Mutations in growth hormone gene affect stability of protein structure leading to reduced growth, reproduction, and milk production in crossbred cattle—an insight

2020 ◽  
Vol 71 ◽  
pp. 106405
Author(s):  
A. Pal ◽  
A. Pal ◽  
A.K. Chakravarty
Keyword(s):  
Growth Hormone ◽  
Protein Structure ◽  
Milk Production ◽  
Growth Hormone Gene ◽  
Crossbred Cattle

Growth Hormone Gene Polymorphism in Indigenous Cattle of North East India vis-a-vis Crossbred Cattle

2019 ◽  
pp. 1
Author(s):  
Keyolenu Yore ◽  
Chukham Gohain ◽  
Lalhruaitluangi Renthlei ◽  
Prava Mayengbam ◽  
Nongthombam Singh ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gene Polymorphism ◽  
Growth Hormone Gene ◽  
Crossbred Cattle ◽  
Indigenous Cattle ◽  
North East India ◽  
North East

Growth hormone gene variability and its effects on milk traits in primiparous Sarda goats

2013 ◽  
Vol 80 (3) ◽  
pp. 255-262 ◽  
Author(s):  
Maria Luisa Dettori ◽  
Angela Maria Rocchigiani ◽  
Sebastiano Luridiana ◽  
Maria Consuelo Mura ◽  
Vincenzo Carcangiu ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Milk Production ◽  
Milk Fat ◽  
Transcription Initiation ◽  
Growth Hormone Gene ◽  
Production Traits ◽  
Fat Percentage ◽  
Milk Traits ◽  
Exon 2 ◽  
Lactating Goats

The aim of this research was to investigate variability in each of the five exons of the caprine growth hormone (gGH) gene, in order to establish the possible relationships with milk traits in Sarda breed goat. The general linear model procedure was used to analyse the effects of the single strand conformation (SSCP) profiles on milk traits of 100 lactating goats. Analysis of conformational polymorphism at exons 1–5 revealed a total of 25 differing banding patterns. Sequencing revealed 21 nucleotide changes (compared with GenBank D00476): 14 were polymorphic and 7 monomorphic; 19 in exonic regions, 5 of which were nonsynonymous. A SNP upstream of the transcription initiation codon (c.-3A>G) and an indel (c.*29_30insC) in the 3′UTR, were detected. Alignment of 4 cloned sequences including the entire gGH gene led to the identification of 22 nucleotide variations within the intron regions, including two indels. Association analysis revealed that each exon, except exon-1, affected milk yield, exons 1 and 3 influenced milk fat percentage, and all exons, except exon-2, had an effect on protein percentage, supporting previous results in livestock. The variability detected at the caprine GH gene might provide useful information for the phylogeny of ruminants and, more importantly, have implications on the biological function of the growth hormone and on those traits resulting from its physiological action, including milk production and composition. The caprine GH gene may become a useful molecular marker for a more effective genetic selection for milk production traits in goats.

Taql growth hormone gene polymorphism and milk production traits in Holstein-Friesian cattle

1996 ◽  
Vol 63 (2) ◽  
pp. 175-181 ◽  
Author(s):  
M. Falaki ◽  
M. Sneyers ◽  
A. Prandi ◽  
S. Massart ◽  
C. Corradini ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Milk Production ◽  
Restriction Fragment ◽  
Milk Fat ◽  
Substitution Effect ◽  
Growth Hormone Gene ◽  
Production Traits ◽  
Milk Production Traits ◽  
Frequency Pattern ◽  
Holstein Friesian

AbstractThe positive effect of administration of growth hormone (GH) on milk production and its presence in selected dairy cattle lines of higher GH concentrations prompted an examination of the presence of restriction fragment length polymorphism (RFLP) in the growth hormone gene using the enzyme Taq/ and to investigate associations between this polymorphism and milk production traits. Blood was sampled from 251 Italian Holstein-Friesian cows. Three fragment bands, arbitrarily denoted A, B and E, of 6·2, 5·2 and 1·9 kilobase (kb), respectively, were observed. Their combinations exhibited six patterns, AA, AB, ABE, AE, BB and BE with frequencies of 64·5, 24·3, 2·4, 6·8, 1·4 and 0·4%, respectively. The statistical analysis was performed using linear mixed animal models. The results indicated an effect of the GHgene polymorphic Taq/restriction fragment on 305-day productions of milk, fat and protein; the low frequency pattern AE showed productions inferior to those for AA or AB patterns. Effect estimates of AA, AB and AE were, respectively, 200 (s.e. 215), 218 (s.e. 267) and -910 (s.e. 380) kg for milk production, 7·75 (s.e. 7·98), 16·10 (s.e. 9·79) and -22·14 (s.e. 14·42) kg for fat production, and 6·78 (s.e. 6·21), 8·57 (s.e. 7·58) and -20·74 (s.e. 11·14) kg for protein production. The average substitution effect estimates of E were -891 (s.e. 278), -26·56 (s.e. 10·16) and -24·50 (s.e. 9·43) kg for milk, fat and protein yields, respectively. In conclusion, these results suggest that the E fragment deserves further designed and specific study.

