Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer

Abstract Purpose To gain more insight into the course of chemotherapy-induced peripheral neuropathy (CIPN) and its impact on health-related quality of life (HRQoL) in a population-based sample of colorectal cancer (CRC) patients up to 2 years after diagnosis. Methods All newly diagnosed CRC patients from four hospitals in the Netherlands were eligible for participation in an ongoing prospective cohort study. Patients (n = 340) completed questions on CIPN (EORTC QLQ-CIPN20) and HRQoL (EORTC QLQ-C30) before initial treatment (baseline) and 1 and 2 years after diagnosis. Results Among chemotherapy-treated patients (n = 105), a high sensory peripheral neuropathy (SPN) level was reported by 57% of patients at 1 year, and 47% at 2-year follow-up, whereas a high motor peripheral neuropathy (MPN) level was reported by 47% and 28%, at years 1 and 2, respectively. Linear mixed model analyses showed that SPN and MPN symptoms significantly increased from baseline to 1-year follow-up and did not return to baseline level after 2 years. Patients with a high SPN or MPN level reported a worse global quality of life and a worse physical, role, emotional, cognitive, and social functioning compared with those with a low SPN or MPN level. Conclusions Future studies should focus on understanding the mechanisms underlying CIPN so targeted interventions can be developed to reduce the impact of CIPN on patient’s lives. Implications for cancer survivors Patients need to be informed of both CIPN and the impact on HRQoL.

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Measuring health-related quality of life in colorectal cancer patients: systematic review of measurement properties of the EORTC QLQ-CR29

Supportive Care in Cancer ◽

10.1007/s00520-019-04764-7 ◽

2019 ◽

Vol 27 (7) ◽

pp. 2395-2412

Author(s):

Anja van der Hout ◽

Koen I. Neijenhuijs ◽

Femke Jansen ◽

Cornelia F. van Uden-Kraan ◽

Neil K. Aaronson ◽

...

Keyword(s):

Quality Of Life ◽

Colorectal Cancer ◽

Systematic Review ◽

Measurement Properties ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Eortc Qlq ◽

Colorectal Cancer Patients

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Validation of the Danish version of the disease specific instrument EORTC QLQ-CR38 to assess Health-related quality of life in patients with colorectal cancer

Health and Quality of Life Outcomes ◽

10.1186/1477-7525-10-150 ◽

2012 ◽

Vol 10 (1) ◽

pp. 150 ◽

Cited By ~ 13

Author(s):

Henriette Thaysen ◽

P Jess ◽

Søren Laurberg ◽

M Groenvold

Keyword(s):

Quality Of Life ◽

Colorectal Cancer ◽

Health Related Quality ◽

Specific Instrument ◽

Danish Version ◽

Related Quality ◽

Health Related ◽

Eortc Qlq ◽

Disease Specific

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Health-related quality of life in Slovenian patients with colorectal cancer: a single tertiary care center study

Radiology and Oncology ◽

10.2478/raon-2019-0015 ◽

2019 ◽

Vol 53 (2) ◽

pp. 231-237 ◽

Cited By ~ 2

Author(s):

Jan Grosek ◽

Jerica Novak ◽

Katja Kitek ◽

Alta Bajric ◽

Ana Majdic ◽

...

Keyword(s):

Quality Of Life ◽

Colorectal Cancer ◽

Care Center ◽

Tertiary Care ◽

Health Related Quality ◽

Slovenian Population ◽

Related Quality ◽

Health Related ◽

Eortc Qlq

Abstract Background The aim of this study was to evaluate the influence of the surgical treatment on Slovenian colorectal cancer patients’ health-related quality of life and to compare the results to the health-related quality of life of the general Slovenian population. Patients and methods A total of 413 patients with colorectal cancer operated on at the Abdominal Surgery Department at the Ljubljana University Medical Center between January 1st, 2016 and December 31st, 2017 were sent two standardized and validated questionnaires: the EORTC QLQ-C30 version 3 and EORTC QLQ-CR29. The questionnaires were returned by 197 patients. Results Compared to the general population, poorer physical (p < 0.001), role (p = 0.002), cognitive (p = 0.021), and social functioning (p < 0.001) with higher frequency of constipation (p < 0.001), diarrhea (p < 0.001), and financial difficulties (p < 0.001) were reported by the colorectal patients. Female patients reported lower cognitive (p = 0.034) and emotional (p = 0.008) functioning, as well as higher frequency of bloating (p = 0.049) and hair loss (p = 0.01). Compared to the younger group of patients, lower physical functioning (p < 0.001) and higher urinary frequency (p = 0.007), urinary incontinence (p = 0.007), buttock pain (p = 0.007), and anxiety regarding body weight (p = 0.031) were detected among the older group of colorectal patients. Conclusions The global health status of colorectal patients in Slovenia is comparable to that of the general Slovenian population, but there is a significantly lower level in some of the quality-of-life scales.

