In vitro inhibitory effects of major bioactive constituents of Andrographis paniculata, Curcuma longa and Silybum marianum on human liver microsomal morphine glucuronidation: A prediction of potential herb-drug interactions arising from andrographolide, curcumin and silybin inhibition in humans

2018 ◽  
Vol 33 (1) ◽  
pp. 67-76 ◽  
Author(s):  
Verawan Uchaipichat
Keyword(s):  
Drug Interactions ◽  
Human Liver ◽  
Curcuma Longa ◽  
Andrographis Paniculata ◽  
Inhibitory Effects ◽  
Silybum Marianum ◽  
Bioactive Constituents

scholarly journals Curcumin augments cytostatic and anti-invasive effects of mitoxantrone on carcinosar-coma cells in vitro

2016 ◽  
Vol 63 (3) ◽  
Author(s):  
Marcin Luty ◽  
Edyta Kwiecień ◽  
Magdalena Firlej ◽  
Anna Łabędź-Masłowska ◽  
Milena Paw ◽  
...  
Keyword(s):  
Curcuma Longa ◽  
Drug Resistant ◽  
Additive Effects ◽  
Inhibitory Effects ◽  
Curcumin Treatment ◽  
Invasive Potential ◽  
Effective Doses ◽  
Walker 256

Numerous adverse effects limit the applicability of mitoxantrone for the treatment of drug-resistant tumors, including carcinosarcoma. Here, we estimated the additive effects of mitoxantrone and curcumin, a plant-derived biomolecule isolated from Curcuma longa, on the neoplastic and invasive potential of carcinosarcoma cells in vitro. Curcumin augmented cytostatic, cytotoxic and anti-invasive effects of mitoxantrone on Walker-256 cells. It also strengthened inhibitory effects of mitoxantrone on the motility of drug-resistant Walker-256 cells that had retained the viability after long-term mitoxantrone/curcumin treatment. Thus, curcumin reduces the effective doses of mitoxantrone and augments its interference with the invasive potential of drug-resistant carcinosarcoma cells.

Peptides isolated from human liver with specific inhibitory effects on reassociation/reactivation of in vitro dissociated lactic dehydrogenase (LDH-M4 and −H4) isozymes

1980 ◽  
Vol 1 (3) ◽  
pp. 223-244 ◽  
Author(s):  
Guido A. Schoenenberger ◽  
Susanne Buser ◽  
Lorenz Cueni ◽  
Heinz Döbeli ◽  
Dieter Gillesen ◽  
...  
Keyword(s):  
Human Liver ◽  
Lactic Dehydrogenase ◽  
Inhibitory Effects

scholarly journals In vitro inhibitory effects of cepharanthine on human liver cytochrome P450 enzymes

2020 ◽  
Vol 58 (1) ◽  
pp. 247-252
Author(s):  
Xunge Zhang ◽  
Ping Feng ◽  
Xinfu Gao ◽  
Bin Wang ◽  
Chunxia Gou ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Cytochrome P450 Enzymes ◽  
Inhibitory Effects ◽  
Liver Cytochrome

scholarly journals Erratum: In Vitro Metabolism and Inhibitory Effects of Pranlukast in Human Liver Microsomes [Biol. Pharm. Bull. 32(4): 688-693 (2009)]

2009 ◽  
Vol 32 (7) ◽  
pp. 1311
Author(s):  
Kazuhiro Yoneda ◽  
Ichiro Matsumoto ◽  
Fumitaka Sutoh ◽  
Ryunosuke Higashi ◽  
Ken-ichi Nunoya ◽  
...  
Keyword(s):  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
In Vitro Metabolism ◽  
Inhibitory Effects
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