scholarly journals Associations between <i>Leu/Val</i> polymorphism of growth hormone gene and milk production traits in Black-and-White cattle

2002 ◽  
Vol 45 (5) ◽  
pp. 421-428 ◽  
Author(s):  
A. Dybus
Keyword(s):  
Growth Hormone ◽  
Milk Production ◽  
Milk Fat ◽  
Growth Hormone Gene ◽  
Production Traits ◽  
Milk Production Traits ◽  
Black And White ◽  
Holstein Friesian ◽  
Pcr Rflp ◽  
White Cattle

Abstract. Associations between polymorphism of the bovine growth hormone (GH) gene (Leu/Val) and milk production traits of Black-and-White cattle with different proportional share of Holstein Friesian genes were analysed. A total of 1086 cows were included in the study. PCR-RFLP method was used for genotyping. The frequencies of genotypes and alleles were as follows: 0.653 for LL genotype, 0.324 for LV and 0.023 for VV, and 0.815 for GHL and 0.185 for GHV. Associations between Leu/Val polymorphism and milk production traits of cows were found only in first lactation. Cows with LL genotype had higher milk, fat and protein yield compared to LV individuals (P ≤ 0.01).

scholarly journals The relation of GH1, GHR and DGAT1 polymorphisms with estimated breeding values for milk production traits of German Holstein sires

2008 ◽  
Vol 53 (No. 6) ◽  
pp. 238-246 ◽  
Author(s):  
E. Hradecká ◽  
J. Čítek ◽  
L. Panicke ◽  
V. Řehout ◽  
L. Hanusová
Keyword(s):  
Growth Hormone ◽  
Milk Production ◽  
Milk Fat ◽  
Milk Protein ◽  
Growth Hormone Gene ◽  
Production Traits ◽  
Milk Production Traits ◽  
Breeding Values ◽  
Fat Yield ◽  
Estimated Breeding Values

: We analysed the relations of estimated breeding values (EBV) of 315 German Holstein sires to their genotypes in growth hormone gene (<i>GH1</i>), growth hormone receptor gene (<i>GHR</i>) and acylCoA-diacylglycerol acyltransferase 1 (<i>DGAT1</i>). The strong relation of <i>DGAT1 K232A</i> to the estimated breeding values for milk production traits has been confirmed, when allele <i>DGAT1<sup>K</sup></i> was connected with higher milk fat yield, milk fat and milk protein content, while allele <i>DGAT1<sup>A</sup></i> increased milk yield and milk protein yield. The effect of <i>DGAT1</i> genotype explained from 4.70% of variability of EBVs for fat yield to 31.90% of variability of EBVs for fat content. The evaluation of <i>GH1</i> 127 Leu/Val and <i>GHR</i> 257 SNP polymorphisms did not reveal an association of their polymorphism with EBVs for milk production traits, except the EBVs of <i>GHR<sup>G</sup>/GHR<sup>G</sup></i> homozygotes for fat yield, which were significantly lower. The effect of <i>GH1</i> or <i>GHR genotype explained only a negligible portion of variability of EBVs (<i>R</i><sup>2</sup> < 1.00% in most cases).

scholarly journals Effect of Growth Hormone Gene Polymorphism on Milk Quality Traits in Crossbred Cattle

2003 ◽  
Vol 24 (2) ◽  
pp. 145-151
Author(s):  
T. K. Biswas ◽  
T. K. Bhattacharya ◽  
A. D. Narayan ◽  
S. Badola ◽  
Pushpendra Kumar ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gene Polymorphism ◽  
Milk Quality ◽  
Growth Hormone Gene ◽  
Quality Traits ◽  
Crossbred Cattle
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