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Clinical and psychometric validation of a questionnaire module, the EORTC QLQ-OG25, to assess health-related quality of life in patients with cancer of the oesophagus, the oesophago–gastric junction and the stomach

European Journal of Cancer ◽

10.1016/j.ejca.2007.07.005 ◽

2007 ◽

Vol 43 (14) ◽

pp. 2066-2073 ◽

Cited By ~ 76

Author(s):

Pernilla Lagergren ◽

Peter Fayers ◽

Thierry Conroy ◽

Hubert J. Stein ◽

Orhan Sezer ◽

...

Keyword(s):

Quality Of Life ◽

Psychometric Validation ◽

Health Related Quality ◽

Patients With Cancer ◽

Related Quality ◽

Health Related ◽

Eortc Qlq

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Features and methods of assessing health-related quality of life and cognitive functions in patients with glial tumors

Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery) ◽

10.33920/med-01-2002-06 ◽

2020 ◽

pp. 47-56

Author(s):

Vera Arsenyeva ◽

Boris Martynov ◽

Gennadiy Bulyshchenko ◽

Dmitriy Svistov ◽

Boris Gaydar ◽

...

Keyword(s):

Quality Of Life ◽

Cognitive Functions ◽

Well Being ◽

Health Related Quality ◽

Number Of Patients ◽

Related Quality ◽

Health Related ◽

Eortc Qlq ◽

Patients With Epilepsy

Gliomas make up about 8 cases per 100,000 population and the number of patients with this disease is only increasing. There can be not only various types of neurological deficits among the symptoms, but also personal and emotional changes, that seriously affects the quality of life. The modern model of health care includes not only recovery of the patient’s physical functions, but also his or her psychosocial well-being. In particular, the assessment and study of the characteristics of health-related quality of life, as well as cognitive functions in patients with gliomas, is increasingly recognized as an important criterion when considering the effectiveness of treatment. To date, the features of health related quality of life and cognitive functions of patients with epilepsy and acute cerebral circulation disorders have been studied sufficiently, and, as a result, techniques have been developed that accurately assess the QOL and CF in patients with these diseases. These are QOLIE-31 and QOLIE-AD-48 questionnaires for patients with epilepsy. This is the National Institutes of Health Stroke Scale (NIHSS), Orgogozo stroke scale (OSS), World Federation of Neurological Surgeons (WFNS) scale for the clinical assessment of subarachnoid hemorrhage (SAH) for patients with acute cerebrovascular accident. At the same time, there are no generally accepted methods for assessing quality of life and neurocognitive functions that are sensitive to changes in the condition of patients with gliomas in the early postoperative period by the time of discharge from the hospital. As a result, there is no systematic information on the dynamics of the quality of life of such patients, their neurocognitive functioning. The purpose of this article was to study the literature on QOL and CF in patients affected by neurological and neurosurgical disorders for the further selection of optimal methods for assessing dynamics of the condition of patients with glial brain tumors before and after surgery. At the moment, such requirements are only partially met by the EORTC QLQ-C30 questionnaire and its application EORTC QLQ-BN20.

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Exploring the relationship among dispositional optimism, health-related quality of life, and CIPN severity among colorectal cancer patients with chronic peripheral neuropathy

Supportive Care in Cancer ◽

10.1007/s00520-021-06352-0 ◽

2021 ◽

Author(s):

Hester.R. Trompetter ◽

Cynthia S. Bonhof ◽

Lonneke V. van de Poll-Franse ◽

Gerard Vreugdenhil ◽

Floortje Mols

Keyword(s):

Quality Of Life ◽

Colorectal Cancer ◽

Peripheral Neuropathy ◽

Cancer Patients ◽

Anxiety Symptoms ◽

Health Related Quality ◽

Related Quality ◽

Health Related

Abstract Purpose Chemotherapy-induced peripheral neuropathy ((CI)PN) becomes chronic in 30% of cancer patients. Knowledge of predictors of chronic (CI)PN and related impairments in health-related quality of life (HRQoL) is lacking. We examined the role of optimism in chronic (CI)PN severity and associated HRQoL in colorectal cancer (CRC) patients up to two years after diagnosis. Methods CRC patients from a prospective cohort study participated, with sensory peripheral neuropathy (SPN) 1 year after diagnosis (n = 142). Multivariable regression analyses examined the cross-sectional association between optimism (measured by the LOT-R) and SPN severity/HRQoL (measured by the EORTC QLQ-CIPN20 and QLQ-C30), as well as the prospective association in a subsample that completed measures 2 years after diagnosis and still experienced SPN (n = 86). Results At 1-year follow-up, higher optimism was associated with better global HRQoL, and better physical, role, emotional, cognitive, and social functioning (all p < .01). Optimism at year one was also prospectively associated with better global HRQoL (p < .05), and emotional and cognitive functioning at 2-year follow-up (both p < .01). Optimism was not related to self-reported SPN severity. Significant associations were retained when controlling for demographic/clinical variables, and became non-significant after controlling for depressive and anxiety symptoms. Conclusions Optimism and depressive and anxiety symptoms are associated with HRQoL in CRC patients with chronic (CI)PN. Future research may illuminate the mechanisms that these factors share, like the use of (non)adaptive coping styles such as avoidance and acceptance that may inform the design of targeted interventions to help patients to adapt to chronic (CI)PN.

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