0035-9203(88)90143-5 ◽

1988 ◽

Vol 82 (3) ◽

pp. 417 ◽

Cited By ~ 1

Author(s):

G. Hiçsönmez ◽

H. Jama ◽

S. Özsoylu

Keyword(s):

Visceral Leishmaniasis ◽

Severe Leucopenia

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Leucopenia during Treatment Is a Good Prognostic Risk Factor for Patients Undergoing Chemotherapy for Hodgkin’s Lymphoma: An Analysis of the German Hodgkin Study Group (GHSG).

Blood ◽

10.1182/blood.v106.11.2674.2674 ◽

2005 ◽

Vol 106 (11) ◽

pp. 2674-2674

Author(s):

Beate Klimm ◽

Thorsten Reineke ◽

Heinz Haverkamp ◽

Hans T. Eich ◽

Karolin Behringer ◽

...

Keyword(s):

Protective Role ◽

Hodgkin's Lymphoma ◽

Who Grade ◽

Male And Female ◽

Female Patients ◽

Male Patients ◽

Severe Leucopenia ◽

Who Grade Iii ◽

Grade Iii

Abstract Purpose: A systematic analysis of gender-specific factors in Hodgkin’s lymphoma (HL) studies previously revealed a better outcome for female HL patients. Factors contributing to better prognosis among female patients not only included more favorable risk factors at diagnosis, but also more treatment-induced severe leuopenia (WHO grade III/IV). The purpose of the current analysis was to characterize and investigate the protective role of severe leucopenia for both, male and female HL patients. Patients and Methods: 4626 HL patients including 2050 females (f) and 2576 males (m) of all prognostic risk groups who were enrolled into the multicenter studies HD4-HD9 of the GHSG were evaluated. The median follow-up after treatment was 5.5 years. Results: Female patients had a significantly better freedom from treatment failure (FFTF) with 81% at 66 months (95% confidence interval 79% – 82%), when compared with male patients (74%; 72% – 76%; p<.0001). This was in part related to the occurrence of more acute chemotherapy-related leucopenia (WHO grade III/IV): 69.9% in female patients and 55.2% in male patients (p<.0001). Furthermore, severe leucopenia during chemotherapy was strongly associated with better FFTF for both, male and female patients. Separate multivariate analyses showed that severe leucopenia remained significant when only male patients were included (0.011). In addition, patients who developed severe leucopenia within the first two cycles of chemotherapy also had a significantly better FFTF (p=.0002) compared with all other patients (Klimm et al, JCO in press). When considering patients with advanced HL undergoing BEACOPP in baseline or escalated dose, the presence of severe leucopenia during chemotherapy (p=.0074) was associated with a better outcome. This finding was also confirmed when only the first two cycles of treatment were analyzed (p =.0205). Conclusion: The protective role of severe leucopenia suggests evaluating of a more individualized therapy in future trials, that may be tailored in a response-adapted manner depending on the individual toxicity profile within the first cycles.

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