The folate receptor as a rational therapeutic target for personalized cancer treatment

2014 ◽  
Vol 17 (4-6) ◽  
pp. 89-95 ◽  
Author(s):  
Yehuda G. Assaraf ◽  
Christopher P. Leamon ◽  
Joseph A. Reddy
Keyword(s):  
Cancer Treatment ◽  
Therapeutic Target ◽  
Folate Receptor ◽  
Personalized Cancer

Oncogenomics and CYP450 Implications in Personalized Cancer Therapy

2020 ◽  
Vol 17 (2) ◽  
pp. 104-113
Author(s):  
G.K. Udayaraja ◽  
I. Arnold Emerson
Keyword(s):  
Cytochrome P450 ◽  
Cancer Treatment ◽  
Cancer Susceptibility ◽  
Mutant Gene ◽  
Genome Project ◽  
Interdisciplinary Field ◽  
Precision Therapy ◽  
Personalized Cancer Therapy ◽  
Personalized Cancer ◽  
Genetic Events

Background: The Human Genome Project has unleashed the power of genomics in clinical practice as a choice of individualized therapy, particularly in cancer treatment. Pharmacogenomics is an interdisciplinary field of genomics that deals with drug response, based on individual genetic makeup. Objective: The main genetic events associated with carcinogenesis activate oncogenes or inactivate tumor-suppressor genes. Therefore, drugs should be specific to inactivate or regulate these mutant genes and their protein products for effective cancer treatment. In this review, we summarize how polymedication decisions in cancer treatments based on the evaluation of cytochrome P450 (CYP450) polymorphisms are applied for pharmacogenetic assessment of anticancer therapy outcomes. Results: However, multiple genetic events linked, inactivating a single mutant gene product, may be insufficient to inhibit tumor progress. Thus, genomics and pharmacogenetics directly influence a patient’s response and aid in guiding clinicians to select the safest and most effective combination of medications for a cancer patient from the initial prescription. Conclusion: This review outlines the roles of oncogenes, the importance of cytochrome P450 (CYP450) in cancer susceptibility, and its impact on drug metabolism, proposing combined approaches to achieve precision therapy.

scholarly journals Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report

2015 ◽  
Vol 6 (2) ◽  
pp. 139-143 ◽  
Author(s):  
Jonai Pujol-Gimenez ◽  
Fátima Pérez de Heredia ◽  
Miguel Angel Idoate ◽  
Rachel Airley ◽  
María Pilar Lostao ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Therapeutic Target ◽  
Preliminary Report ◽  
Potential Therapeutic Target

scholarly journals Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment

2018 ◽  
Vol 87 (6) ◽  
pp. 1474-1480 ◽  
Author(s):  
Herve Tiriac ◽  
Juan Carlos Bucobo ◽  
Demetrios Tzimas ◽  
Suman Grewel ◽  
Joseph F. Lacomb ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Treatment ◽  
Needle Biopsy ◽  
Fine Needle Biopsy ◽  
Fine Needle ◽  
Personalized Cancer

Estrogen signaling: An emanating therapeutic target for breast cancer treatment

2019 ◽  
Vol 177 ◽  
pp. 116-143 ◽  
Author(s):  
Tanmay Saha ◽  
Subhajit Makar ◽  
Rayala Swetha ◽  
Gopichand Gutti ◽  
Sushil K. Singh
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Therapeutic Target ◽  
Breast Cancer Treatment ◽  
Estrogen Signaling
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