The effects of lycopene on the proliferation of human breast cells and BRCA1 and BRCA2 gene expression

2004 ◽  
Vol 40 (11) ◽  
pp. 1768-1775 ◽  
Author(s):  
N Chalabi ◽  
L Le Corre ◽  
J-C Maurizis ◽  
Y-J Bignon ◽  
D.J Bernard-Gallon
Keyword(s):  
Gene Expression ◽  
Brca2 Gene ◽  
Human Breast ◽  
Brca1 And Brca2 ◽  
Breast Cells

scholarly journals Comparative activity of pulsed or continuous estradiol exposure on gene expression and proliferation of normal and tumoral human breast cells

2002 ◽  
Vol 28 (3) ◽  
pp. 165-175 ◽  
Author(s):  
V Cavailles ◽  
A Gompel ◽  
MC Portois ◽  
S Thenot ◽  
N Mabon ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Lines ◽  
Hormone Replacement ◽  
Primary Cultures ◽  
Continuous Treatment ◽  
Luciferase Reporter ◽  
Breast Cancer Cell Lines ◽  
Human Breast ◽  
Kinetic Profile ◽  
Breast Cells

Intranasal administration of hormone replacement therapy presents an original plasma kinetic profile with transient estrogen levels giving rise to the concept of pulsed therapy. To further understand the molecular effects of this new therapy, we have compared the effects of pulsed and continuous estradiol treatments on two critical aspects of estradiol action: gene expression and cell proliferation. Cells were stimulated with estradiol as 1-h pulsed or 24-h continuous treatments at concentrations such that the 24-h exposure (concentration x time) was identical in both conditions. In MCF7 cells, the transcriptional activity of estrogen receptors (ER) on a transiently transfected responsive estrogen response element-luciferase reporter construct was shown to be drastically (approximately 10-fold) and similarly stimulated after both treatments. Moreover, the increased mRNA expression of three representative estradiol-sensitive genes (pS2, cathepsin D, progesterone receptor), evaluated by Northern blot, was identical after 1-h pulse with 7 nM estradiol or continuous treatment with 0.29 nM estradiol with the same kinetic profile over 48 h. Proliferation was quantified by a histomorphometric method on primary cultures of human normal breast cells from reduction mammoplasties and using a fluorescence DNA assay in six human breast cancer cell lines which were ER positive or negative. After a 7-day treatment period, estradiol had no effect on the proliferation of the three ER negative cell lines (BT20, MDA MB231, SK BR3) but significantly stimulated the proliferation of the normal cells and of the three tumoral hormone-sensitive cell lines (MCF7, T47D, ZR 75-1); both hormone treatments producing the same increases in cell growth. In conclusion, we have shown that the genomic or proliferative effects of estradiol were identical with pulsed or continuous treatments, thus indicating that estrogenic effects are not strictly related to concentrations but rather to total hormone exposure.

scholarly journals Allelic imbalance in BRCA1 and BRCA2 gene expression is associated with an increased breast cancer risk

2008 ◽  
Vol 17 (9) ◽  
pp. 1336-1348 ◽  
Author(s):  
Xiaowei Chen ◽  
JoEllen Weaver ◽  
Betsy A. Bove ◽  
Lisa A. Vanderveer ◽  
Susan C. Weil ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Allelic Imbalance ◽  
Brca2 Gene ◽  
Brca1 And Brca2

scholarly journals Alternative initiation and splicing in dicer gene expression in human breast cells

2005 ◽  
Vol 7 (4) ◽  
Author(s):  
Charletha V Irvin-Wilson ◽  
Gautam Chaudhuri
Keyword(s):  
Gene Expression ◽  
Human Breast ◽  
Breast Cells

scholarly journals Anti-Mullerian hormone (AMH) regulates BRCA1 and BRCA2 gene expression in an ovarian cortex transplantation model

2016 ◽  
Vol 106 (3) ◽  
pp. e120
Author(s):  
L. Detti ◽  
N.M. Fletcher ◽  
G.M. Saed ◽  
R.A. Uhlmann ◽  
M. Christiansen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Brca2 Gene ◽  
Brca1 And Brca2 ◽  
Ovarian Cortex ◽  
Transplantation Model

scholarly journals Identification of a GABPα/β Binding Site Involved in the Induction of Oxytocin Receptor Gene Expression in Human Breast Cells. Potentiation by c-Fos/c-Jun*

Endocrinology ◽  
1999 ◽  
Vol 140 (5) ◽  
pp. 2268-2279 ◽  
Author(s):  
Sarasija Hoare ◽  
John A. Copland ◽  
Thomas G. Wood ◽  
Yow-Jiun Jeng ◽  
Michael G. Izban ◽  
...  
Keyword(s):  
Gene Expression ◽  
Binding Site ◽  
Receptor Gene ◽  
Oxytocin Receptor ◽  
Human Breast ◽  
Oxytocin Receptor Gene ◽  
Breast Cells ◽  
Receptor Gene Expression

Allelic Imbalance in BRCA1 and BRCA2 Gene Expression and Familial Ovarian Cancer

2010 ◽  
Vol 20 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Jie Shen ◽  
Leo Medico ◽  
Hua Zhao
Keyword(s):  
Gene Expression ◽  
Ovarian Cancer ◽  
Allelic Imbalance ◽  
Brca2 Gene ◽  
Brca1 And Brca2 ◽  
Familial Ovarian Cancer

Anti-Müllerian Hormone (AMH) regulates BRCA1 and BRCA2 gene expression after ovarian cortex transplantation

2020 ◽  
pp. 1-4
Author(s):  
Irene Peregrin-Alvarez ◽  
Nicole M. Fletcher ◽  
Ghassan M. Saed ◽  
Robert A. Roman ◽  
Laura Detti
Keyword(s):  
Gene Expression ◽  
Brca2 Gene ◽  
Brca1 And Brca2 ◽  
Ovarian Cortex

Gene-expression profiling of breast cells purified with laser microdissection: identification of genes associated with tumor development

2005 ◽  
Vol 127 (04) ◽  
Author(s):  
U Kringel ◽  
C Ostwald ◽  
D Koczan ◽  
H Terpe ◽  
B Gerber ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Laser Microdissection ◽  
Tumor Development ◽  
Breast Cells
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