Effect of melatonin in reducing second-generation antipsychotic metabolic effects: A double blind controlled clinical trial

2018 ◽  
Vol 12 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Mansour Agahi ◽  
Negar Akasheh ◽  
Afshin Ahmadvand ◽  
Hossein Akbari ◽  
Fatemeh Izadpanah
Keyword(s):  
Clinical Trial ◽  
Second Generation ◽  
Metabolic Effects ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Second Generation Antipsychotic

Melatonin attenuates antipsychotic metabolic effects: an eight-week randomized, double-blind, parallel-group, placebo-controlled clinical trial

2014 ◽  
Vol 16 (4) ◽  
pp. 410-421 ◽  
Author(s):  
Francisco Romo-Nava ◽  
Dení Alvarez-Icaza González ◽  
Ana Fresán-Orellana ◽  
Ricardo Saracco Alvarez ◽  
Claudia Becerra-Palars ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Metabolic Effects ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Parallel Group

Double blind placebo controlled clinical trial of homoeopathic medicines in HIV infection

1998 ◽  
Vol 87 (2) ◽  
pp. 86-88
Author(s):  
D P Rastogi ◽  
V P Singh ◽  
Vikram Singh ◽  
S K Dey ◽  
K Rao
Keyword(s):  
Clinical Trial ◽  
Hiv Infection ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Administration of Apple Polyphenol Supplements for Skin Conditions in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1071
Author(s):  
Toshihiko Shoji ◽  
Saeko Masumoto ◽  
Nina Moriichi ◽  
Yasuyuki Ohtake ◽  
Tomomasa Kanda
Keyword(s):  
Clinical Trial ◽  
Uv Irradiation ◽  
Skin Pigmentation ◽  
Controlled Clinical Trial ◽  
Continuous Administration ◽  
Double Blind ◽  
Healthy Women ◽  
Dependent Relationship ◽  
Skin Conditions ◽  
Double Blinded

This clinical study was performed to evaluate the effects of continuous apple polyphenol (AP) administration on facial skin conditions and pigmentation induced by ultraviolet (UV) irradiation in healthy women participants. Participants (n = 65, age 20–39 years) were randomized to receive tablets containing AP (300 or 600 mg/day) or placebo in a double-blinded, placebo-controlled clinical trial. Continuous administration of AP for 12 weeks significantly prevented UV irradiation induced skin pigmentation (erythema value, melanin value, L value), although a dose-dependent relationship was not clearly observed. In contrast, no significant differences were detected between the groups with regard to water content and trans-epidermal water loss. Our study demonstrated that APs and their major active compounds, procyanidins, have several health benefits. Here, we report that continuous administration of AP for 12 weeks alleviated UV irradiation induced skin pigmentation, when compared with placebo, in healthy women.

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