A targeted proteomics approach reveals a serum protein signature as diagnostic biomarker for resectable gastric cancer

Introduction. The effectiveness of the Asian regimen of adjuvant chemotherapy in patients with gastric cancer in the European population remains unclear. The aim of our study was a retrospective assessment of adjuvant chemotherapy (XELOX regimen) after radical surgery (R0) on overall survival. Methods. Database of pts with resectable gastric cancer with stage >pT3 and/or pN+ and M0, who were operated (R0) at single oncological institution during 2007-2017 was reviewed. In univariate and multivariate analyzes were included demographic characteristics, type of tumor according to Lauren, stage, type of treatment and others. Results. 396 pts were identified and 286 were available for analysis.106 (37%) pts received at least one cycle of adjuvant chemotherapy. In univariate analysis, 5OS rate was 64% [95% Cl, 52-80] и 56% [95% Cl, 48-64; p=0,21] in patients received adjuvant chemotherapy and only surgical treatment. After stratifying patients depending on the regional lymph nodes metastasis, 5OS rate in pts with pN1-3 was 69% [95% CI, 57-85] vs 47% [95% CI, 39-58; p = 0,01], respectively...

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Multimodal Treatments for Resectable Gastric Cancer: A Systematic Review and Network Meta-Analysis

SSRN Electronic Journal ◽

10.2139/ssrn.3255842 ◽

2018 ◽

Author(s):

Ji Cheng ◽

Ming Cai ◽

Xiaoming Shuai ◽

Jinbo Gao ◽

Guobin Wang ◽

...

Keyword(s):

Gastric Cancer ◽

Systematic Review ◽

Meta Analysis ◽

Resectable Gastric Cancer

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Mirtronic miR-4646-5p promotes gastric cancer metastasis by regulating ABHD16A and metabolite lysophosphatidylserines

Cell Death and Differentiation ◽

10.1038/s41418-021-00779-y ◽

2021 ◽

Author(s):

Liping Yang ◽

Yixuan Hou ◽

Yan-e Du ◽

Qiao Li ◽

Fanlin Zhou ◽

...

Keyword(s):

Gastric Cancer ◽

Lipid Metabolism ◽

Gastric Cancer Cell ◽

Cancer Metastasis ◽

Host Gene ◽

Diagnostic Biomarker ◽

Invasion And Metastasis ◽

Gastric Cancer Cells ◽

Tumor Progress ◽

Abnormal Lipid Metabolism

AbstractThe aberrant classical miRNAs are considered to play significant roles in tumor progression. However, it remains unclear for nonclassical miRNAs, a set of Drosha-independent miRNAs in the process of various biology. Here, we reveal that a nonclassical miR-4646-5p plays a pivotal role in gastric cancer (GC) metastasis. MiR-4646-5p, one of Drosha-independent mirtronic miRNA, is aberrant up-regulated in Drosha-low expressed GC and Drosha-knockdown gastric cancer cells. Mirtronic miR-4646-5p is a specific transcription splicing product of intron 3 of the host gene Abhd16a with the aid of SRSF2. The enhanced miR-4646-5p can stabilize HIF1A by targeting PHD3 to positive feedback regulate Abhd16a and miR-4646-5p itself expressions. ABHD16A, as an emerging phosphatidylserine-specific lipase, involves in lipid metabolism leading to lysophosphatidylserines (lyso-PSs) accumulation, which stimulates RhoA and downstream LIMK/cofilin cascade activity through GPR34/Gi subunit, thus causes metastasis of gastric cancer. In addition, miR-4646-5p/PHD3/HIF1A signaling can also up-regulate RhoA expression and synergistically promote gastric cancer cell invasion and metastasis. Our study provides new insights of nonclassical mirtronic miRNA on tumor progress and may serve as a new diagnostic biomarker for gastric cancer. MiR-4646-5p and its host gene Abhd16a mediated abnormal lipid metabolism may be a new target for clinical treatment of gastric cancer.

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