Potential role of leptin in increase of fatty acid synthase gene expression in chicken liver

2005 ◽  
Vol 29 (4) ◽  
pp. 646-660 ◽  
Author(s):  
Sami Dridi ◽  
Johan Buyse ◽  
Eddy Decuypere ◽  
Mohammed Taouis
Keyword(s):  
Gene Expression ◽  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Potential Role ◽  
Chicken Liver ◽  
Fatty Acid Synthase Gene

scholarly journals Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Tamires Aparecida Bitencourt ◽  
Tatiana Takahasi Komoto ◽  
Bruna Gabriele Massaroto ◽  
Carlos Eduardo Saraiva Miranda ◽  
Rene Oliveira Beleboni ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Trichophyton Rubrum ◽  
Ergosterol Content ◽  
Fatty Acid Synthase Gene

Fatty acid synthase gene expression in rat mammary carcinoma

Lipids ◽  
1999 ◽  
Vol 34 (S1) ◽  
pp. S223-S223
Author(s):  
S. Cognault ◽  
E. Germain ◽  
P. Bougnoux ◽  
C. Lhuillery
Keyword(s):  
Gene Expression ◽  
Fatty Acid ◽  
Mammary Carcinoma ◽  
Fatty Acid Synthase ◽  
Fatty Acid Synthase Gene

Analysis of the Expression of Genes Related to Lipidic and Glycogenic Metabolism in Pleomorphic Adenomas and Carcinomas Ex Pleomorphic Adenomas

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S135-S136
Author(s):  
Erika Egal ◽  
Joao Scarini ◽  
Larissa Fernandes ◽  
Welligton Sabino ◽  
Reydson Souza ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acid ◽  
Pleomorphic Adenoma ◽  
Malignant Transformation ◽  
Fatty Acid Synthase ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Glut 1 ◽  
Significant Difference ◽  
Pleomorphic Adenomas

Abstract Introduction The carcinoma ex pleomorphic adenoma (CXPA) arises from a pleomorphic adenoma (PA) and is supposed to gain lipogenesis and glycogenesis during its malignant transformation. Increased lipogenesis is a characteristic of cancer cells, consisting of increased fatty acid synthesis by the enzyme fatty acid synthase (FASN) and by the accumulation of cytoplasmic lipid droplets, which express adipophilin. The increase in glycolytic metabolism has been associated with the activity of glycolytic enzymes and glucose transporters (GLUTs), whose expression is induced by HIF-1 (inducing factor of hypoxia 1). Objectives To analyze the gene expression of FASN, adipophilin, HIF-1α, and GLUT-1 in PA and CXPA samples. Methodology Gene expression analysis of the FASN, adipophilin, HIF1-α, and GLUT-1 genes was performed by the real-time PCR (qPCR) method. Fourteen cases of PA and 14 cases of CXAP were evaluated. Results FASN, adipophilin, HIF-1α, and GLUT-1 were more expressed in CXAP than in AP, although there was no significant difference between levels of adipophilin expression in CXPA and PA. Conclusion Increased expression of FASN, HIF1-α, and GLUT-1 in CXAP may be associated with malignant transformation of PA, while additional studies are needed to understand the role of adipophilin in PA carcinogenesis. Moreover, this is the first study to investigate the role of these genes in the malignant transformation of PA.

scholarly journals Induction of Fatty-Acid-Synthase Gene Expression by Glucose in Primary Culture of Rat Hepatocytes. Dependency upon Glucokinase Activity

1995 ◽  
Vol 230 (1) ◽  
pp. 309-315 ◽  
Author(s):  
Carina Prip-Buus ◽  
Dominique Perdereau ◽  
Fabienne Foufelle ◽  
Jocelyne Maury ◽  
Pascal Ferre ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acid ◽  
Primary Culture ◽  
Fatty Acid Synthase ◽  
Rat Hepatocytes ◽  
Fatty Acid Synthase Gene
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