A randomised controlled trial of high dose vitamin D in recent-onset type 2 diabetes

2014 ◽  
Vol 106 (3) ◽  
pp. 576-582 ◽  
Author(s):  
Shirley Elkassaby ◽  
Leonard C. Harrison ◽  
Namita Mazzitelli ◽  
John M. Wentworth ◽  
Peter G. Colman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
High Dose ◽  
Recent Onset ◽  
Onset Type ◽  
Randomised Controlled ◽  
High Dose Vitamin

scholarly journals P.64 Active Vitamin D Treatment Does Not Improve Arterial Stiffness and Markers of Cardio-Renal Risk in Patients with Type 2 Diabetes and Stage 3 Chronic Kidney Disease: a Randomised Controlled Trial

2020 ◽  
Vol 26 (Supplement 1) ◽  
pp. S88
Author(s):  
Nikolaos Fountoulakis ◽  
Salma Ayis ◽  
Anastasios Mangelis ◽  
Angeliki Panagiotou ◽  
Maria Flaquer ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Randomised Controlled Trial ◽  
Kidney Disease ◽  
Arterial Stiffness ◽  
Controlled Trial ◽  
Active Vitamin ◽  
Randomised Controlled

scholarly journals High-dose vitamin D supplementation to prevent prostate cancer progression in localised cases with low-to-intermediate risk of progression on active surveillance (ProsD): protocol of a phase II randomised controlled trial

BMJ Open ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. e044055
Author(s):  
Visalini Nair-Shalliker ◽  
David P Smith ◽  
Val Gebski ◽  
Manish I Patel ◽  
Mark Frydenberg ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
Intermediate Risk ◽  
Risk Of Progression ◽  
Randomised Controlled ◽  
High Dose Vitamin

IntroductionActive surveillance (AS) for patients with prostate cancer (PC) with low risk of PC death is an alternative to radical treatment. A major drawback of AS is the uncertainty whether a patient truly has low risk PC based on biopsy alone. Multiparametric MRI scan together with biopsy, appears useful in separating patients who need curative therapy from those for whom AS may be safe. Two small clinical trials have shown short-term high-dose vitamin D supplementation may prevent PC progression. There is no substantial evidence for its long-term safety and efficacy, hence its use in the care of men with PC on AS needs assessment. This protocol describes the ProsD clinical trial which aims to determine if oral high-dose vitamin D supplementation taken monthly for 2 years can prevent PC progression in cases with low-to-intermediate risk of progression.Method and analysisThis is an Australian national multicentre, 2:1 double-blinded placebo-controlled phase II randomised controlled trial of monthly oral high-dose vitamin D supplementation (50 000 IU cholecalciferol), in men diagnosed with localised PC who have low-to-intermediate risk of disease progression and are being managed by AS. This trial will assess the feasibility, efficacy and safety of supplementing men with an initial oral loading dose of 500 000 IU cholecalciferol, followed by a monthly oral dose of 50 000 IU during the 24 months of AS. The primary trial outcome is the commencement of active therapy for clinical or non-clinical reason, within 2 years of AS.Ethics and disseminationThis trial is approved by Bellberry Ethics Committee (2016-06-459). All results will be reported in peer-reviewed journals.Trial registration numberACTRN12616001707459.

scholarly journals A randomised controlled trial evaluating the impact of targeted vitamin D supplementation on endothelial function in type 2 diabetes mellitus: The DIMENSION trial

2016 ◽  
Vol 13 (3) ◽  
pp. 192-200 ◽  
Author(s):  
Rinkoo Dalan ◽  
Huiling Liew ◽  
Pryseley Nkouibert Assam ◽  
Edwin SY Chan ◽  
Fahad Javaid Siddiqui ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Randomised Controlled ◽  
The Impact

scholarly journals Bedtime ingestion of hypertension medications reduces the risk of new-onset type 2 diabetes: a randomised controlled trial

Diabetologia ◽  
2015 ◽  
Vol 59 (2) ◽  
pp. 255-265 ◽  
Author(s):  
Ramón C. Hermida ◽  
Diana E. Ayala ◽  
Artemio Mojón ◽  
José R. Fernández
Keyword(s):  
Type 2 Diabetes ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Onset Type ◽  
Randomised Controlled ◽  
New Onset

Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial

The Lancet ◽  
2010 ◽  
Vol 376 (9752) ◽  
pp. 1543-1551 ◽  
Author(s):  
Dick de Zeeuw ◽  
Rajiv Agarwal ◽  
Michael Amdahl ◽  
Paul Audhya ◽  
Daniel Coyne ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Randomised Controlled Trial ◽  
Vitamin D Receptor ◽  
Controlled Trial ◽  
Receptor Activation ◽  
Randomised Controlled
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