Paraquat increases Interleukin-1β in hippocampal dentate gyrus to impair hippocampal neurogenesis in adult mice

2020 ◽  
Vol 200 ◽  
pp. 110733
Author(s):  
Qian Li ◽  
Hongxi Xiao ◽  
Yiming Shao ◽  
Xiuli Chang ◽  
Yubin Zhang ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Hippocampal Neurogenesis ◽  
Interleukin 1Β ◽  
Hippocampal Dentate Gyrus ◽  
Adult Mice

scholarly journals Metabolic tuning of inhibition regulates hippocampal neurogenesis in the adult brain

2020 ◽  
Vol 117 (41) ◽  
pp. 25818-25829
Author(s):  
Xinxing Wang ◽  
Hanxiao Liu ◽  
Johannes Morstein ◽  
Alexander J. E. Novak ◽  
Dirk Trauner ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Energy Homeostasis ◽  
Inhibitory Neuron ◽  
Hippocampal Neurogenesis ◽  
Adult Brain ◽  
Adult Hippocampal Neurogenesis ◽  
Neuron Activity ◽  
Adult Mice ◽  
Sphingosine 1 Phosphate ◽  
Underlying Mechanisms

Hippocampus-engaged behaviors stimulate neurogenesis in the adult dentate gyrus by largely unknown means. To explore the underlying mechanisms, we used tetrode recording to analyze neuronal activity in the dentate gyrus of freely moving adult mice during hippocampus-engaged contextual exploration. We found that exploration induced an overall sustained increase in inhibitory neuron activity that was concomitant with decreased excitatory neuron activity. A mathematical model based on energy homeostasis in the dentate gyrus showed that enhanced inhibition and decreased excitation resulted in a similar increase in neurogenesis to that observed experimentally. To mechanistically investigate this sustained inhibitory regulation, we performed metabolomic and lipidomic profiling of the hippocampus during exploration. We found sustainably increased signaling of sphingosine-1-phosphate, a bioactive metabolite, during exploration. Furthermore, we found that sphingosine-1-phosphate signaling through its receptor 2 increased interneuron activity and thus mediated exploration-induced neurogenesis. Taken together, our findings point to a behavior-metabolism circuit pathway through which experience regulates adult hippocampal neurogenesis.

scholarly journals Interleukin-1β increases neuronal death in the hippocampal dentate gyrus associated with status epilepticus in the developing rat

2017 ◽  
Vol 32 (9) ◽  
pp. 587-594
Author(s):  
C. Rincón-López ◽  
A. Tlapa-Pale ◽  
J.-S. Medel-Matus ◽  
J. Martínez-Quiroz ◽  
J.F. Rodríguez-Landa ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Dentate Gyrus ◽  
Neuronal Death ◽  
Interleukin 1Β ◽  
Hippocampal Dentate Gyrus ◽  
Developing Rat

Regeneration of granule neurons after lesioning of hippocampal dentate gyrus: Evaluation using adult mice treated with trimethyltin chloride as a model

2005 ◽  
Vol 82 (5) ◽  
pp. 609-621 ◽  
Author(s):  
Kiyokazu Ogita ◽  
Norito Nishiyama ◽  
Chie Sugiyama ◽  
Kei Higuchi ◽  
Masanori Yoneyama ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Granule Neurons ◽  
Hippocampal Dentate Gyrus ◽  
Adult Mice ◽  
Trimethyltin Chloride

Malfunctional Reorganization in the Developing Limbo-Prefrontal System in Animals: Implications for Human Psychoses?

2001 ◽  
Vol 12 (1) ◽  
pp. 8-14
Author(s):  
Gertraud Teuchert-Noodt ◽  
Ralf R. Dawirs
Keyword(s):  
Prefrontal Cortex ◽  
Mental Disorders ◽  
Dentate Gyrus ◽  
Cognitive Functions ◽  
Experimental Approach ◽  
Regulatory Mechanisms ◽  
Hippocampal Dentate Gyrus ◽  
Non Invasive ◽  
Invasive Method ◽  
Activity Dependent

Abstract: Neuroplasticity research in connection with mental disorders has recently bridged the gap between basic neurobiology and applied neuropsychology. A non-invasive method in the gerbil (Meriones unguiculus) - the restricted versus enriched breading and the systemically applied single methamphetamine dose - offers an experimental approach to investigate psychoses. Acts of intervening affirm an activity dependent malfunctional reorganization in the prefrontal cortex and in the hippocampal dentate gyrus and reveal the dopamine position as being critical for the disruption of interactions between the areas concerned. From the extent of plasticity effects the probability and risk of psycho-cognitive development may be derived. Advance may be expected from insights into regulatory mechanisms of neurogenesis in the hippocampal dentate gyrus which is obviously to meet the necessary requirements to promote psycho-cognitive functions/malfunctions via the limbo-prefrontal circuit.

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